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Two-component regulatory system

In molecular biology, a two-component regulatory system serves as a basic stimulus-response coupling mechanism to allow organisms to sense and respond to changes in many different environmental conditions. Two-component systems typically consist of a membrane-bound histidine kinase that senses a specific environmental stimulus, and a corresponding…

Function, Histidine kinases & Mechanism

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Key facts & relationships

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AlphaFold
IPR016380 · PF06580
Available protein structures:
IPR016380 · PF06580
InterPro
IPR016380
OPM protein
5iji
OPM superfamily
281
PDB
IPR016380 PF06580 (ECOD; PDBsum)

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Overview

Mechanism

Function

Histidine kinases

Evolution

In eukaryotes

Bioinformatics

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Map overview Semantic statistics

Two-component regulatory system

Nodes100
Edges99
Triples10
Avg. degree1.98
Density0.02
Components1

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Two-component regulatory system

Top relations

AlphaFold · 2
Two-component regulatory system → IPR016380, PF06580
Available protein structures: · 2
Two-component regulatory system → IPR016380, PF06580
InterPro · 1
Two-component regulatory system → IPR016380
OPM protein · 1
Two-component regulatory system → 5iji
OPM superfamily · 1
Two-component regulatory system → 281
PDB · 1
Two-component regulatory system → IPR016380 PF06580 (ECOD; PDBsum)
Pfam · 1
Two-component regulatory system → PF06580
Symbol · 1
Two-component regulatory system → His_kinase

Important terminology Word statistics

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Important terminology

histidine two-component systems kinase response domain kinases genes regulator gene eukaryotes bacteria system typically phosphoryl membrane expression many signaling regulators

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Two-component regulatory systemAlphaFoldIPR0163801.00infobox
Two-component regulatory systemAlphaFoldPF065801.00infobox
Two-component regulatory systemAvailable protein structures:IPR0163801.00infobox
Two-component regulatory systemAvailable protein structures:PF065801.00infobox
Two-component regulatory systemInterProIPR0163801.00infobox
Two-component regulatory systemOPM protein5iji1.00infobox
Two-component regulatory systemOPM superfamily2811.00infobox
Two-component regulatory systemPDBIPR016380 PF06580 (ECOD; PDBsum)1.00infobox
Two-component regulatory systemPfamPF065801.00infobox
Two-component regulatory systemSymbolHis_kinase1.00infobox

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    Min side: 3
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