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CRTC1

CREB-regulated transcription coactivator 1 (CRTC1), previously referred to as TORC1 (Transducer Of Regulated CREB activity 1), is a protein that in humans is encoded by the CRTC1 gene. It is expressed in a limited number of tissues that include fetal brain and liver and adult heart, skeletal muscles, liver and salivary glands and various regions of the…

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Clinical significance

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Overview

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Aliases
CRTC1, MECT1, TORC-1, TORC1, WAMTP1, CREB regulated transcription coactivator 1, MAML2, Mam-2
Band
19p13.11 · 8|8 B3.3
Bgee
beta cell · paraflocculus of cerebellum · right hemisphere of cerebellum · Brodmann area 10 · middle frontal gyrus
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Clinical significance

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Map overview Semantic statistics

CRTC1

Nodes6
Edges5
Triples97
Avg. degree1.67
Density0.333333
Components1

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CRTC1

Top relations

Gene ontology · 27
CRTC1 → cAMP response element binding protein binding, cytoplasm, cytosol, dendrite, energy homeostasis, entrainment of circadian clock by photoperiod, glutamatergic synapse, memory, negative regulation of membrane hyperpolarization, nuclear body, nucleoplasm, nucleus, plasma membrane, positive regulation of CREB transcription factor activity, positive regulation of dendrite development, positive regulation of long-term synaptic potentiation, positive regulation of transcription by RNA polymerase II, postsynapse to nucleus signaling pathway, postsynaptic density, protein binding
Bgee · 20
CRTC1 → beta cell, Brodmann area 10, cerebellar cortex, cerebellar vermis, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, frontal pole, genital tubercle, hippocampus proper, lumbar subsegment of spinal cord, middle frontal gyrus, neural layer of retina, nucleus accumbens, paraflocculus of cerebellum, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, superior frontal gyrus, tail of embryo, zygote
RNA expression pattern · 20
CRTC1 → beta cell, Brodmann area 10, cerebellar cortex, cerebellar vermis, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, frontal pole, genital tubercle, hippocampus proper, lumbar subsegment of spinal cord, middle frontal gyrus, neural layer of retina, nucleus accumbens, paraflocculus of cerebellum, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, superior frontal gyrus, tail of embryo, zygote
related to External links · 8
CRTC1 → Human CRTC1, Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, UCSC Genome Browser, United States National Library
Band · 2
CRTC1 → 19p13.11, 8|8 B3.3
Chr. · 2
CRTC1 → Chromosome 19 (human), Chromosome 8 (mouse)
End · 2
CRTC1 → 18,782,333 bp, 70,892,229 bp
related to Clinical significance · 2
CRTC1 → Alzheimer's, Production
Aliases · 1
CRTC1 → CRTC1, MECT1, TORC-1, TORC1, WAMTP1, CREB regulated transcription coactivator 1, MAML2, Mam-2
BioGPS · 1
CRTC1 → More reference expression data

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Important terminology

human bp gene chr band transcription chromosome 19 location creb protein mouse coactivator torc1 regulated activity expressed external 782 333

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CRTC1AliasesCRTC1, MECT1, TORC-1, TORC1, WAMTP1, CREB regulated transcription coactivator 1, MAML2, Mam-21.00infobox
CRTC1Band19p13.111.00infobox
CRTC1Band8|8 B3.31.00infobox
CRTC1Bgeebeta cell1.00infobox
CRTC1Bgeeparaflocculus of cerebellum1.00infobox
CRTC1Bgeeright hemisphere of cerebellum1.00infobox
CRTC1BgeeBrodmann area 101.00infobox
CRTC1Bgeemiddle frontal gyrus1.00infobox
CRTC1Bgeefrontal pole1.00infobox
CRTC1Bgeecerebellar vermis1.00infobox
CRTC1Bgeeright frontal lobe1.00infobox
CRTC1Bgeenucleus accumbens1.00infobox
CRTC1Bgeecingulate gyrus1.00infobox
CRTC1Bgeesuperior frontal gyrus1.00infobox
CRTC1Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
CRTC1Bgeeprimary visual cortex1.00infobox
CRTC1Bgeegenital tubercle1.00infobox
CRTC1Bgeelumbar subsegment of spinal cord1.00infobox
CRTC1Bgeetail of embryo1.00infobox
CRTC1Bgeeneural layer of retina1.00infobox
CRTC1Bgeecerebellar cortex1.00infobox
CRTC1Bgeehippocampus proper1.00infobox
CRTC1Bgeezygote1.00infobox
CRTC1BioGPSMore reference expression data1.00infobox
CRTC1Chr.Chromosome 19 (human)1.00infobox
CRTC1Chr.Chromosome 8 (mouse)1.00infobox
CRTC1DatabasesNCBI: entry; OMA: entry1.00infobox
CRTC1End18,782,333 bp1.00infobox
CRTC1End70,892,229 bp1.00infobox
CRTC1EnsemblENSG000001056621.00infobox

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