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Ziconotide

Ziconotide, sold under the brand name Prialt, also called intrathecal ziconotide (ITZ) because of its administration route, is an atypical analgesic agent for the amelioration of severe and chronic pain. Derived from Conus magus, a cone snail, it is the synthetic form of an ω-conotoxin peptide.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N02BG08 (WHO)
Bioavailability
50%
CAS Number
107452-89-1 Y
ChEMBL
ChEMBL1201418 N

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Medical uses

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Mechanism of action

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Discovery

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Map overview Semantic statistics

Ziconotide

Nodes71
Edges70
Triples71
Avg. degree1.97
Density0.028169
Components1

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Ziconotide

Top relations

related to Discovery · 18
Ziconotide → Azur Pharma, Baldomero Olivera, Conus, December, Drug Administration, Elan Corporation, Europe, European Commission, February, Food, It, Michael McIntosh, Olivera, Philippines, Prialt, Scientists, University, Utah
related to External links · 7
Ziconotide → Chronic Severe Pain, Clinical, ClinicalTrials, NCT00076544, Patients, Safety Trial, Ziconotide Effectiveness
related to Medical uses · 7
Ziconotide → As, Due, FDA, However, IT, Research, US
has effect · 5
Ziconotide → Other, Others, Recent, The, Therefore
related to Structure · 5
Ziconotide → CKGKGAKCSRLMYDCCTGSCRSGKC-NH2, Cys1-Cys16, Cys15-Cys25, Cys8-Cys20, H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2
Legal status · 3
Ziconotide → EU: Rx-only, In general: ℞ (Prescription only), US: ℞-only
related to Mechanism of action · 3
Ziconotide → CGRP, N-type, This
3D model (JSmol) · 1
Ziconotide → Interactive image
AHFS/Drugs.com · 1
Ziconotide → Monograph
ATC code · 1
Ziconotide → N02BG08 (WHO)

Important terminology Word statistics

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Important terminology

intrathecal effects administration pain prialt severe drug peptide us side patients chronic snail approved treatment olivera name also derived conus

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Ziconotide3D model (JSmol)Interactive image1.00infobox
ZiconotideAHFS/Drugs.comMonograph1.00infobox
ZiconotideATC codeN02BG08 (WHO)1.00infobox
ZiconotideBioavailability50%1.00infobox
ZiconotideCAS Number107452-89-1 Y1.00infobox
ZiconotideChEMBLChEMBL1201418 N1.00infobox
ZiconotideChemSpider17291932 N1.00infobox
ZiconotideCompTox Dashboard (EPA)DTXSID608831741.00infobox
ZiconotideDrugBankDB06283 N1.00infobox
ZiconotideECHA InfoCard100.212.1741.00infobox
ZiconotideElimination half-life2.9–6.5 hours1.00infobox
ZiconotideExcretion<1% urine1.00infobox
ZiconotideFormulaC102H172N36O32S71.00infobox
ZiconotideIUPHAR/BPS25361.00infobox
ZiconotideKEGGD06363 Y1.00infobox
ZiconotideLegal statusUS: ℞-only1.00infobox
ZiconotideLegal statusEU: Rx-only1.00infobox
ZiconotideLegal statusIn general: ℞ (Prescription only)1.00infobox
ZiconotideLicense dataUS DailyMed: Ziconotide1.00infobox
ZiconotideMolar mass2639.14 g·mol−11.00infobox
ZiconotideOther namesSNX–1111.00infobox
ZiconotidePronunciation/zaɪˈkɒnoʊtaɪd/ zy-KON-oh-tyd1.00infobox
ZiconotidePubChem CID161354151.00infobox
ZiconotideRoutes of administrationIntrathecal1.00infobox
ZiconotideTrade namesPrialt1.00infobox
ZiconotideUNII7I64C51O161.00infobox

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