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IFN-α

Interferon alfa (IFN-α), popsaný roku 1957 jako protein schopný inhibice replikace viru chřipky, se řadí mezi interferony I. typu (IFN-I). Hlavním zdrojem IFN-α jsou především plazmacytoidní dendritické buňky a antigen prezentující buňky. U lidí bylo identifikováno 13 subtypů IFN-α, zatímco u myší 14. Geny pro IFN-α postrádají introny a leží v klastru na…

Funkce, Signalizace & Klinické využití

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Overview

Signalizace

Funkce

Klinické využití

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Map overview Semantic statistics

IFN-α

Nodes57
Edges56
Triples77
Avg. degree1.96
Density0.035088
Components1

How this topic connects Entity context

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IFN-α

Top relations

related to Kanonická signalizace · 17
IFN-α → Heterodimer STAT1/STAT2, Homodimer STAT1, IFNAR1, IFNAR2, IRF9, ISG, ISGF3, ISRE, JAK1, Janus, Následně, STAT1, STAT1/STAT2, STAT2, Tato, TYK2, Vazba IFN-α
related to Vliv na dendritické buňky (DC) · 15
IFN-α → CC-chemokine, CCR5, CCR7, CD40, CD80, CD83, CD86zvyšuje, CXC-chemokine, CXCL10, CXCL9, DC, GM-CSF, LFA1, MHC-I, MHC-II
related to Vliv na T buňky · 11
IFN-α → CD28, CD8, ICOSL, IFN-α2, IL-2, Interferencí, MAPK, PI3K, Také, TH1, TReg
related to Onkologie · 10
IFN-α → Drug Administration, FDA, Historickým, HIV, Hodkinův, Jednalo, Kaposiho, Poté, Protože, The Food
related to Virové infekce · 7
IFN-α → FDA, HCV, IFN, Kromě, Léčba, PIFN-α, Proto
related to Nekanonická signalizace · 6
IFN-α → GEF, ISG, MAPK, Pokud, Při, STAT
related to Vliv na produkci cytokinů · 6
IFN-α → IL-12, IL-15, IL-7, NK, Oproti, Signalizační
related to Vliv na přirozeně cytotoxické (NK) buňky · 5
IFN-α → IFN-γ, NCR1, NK, STAT1, Zároveň

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Important terminology

buněk buňky stat1 to afinitou nk receptor myší váže produkci dc dochází podporuje jako jsou ifnar1 ifnar2 lidí zatímco subtypy

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
IFN-αrelated to Kanonická signalizaceIFNAR10.60section
IFN-αrelated to Kanonická signalizaceIFNAR20.60section
IFN-αrelated to Kanonická signalizaceTYK20.60section
IFN-αrelated to Kanonická signalizaceJAK10.60section
IFN-αrelated to Kanonická signalizaceJanus0.60section
IFN-αrelated to Kanonická signalizaceVazba IFN-α0.60section
IFN-αrelated to Kanonická signalizaceNásledně0.60section
IFN-αrelated to Kanonická signalizaceSTAT10.60section
IFN-αrelated to Kanonická signalizaceSTAT20.60section
IFN-αrelated to Kanonická signalizaceTato0.60section
IFN-αrelated to Kanonická signalizaceSTAT1/STAT20.60section
IFN-αrelated to Kanonická signalizaceHeterodimer STAT1/STAT20.60section

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