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UNC-5 is a receptor for netrins including UNC-6. Netrins are a class of proteins involved in axon guidance. UNC-5 uses repulsion to direct axons while the other netrin receptor UNC-40 attracts axons to the source of netrin production.
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unc-6 axon cell guidance netrin netrin-1 axons receptor netrins spinal expression growth elegans migration ventral neurons signaling unc-129 dcc cord
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| UNC-5 | Membranome | 1137 | 1.00 | infobox |
| UNC-5 | Symbol | Netrin/DCC receptor | 1.00 | infobox |
| UNC-5 | is a | receptor for netrins including UNC-6 | 0.90 | text |
| antibody staining | instance of | Methods | 0.80 | text |
| transgene expression | instance of | Methods | 0.80 | text |
| microarray analysis have confirmed that UNC-5 is expressed in DA9 motor neurons | instance of | Methods | 0.80 | text |
| Wnt fibroblast growth factor can promote synapse formation | instance of | Extracellular cues | 0.80 | text |
| contradicting the traditional view of synapse formation from contact between synaptic partners to trigger the assembly of synaptic components | instance of | Extracellular cues | 0.80 | text |
| UNC-5 play essential roles in the formation | instance of | Inhibitory factors | 0.80 | text |
| maintenance of synaptic components.Adult expressionIn a study done in rat spinal cords | instance of | Inhibitory factors | 0.80 | text |
| increased netrin-1 | instance of | Inhibitory factors | 0.80 | text |
| UNC-5 homologue levels were observed compared to lower levels measured in the embryo | instance of | Inhibitory factors | 0.80 | text |
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