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TTC19: Structure, Clinical significance & Function

Tetratricopeptide repeat domain 19, also known as TPR repeat protein 19 or Tetratricopeptide repeat protein 19, mitochondrial is a protein that in humans is encoded by the TTC19 gene. This gene encodes a protein with a tetratricopeptide repeat (TPR) domain containing several TPRs of about 34 amino acids each. These repeats are found in a variety of…

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TTC19 topic overview

The analysis highlights Structure, Clinical significance and Function as prominent areas in the source structure around TTC19.

Related topics
46
Source areas
5
Connected nodes
51
Extracted relationships
119
Concept neighborhoods
21
Bridge connections
51

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 16 topics
Overview · 11 topics
Clinical significance · 10 topics
Function · 7 topics
Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TTC19, 2010204O13Rik, MC3DN2, tetratricopeptide repeat domain 19
Band
17p12 · 11|11 B2
Bgee
jejunal mucosa · mucosa of ileum · skin of thigh · cerebellar hemisphere · beta cell
BioGPS
n/a
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TTC19 connects Entity context

The extracted context around TTC19 shows recurring relationship patterns in the source. For example, TTC19 → beta cell, buccal mucosa cell, cerebellar hemisphere, dentate gyrus of hippocampal formation granule cell, duodenum, genital tubercle, jejunal mucosa, medial dorsal nucleus, mucosa of colon, mucosa of ileum, muscle of thigh, neural layer of retina, Paneth cell, primary visual cortex, right hemisphere of cerebellum, skin of thigh, superior frontal gyrus, temporal muscle, ventricular zone, visual cortex Another extracted example is TTC19 → Complex III, Cytochrome, Hinge, MTCYTB, Reductase, Rieske, Rieske Protein, Rieske-associated, The, The TTC19, Ubiquinol Cytochrome, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH. Use these groups to spot repeated connection types before inspecting the individual relationships.

TTC19

Top relations

Bgee · 20
TTC19 → beta cell, buccal mucosa cell, cerebellar hemisphere, dentate gyrus of hippocampal formation granule cell, duodenum, genital tubercle, jejunal mucosa, medial dorsal nucleus, mucosa of colon, mucosa of ileum, muscle of thigh, neural layer of retina, Paneth cell, primary visual cortex, right hemisphere of cerebellum, skin of thigh, superior frontal gyrus, temporal muscle, ventricular zone, visual cortex
RNA expression pattern · 20
TTC19 → beta cell, buccal mucosa cell, cerebellar hemisphere, dentate gyrus of hippocampal formation granule cell, duodenum, genital tubercle, jejunal mucosa, medial dorsal nucleus, mucosa of colon, mucosa of ileum, muscle of thigh, neural layer of retina, Paneth cell, primary visual cortex, right hemisphere of cerebellum, skin of thigh, superior frontal gyrus, temporal muscle, ventricular zone, visual cortex
related to Structure · 17
TTC19 → Complex III, Cytochrome, Hinge, MTCYTB, Reductase, Rieske, Rieske Protein, Rieske-associated, The, The TTC19, Ubiquinol Cytochrome, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH
Gene ontology · 12
TTC19 → cell cycle, cell division, centrosome, cytokinesis, membrane, midbody, mitochondrial inner membrane, mitochondrial respiratory chain complex III assembly, mitochondrion, mitotic cytokinesis, protein binding, respirasome
related to Clinical significance · 12
TTC19 → All Pathogenic, Clinical, III, In, MC3DN2, Mitochondrial, Q277, Q313X, Reductase, Such, Ubiquinol Cytochrome, Variants
related to Function · 10
TTC19 → ATP-coupled, Complex III, It, Reductase, Rieske, The TTC19, The Ubiquinol Cytochrome, Ubiquinol Cytochrome, UQCRFS1, UQCRFS1 N-terminal
related to Interactions · 7
TTC19 → Additional, CHMP4B, III, Rieske, UQCRC1, UQCRFS1, ZFYVE26
Band · 2
TTC19 → 11|11 B2, 17p12
Chr. · 2
TTC19 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
TTC19 → 16,045,015 bp, 62,219,277 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein mitochondrial iii complex bp chr human band cytochrome chromosome 17 respiratory chain uqcrfs1 domain ubiquinol reductase also tetratricopeptide

TTC19 relationships Subject–Predicate–Object triples

TTTA extracted 119 structured relationships around TTC19. Examples in this analysis include TTC19 → Aliases → TTC19, 2010204O13Rik, MC3DN2, tetratricopeptide repeat domain 19 and TTC19 → Band → 17p12. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TTC19AliasesTTC19, 2010204O13Rik, MC3DN2, tetratricopeptide repeat domain 191.00infobox
TTC19Band17p121.00infobox
TTC19Band11|11 B21.00infobox
TTC19Bgeejejunal mucosa1.00infobox
TTC19Bgeemucosa of ileum1.00infobox
TTC19Bgeeskin of thigh1.00infobox
TTC19Bgeecerebellar hemisphere1.00infobox
TTC19Bgeebeta cell1.00infobox
TTC19Bgeebuccal mucosa cell1.00infobox
TTC19Bgeeventricular zone1.00infobox
TTC19Bgeemucosa of colon1.00infobox
TTC19Bgeeright hemisphere of cerebellum1.00infobox
TTC19Bgeeduodenum1.00infobox
TTC19Bgeesuperior frontal gyrus1.00infobox
TTC19Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
TTC19Bgeemedial dorsal nucleus1.00infobox
TTC19Bgeevisual cortex1.00infobox
TTC19Bgeeprimary visual cortex1.00infobox
TTC19Bgeemuscle of thigh1.00infobox
TTC19BgeePaneth cell1.00infobox
TTC19Bgeetemporal muscle1.00infobox
TTC19Bgeegenital tubercle1.00infobox
TTC19Bgeeneural layer of retina1.00infobox
TTC19BioGPSn/a1.00infobox
TTC19Chr.Chromosome 17 (human)1.00infobox
TTC19Chr.Chromosome 11 (mouse)1.00infobox
TTC19DatabasesNCBI: entry; OMA: entry1.00infobox
TTC19End16,045,015 bp1.00infobox
TTC19End62,219,277 bp1.00infobox
TTC19EnsemblENSG000000112951.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TTC19 bring nearby vocabulary together. In this analysis, examples include Reductase, Ubiquinol and Cytochrome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • protein
    • Ttc19
    • Gene
    • Mitochondrial
    • Iii
    • Chain
    • Respiratory
    • Uqcrfs1
    • Cytokinesis
    • Tpr
    • Complex
    • Encoded
    • Inner
  • gene
    • Ttc19
    • Protein
    • Mitochondrial
    • Function
    • Location
    • Repeat
    • Tetratricopeptide
    • Complex
    • Iii
    • Chromosome
    • Human
    • Bp
  • inner mitochondrial membrane
    • Membrane
    • Complex
    • Iii
    • Chain
    • Respiratory
    • Ttc19
    • Nuclear
    • Protein
    • Gene
    • Encoded
    • Cytokinesis
    • Deficiency
  • complex iii
    • Complex
    • Iii
    • Mitochondrial
    • Respiratory
    • Nuclear
    • Ttc19
    • Deficiency
    • Protein
    • Gene
    • Cytochrome
    • Assembly
    • Encoded
  • mitochondrial respiratory chain
    • Respiratory
    • Complex
    • Iii
    • Nuclear
    • Chain
    • Mitochondrial
    • Ttc19
    • Assembly
    • Function
    • Inner
    • Membrane
    • Protein
  • rieske protein
    • Ttc19
    • Gene
    • Mitochondrial
    • Iii
    • Chain
    • Respiratory
    • Uqcrfs1
    • Cytokinesis
    • Tpr
    • Complex
    • Encoded
    • Inner
  • mitochondrial genome
    • Complex
    • Iii
    • Chain
    • Respiratory
    • Ttc19
    • Nuclear
    • Protein
    • Gene
    • Encoded
    • Deficiency
    • Cytochrome
    • Assembly
  • mitochondrial encephalopathy
    • Complex
    • Iii
    • Chain
    • Respiratory
    • Ttc19
    • Nuclear
    • Protein
    • Gene
    • Encoded
    • Deficiency
    • Cytochrome
    • Assembly

Connections between topic areas Semantic bridges

For TTC19, one of the stronger structural bridges in this analysis connects TTC19 with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TTC19Structure · splits 35 ⟂ 17
TTC19Overview · splits 40 ⟂ 12
TTC19Clinical significance · splits 41 ⟂ 11
TTC19Function · splits 44 ⟂ 8
TTC19Interactions · splits 49 ⟂ 3

Map overview Semantic statistics

TTC19

Nodes52
Edges51
Triples119
Avg. degree1.96
Density0.038462
Components1

Source & methodology

TTTA analyzes the structure around TTC19 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TTC19 · EN edition · Analysis: TopicsToTalkAbout

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