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Testolactone

Testolactone (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name) (brand name Teslac) is a non-selective, irreversible, steroidal aromatase inhibitor which is used as an antineoplastic drug to treat advanced-stage breast cancer. The drug was discontinued in 2008 and is no longer available for medical use.

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Pharmacology

AromataseSteroid hormoneAdrenal glandsGonadsPostmenopausal
13 related topics

Medical uses

MenopauseOvariesProductionEstrogensGrowth
12 related topics

Side effects

Vaginal dischargeGlossitisEdemaParesthesiaErythema
6 related topics

History

United States
1 related topics

Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Consumer Drug Information
ATC code
none
CAS Number
968-93-4 Y
ChEBI
CHEBI:9460 N
ChEMBL
ChEMBL1571 N

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Overview

Medical uses

Side effects

Pharmacology

Chemistry

History

Advanced semantic analysis

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Map overview Semantic statistics

Testolactone

Nodes52
Edges51
Triples38
Avg. degree1.96
Density0.038462
Components1

How this topic connects Entity context

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Testolactone

Top relations

related to Pharmacology · 7
Testolactone → Androstenedione, AR, However, In, Ki, The, This
related to Chemistry · 2
Testolactone → D-homo-18-oxo, D-ring
related to Medical uses · 2
Testolactone → In, It
3D model (JSmol) · 1
Testolactone → Interactive image
AHFS/Drugs.com · 1
Testolactone → Consumer Drug Information
ATC code · 1
Testolactone → none
CAS Number · 1
Testolactone → 968-93-4 Y
ChEBI · 1
Testolactone → CHEBI:9460 N
ChEMBL · 1
Testolactone → ChEMBL1571 N
ChemSpider · 1
Testolactone → 13172 N

Important terminology Word statistics

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Important terminology

aromatase drug used breast estrogen medical inhibitor also cancer use side effects available 100 name teslac irreversible women mg synthesis

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Testolactone3D model (JSmol)Interactive image1.00infobox
TestolactoneAHFS/Drugs.comConsumer Drug Information1.00infobox
TestolactoneATC codenone1.00infobox
TestolactoneCAS Number968-93-4 Y1.00infobox
TestolactoneChEBICHEBI:9460 N1.00infobox
TestolactoneChEMBLChEMBL1571 N1.00infobox
TestolactoneChemSpider13172 N1.00infobox
TestolactoneCompTox Dashboard (EPA)DTXSID20236441.00infobox
TestolactoneDrug classAromatase inhibitor; Antiestrogen1.00infobox
TestolactoneDrugBankDB00894 Y1.00infobox
TestolactoneECHA InfoCard100.012.3041.00infobox
TestolactoneExcretionUrine1.00infobox
TestolactoneFormulaC19H24O31.00infobox
TestolactoneIUPHAR/BPS73031.00infobox
TestolactoneKEGGD00153 Y1.00infobox
TestolactoneMetabolismLiver1.00infobox
TestolactoneMolar mass300.398 g·mol−11.00infobox
TestolactoneOther names13-Hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acid δ-lactone; SQ-9538; Fludestrin; NSC-12173; NSC-237591.00infobox
TestolactoneProtein binding~85%1.00infobox
TestolactonePubChem CID137691.00infobox
TestolactoneRoutes of administrationBy mouth1.00infobox
TestolactoneTrade namesTeslac1.00infobox
TestolactoneUNII6J9BLA949Q1.00infobox

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