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Ziconotide: Applications, Adverse effects & Structure

Ziconotide, sold under the brand name Prialt, also called intrathecal ziconotide (ITZ) because of its administration route, is an atypical analgesic agent for the amelioration of severe and chronic pain. Derived from Conus magus, a cone snail, it is the synthetic form of an ω-conotoxin peptide.

Language: English [EN]
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Ziconotide topic overview

The analysis highlights Applications, Adverse effects and Structure as prominent areas in the source structure around Ziconotide.

Related topics
64
Source areas
6
Connected nodes
70
Extracted relationships
71
Concept neighborhoods
18
Bridge connections
70

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Adverse effects · 21 topics
Structure · 13 topics
Overview · 11 topics
Mechanism of action · 9 topics
Medical uses · 6 topics
Discovery · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N02BG08 (WHO)
Bioavailability
50%
CAS Number
107452-89-1 Y
ChEMBL
ChEMBL1201418 N

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Mechanism of action

Structure

Discovery

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Ziconotide connects Entity context

The extracted context around Ziconotide shows recurring relationship patterns in the source. For example, Ziconotide → Azur Pharma, Baldomero Olivera, Conus, December, Drug Administration, Elan Corporation, Europe, European Commission, February, Food, It, Michael McIntosh, Olivera, Philippines, Prialt, Scientists, University, Utah Another extracted example is Ziconotide → Chronic Severe Pain, Clinical, ClinicalTrials, NCT00076544, Patients, Safety Trial, Ziconotide Effectiveness. Use these groups to spot repeated connection types before inspecting the individual relationships.

Ziconotide

Top relations

related to Discovery · 18
Ziconotide → Azur Pharma, Baldomero Olivera, Conus, December, Drug Administration, Elan Corporation, Europe, European Commission, February, Food, It, Michael McIntosh, Olivera, Philippines, Prialt, Scientists, University, Utah
related to External links · 7
Ziconotide → Chronic Severe Pain, Clinical, ClinicalTrials, NCT00076544, Patients, Safety Trial, Ziconotide Effectiveness
related to Medical uses · 7
Ziconotide → As, Due, FDA, However, IT, Research, US
has effect · 5
Ziconotide → Other, Others, Recent, The, Therefore
related to Structure · 5
Ziconotide → CKGKGAKCSRLMYDCCTGSCRSGKC-NH2, Cys1-Cys16, Cys15-Cys25, Cys8-Cys20, H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2
Legal status · 3
Ziconotide → EU: Rx-only, In general: ℞ (Prescription only), US: ℞-only
related to Mechanism of action · 3
Ziconotide → CGRP, N-type, This
3D model (JSmol) · 1
Ziconotide → Interactive image
AHFS/Drugs.com · 1
Ziconotide → Monograph
ATC code · 1
Ziconotide → N02BG08 (WHO)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

intrathecal effects administration pain prialt severe drug peptide us side patients chronic snail approved treatment olivera name also derived conus

Ziconotide relationships Subject–Predicate–Object triples

TTTA extracted 71 structured relationships around Ziconotide. Examples in this analysis include Ziconotide → 3D model (JSmol) → Interactive image and Ziconotide → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Ziconotide3D model (JSmol)Interactive image1.00infobox
ZiconotideAHFS/Drugs.comMonograph1.00infobox
ZiconotideATC codeN02BG08 (WHO)1.00infobox
ZiconotideBioavailability50%1.00infobox
ZiconotideCAS Number107452-89-1 Y1.00infobox
ZiconotideChEMBLChEMBL1201418 N1.00infobox
ZiconotideChemSpider17291932 N1.00infobox
ZiconotideCompTox Dashboard (EPA)DTXSID608831741.00infobox
ZiconotideDrugBankDB06283 N1.00infobox
ZiconotideECHA InfoCard100.212.1741.00infobox
ZiconotideElimination half-life2.9–6.5 hours1.00infobox
ZiconotideExcretion<1% urine1.00infobox
ZiconotideFormulaC102H172N36O32S71.00infobox
ZiconotideIUPHAR/BPS25361.00infobox
ZiconotideKEGGD06363 Y1.00infobox
ZiconotideLegal statusUS: ℞-only1.00infobox
ZiconotideLegal statusEU: Rx-only1.00infobox
ZiconotideLegal statusIn general: ℞ (Prescription only)1.00infobox
ZiconotideLicense dataUS DailyMed: Ziconotide1.00infobox
ZiconotideMolar mass2639.14 g·mol−11.00infobox
ZiconotideOther namesSNX–1111.00infobox
ZiconotidePronunciation/zaɪˈkɒnoʊtaɪd/ zy-KON-oh-tyd1.00infobox
ZiconotidePubChem CID161354151.00infobox
ZiconotideRoutes of administrationIntrathecal1.00infobox
ZiconotideTrade namesPrialt1.00infobox
ZiconotideUNII7I64C51O161.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Ziconotide bring nearby vocabulary together. In this analysis, examples include Intrathecal, Patients and Severe. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Ziconotide
    • Intrathecal
    • Patients
    • Severe
    • Chronic
    • Drug
    • Prialt
    • Pain
    • Also
    • Citation
    • Due
    • Fda
    • Needed
  • ziconotide
    • Intrathecal
    • Patients
    • Severe
    • Chronic
    • Drug
    • Prialt
    • Pain
    • Also
    • Citation
    • Due
    • Fda
    • Needed
  • intrathecal
    • Fda
    • Us
    • Administration
    • Approved
    • Chronic
    • Treatment
    • Drug
    • Patients
    • Prialt
    • Severe
    • Ziconotide
    • Pain
  • food and drug administration
    • December
    • Food
    • Delivered
    • Drug
    • Fda
    • Fluid
    • Routes
    • Us
    • Intrathecal
    • Prialt
    • Analgesic
    • Due
  • mechanism of action
    • Delivered
    • Fluid
    • Routes
    • Citation
    • Common
    • December
    • Due
    • Fda
    • Food
    • Lack
    • Needed
    • Number
  • adverse effects
    • Side
    • Due
    • Olivera
    • Fluid
    • Routes
    • Fda
    • Food
    • Lack
    • Nausea
    • Needed
    • Number
    • Psychosis
  • chronic pain
    • Severe
    • Pain
    • Intrathecal
    • Patients
    • Prialt
    • Treatment
    • Citation
    • Fda
    • Name
    • Needed
    • Number
    • Us
  • when delivered
    • Fluid
    • Routes
    • Due
    • Fda
    • Food
    • Lack
    • Needed
    • Number
    • Us
    • Drug
    • Intrathecal
    • Prialt

Connections between topic areas Semantic bridges

For Ziconotide, one of the stronger structural bridges in this analysis connects Ziconotide with Adverse effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Ziconotide — Adverse effects · splits 49 ⟂ 22
Ziconotide — Structure · splits 57 ⟂ 14
Ziconotide — Overview · splits 59 ⟂ 12
Ziconotide — Mechanism of action · splits 61 ⟂ 10
Ziconotide — Medical uses · splits 64 ⟂ 7
Ziconotide — Discovery · splits 66 ⟂ 5

Map overview Semantic statistics

Ziconotide

Nodes71
Edges70
Triples71
Avg. degree1.97
Density0.028169
Components1

Source & methodology

TTTA analyzes the structure around Ziconotide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Adverse effects & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Ziconotide · EN edition · Analysis: TopicsToTalkAbout

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