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PPT1: Function, Clinical significance & Overview

Palmitoyl-protein thioesterase 1 (PPT-1), also known as palmitoyl-protein hydrolase 1, is an enzyme that in humans is encoded by the PPT1 gene.

Language: English [EN]
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PPT1 topic overview

The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around PPT1.

Related topics
9
Source areas
3
Connected nodes
12
Extracted relationships
117
Concept neighborhoods
9
Bridge connections
12

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 6 topics
Overview · 2 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.1.2.2
3.1.2.22
Aliases
PPT1, CLN1, INCL, PPT, palmitoyl-protein thioesterase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3GRO
Band
1p34.2 · 4 D2.2|4 57.27 cM
Bgee
monocyte · lateral nuclear group of thalamus · retinal pigment epithelium · external globus pallidus · pons

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PPT1 connects Entity context

The extracted context around PPT1 shows recurring relationship patterns in the source. For example, PPT1 → adult locomotory behavior, associative learning, axon, brain development, cellular macromolecule catabolic process, chemical synaptic transmission, cytosol, dendrite, extracellular exosome, extracellular region, extracellular space, fatty-acyl-CoA biosynthetic process, Golgi apparatus, grooming behavior, hydrolase activity, lipid catabolic process, lysosomal lumen, lysosomal lumen acidification, lysosome, lysosome organization Another extracted example is PPT1 → arcuate nucleus, blood, cerebellar cortex, deep cerebellar nuclei, dorsal tegmental nucleus, external globus pallidus, globus pallidus, granulocyte, lateral nuclear group of thalamus, medial vestibular nucleus, median eminence, monocyte, parotid gland, pars compacta, pars reticulata, pons, pontine nuclei, retinal pigment epithelium, right kidney, seminiferous tubule. Use these groups to spot repeated connection types before inspecting the individual relationships.

PPT1

Top relations

Gene ontology · 50
PPT1 → adult locomotory behavior, associative learning, axon, brain development, cellular macromolecule catabolic process, chemical synaptic transmission, cytosol, dendrite, extracellular exosome, extracellular region, extracellular space, fatty-acyl-CoA biosynthetic process, Golgi apparatus, grooming behavior, hydrolase activity, lipid catabolic process, lysosomal lumen, lysosomal lumen acidification, lysosome, lysosome organization
Bgee · 20
PPT1 → arcuate nucleus, blood, cerebellar cortex, deep cerebellar nuclei, dorsal tegmental nucleus, external globus pallidus, globus pallidus, granulocyte, lateral nuclear group of thalamus, medial vestibular nucleus, median eminence, monocyte, parotid gland, pars compacta, pars reticulata, pons, pontine nuclei, retinal pigment epithelium, right kidney, seminiferous tubule
RNA expression pattern · 20
PPT1 → arcuate nucleus, blood, cerebellar cortex, deep cerebellar nuclei, dorsal tegmental nucleus, external globus pallidus, globus pallidus, granulocyte, lateral nuclear group of thalamus, medial vestibular nucleus, median eminence, monocyte, parotid gland, pars compacta, pars reticulata, pons, pontine nuclei, retinal pigment epithelium, right kidney, seminiferous tubule
Band · 2
PPT1 → 1p34.2, 4 D2.2|4 57.27 cM
Chr. · 2
PPT1 → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
PPT1 → 122,752,968 bp, 40,097,260 bp
3.1.2.2 · 1
PPT1 → ↗
3.1.2.22 · 1
PPT1 → ↗
Aliases · 1
PPT1 → PPT1, CLN1, INCL, PPT, palmitoyl-protein thioesterase 1
Available structures · 1
PPT1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3GRO

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene chr human band chromosome thioesterase enzyme external location ppt-1 mouse palmitoyl-protein hydrolase function search activity 097 260 end

PPT1 relationships Subject–Predicate–Object triples

TTTA extracted 117 structured relationships around PPT1. Examples in this analysis include PPT1 → 3.1.2.2 → ↗ and PPT1 → Aliases → PPT1, CLN1, INCL, PPT, palmitoyl-protein thioesterase 1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PPT13.1.2.21.00infobox
PPT13.1.2.221.00infobox
PPT1AliasesPPT1, CLN1, INCL, PPT, palmitoyl-protein thioesterase 11.00infobox
PPT1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3GRO1.00infobox
PPT1Band1p34.21.00infobox
PPT1Band4 D2.2|4 57.27 cM1.00infobox
PPT1Bgeemonocyte1.00infobox
PPT1Bgeelateral nuclear group of thalamus1.00infobox
PPT1Bgeeretinal pigment epithelium1.00infobox
PPT1Bgeeexternal globus pallidus1.00infobox
PPT1Bgeepons1.00infobox
PPT1Bgeegranulocyte1.00infobox
PPT1Bgeeparotid gland1.00infobox
PPT1Bgeepars compacta1.00infobox
PPT1Bgeeblood1.00infobox
PPT1Bgeepars reticulata1.00infobox
PPT1Bgeemedial vestibular nucleus1.00infobox
PPT1Bgeedeep cerebellar nuclei1.00infobox
PPT1Bgeeseminiferous tubule1.00infobox
PPT1Bgeeright kidney1.00infobox
PPT1Bgeepontine nuclei1.00infobox
PPT1Bgeedorsal tegmental nucleus1.00infobox
PPT1Bgeecerebellar cortex1.00infobox
PPT1Bgeemedian eminence1.00infobox
PPT1Bgeeglobus pallidus1.00infobox
PPT1Bgeearcuate nucleus1.00infobox
PPT1BioGPSn/a1.00infobox
PPT1Chr.Chromosome 1 (human)1.00infobox
PPT1Chr.Chromosome 4 (mouse)1.00infobox
PPT1DatabasesNCBI: entry; OMA: entry1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PPT1 bring nearby vocabulary together. In this analysis, examples include Thioesterase, Activity and External. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Location
    • Ppt1
    • Chromosome
    • Human
    • Thioesterase
    • Bp
    • Chr
    • Activity
    • Cln1
    • D2
    • End
    • External
  • palmitoyl protein thioesterase
    • Protein
    • Ppt1
    • Activity
    • Entry
    • External
    • Function
    • Gene
    • Hydrolase
    • Ncbi
    • Palmitoyl-protein
    • Search
    • Enzyme
  • function
    • Activity
    • External
    • Search
    • Location
    • Ppt1
    • Chromosome
    • Human
    • Palmitoyl
    • Protein
    • Significance
    • Thioesterase
    • Bp
  • PPT1
    • Thioesterase
    • Activity
    • External
    • Function
    • Search
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Clinical
    • Palmitoyl
  • ppt1
    • Thioesterase
    • Activity
    • External
    • Function
    • Search
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Clinical
    • Palmitoyl
  • enzyme
    • Palmitoyl-protein
    • Ppt1
    • Thioesterase
    • Clinical
    • Encoded
    • Gene
    • Humans
    • Known
    • Significance
    • Activity
    • Cln1
    • External
  • clinical significance
    • Significance
    • Activity
    • Cln1
    • External
    • Function
    • Palmitoyl-protein
    • Search
    • Enzyme
    • Location
    • Ppt1
    • Chromosome
    • Human
  • lysosomal
    • Ppt-1
    • Palmitoyl
    • Protein
    • Entry
    • Mouse
    • Ncbi
    • Search
    • Ppt1
    • Thioesterase

Connections between topic areas Semantic bridges

For PPT1, one of the stronger structural bridges in this analysis connects PPT1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PPT1Function · splits 6 ⟂ 7
PPT1Overview · splits 10 ⟂ 3

Map overview Semantic statistics

PPT1

Nodes13
Edges12
Triples117
Avg. degree1.85
Density0.153846
Components1

Source & methodology

TTTA analyzes the structure around PPT1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PPT1 · EN edition · Analysis: TopicsToTalkAbout

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