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Poloxamer: Applications, Uses & Micellization and phase transitions

Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word poloxamer was coined by BASF inventor, Irving Schmolka, who received the patent for these materials in 1973. Poloxamers are also known by the…

Language: English [EN]
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Poloxamer topic overview

The analysis highlights Applications, Uses and Micellization and phase transitions as prominent areas in the source structure around Poloxamer.

Related topics
27
Source areas
4
Connected nodes
31
Extracted relationships
52
Concept neighborhoods
14
Bridge connections
31

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 9 topics
Uses · 8 topics
Micellization and phase transitions · 7 topics
Biological effect · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Micellization and phase transitions

Uses

Biological effect

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Poloxamer connects Entity context

The extracted context around Poloxamer shows recurring relationship patterns in the source. For example, Poloxamer → Above, An, At, Concentrated, PPO, The, This, Thus Another extracted example is Poloxamer → Among, Because, Bio, For, In, Kolliphor, There, They. Use these groups to spot repeated connection types before inspecting the individual relationships.

Poloxamer

Top relations

related to Micellization and phase transitions · 8
Poloxamer → Above, An, At, Concentrated, PPO, The, This, Thus
related to Uses · 8
Poloxamer → Among, Because, Bio, For, In, Kolliphor, There, They
related to On multi drug resistant cancer cells · 6
Poloxamer → Another, ATP, IV, MDR, Poloxamers, The
related to Further reading · 5
Poloxamer → Gonjari ID, Hosmani AH, Karmarkar AB, Pharmacy Student Articles, Poloxamers
related to Potential degradation by sonication · 5
Poloxamer → Moreover, MWNTs, Pluronic F-127, Pluronic F-68, Wang
related to On nuclear factor kappa B · 4
Poloxamer → Certain, L61, NF, P85
related to Biological effect · 3
Poloxamer → Kabanov, The, Work
related to External links · 3
Poloxamer → Healing Injury, Revolutionary Approach, Video Poloxamer-188

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

poloxamers polyoxyethylene polyoxypropylene also temperature two cells shown copolymers pluronic hydrophobic polymers molecular water increase used polymer blocks different synperonic

Poloxamer relationships Subject–Predicate–Object triples

TTTA extracted 52 structured relationships around Poloxamer. Examples in this analysis include the formation of highly ordered mesophases → instance of → other phenomena can occur and salts → instance of → This is due to the fact that hydrogen bonding between the polyoxyethylene and the water molecules breaks down at high temperature and polyoxyethylene becomes also insoluble in w…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
the formation of highly ordered mesophasesinstance ofother phenomena can occur0.80text
saltsinstance ofThis is due to the fact that hydrogen bonding between the polyoxyethylene and the water molecules breaks down at high temperature and polyoxyethylene becomes also insoluble in w…0.80text
alcoholsinstance ofThis is due to the fact that hydrogen bonding between the polyoxyethylene and the water molecules breaks down at high temperature and polyoxyethylene becomes also insoluble in w…0.80text
Pluronic F-108 or Pluronic F-127instance ofcertain poloxamers0.80text
are used as steric stabilizers to prevent coalescence and/or reduce aggregationinstance ofcertain poloxamers0.80text
doxorubicin.Another effect of the polymers upon cancer cells is the inhibition of the production of ATP in multi-drug resistantinstance ofthe MDR proteins are responsible for the efflux of drugs from the cells and hence increase the susceptibility of cancer cells to chemotherapeutic agents0.80text
P85 have been shown not only to be able to transport target genes to target cellsinstance ofand abolish drug sequestering within cytoplasmic vesicles.On nuclear factor kappa BCertain poloxamers0.80text
but also to increase gene expressioninstance ofand abolish drug sequestering within cytoplasmic vesicles.On nuclear factor kappa BCertain poloxamers0.80text
P85 have been shown not only to be able to transport target genes to target cellsinstance ofOn nuclear factor kappa BCertain poloxamers0.80text
but also to increase gene expressioninstance ofOn nuclear factor kappa BCertain poloxamers0.80text
Poloxamerrelated to Biological effectWork0.60section
Poloxamerrelated to Biological effectKabanov0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Poloxamer bring nearby vocabulary together. In this analysis, examples include Content, Mass and Molecular. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • copolymers
    • Content
    • First
    • Followed
    • Mass
    • Two
    • Polyoxyethylene
    • Polyoxypropylene
    • Micelle
    • Molecular
    • Temperature
    • Concentration
    • Hydrophilic
  • Poloxamer
    • Content
    • Mass
    • Molecular
    • Solutions
    • Polyoxyethylene
    • Polyoxypropylene
    • Cells
    • L61
    • Properties
    • Synperonic
    • Micellization
    • Phase
  • poloxamer
    • Content
    • Mass
    • Molecular
    • Solutions
    • Polyoxyethylene
    • Polyoxypropylene
    • Cells
    • L61
    • Properties
    • Synperonic
    • Micellization
    • Phase
  • polyoxypropylene
    • Polyoxyethylene
    • Content
    • Mass
    • Molecular
    • Blocks
    • Two
    • First
    • Followed
    • Poloxamer
    • Temperature
    • L61
    • Synperonic
  • micellization and phase transitions
    • Transitions
    • Unimers
    • Properties
    • Phase
    • Solutions
    • Cancer
    • Drug
    • Effect
    • Polymer
    • Poloxamer
    • Two
    • Polyoxyethylene
  • polyoxyethylene
    • Polyoxypropylene
    • Content
    • Mass
    • Molecular
    • Blocks
    • Two
    • First
    • Followed
    • Poloxamer
    • Temperature
    • L61
    • Synperonic
  • hydrophobic
    • Hydrophilic
    • Two
    • Block
    • Polymer
    • Polyoxypropylene
    • Molecular
    • Concentration
    • Different
    • Transitions
    • Increase
    • Used
    • Water
  • micellization
    • Unimers
    • Properties
    • Phase
    • Solutions
    • Cancer
    • Drug
    • Effect
    • Polymer
    • Transitions
    • Poloxamer
    • Two
    • Cells

Connections between topic areas Semantic bridges

For Poloxamer, one of the stronger structural bridges in this analysis connects Poloxamer with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PoloxamerOverview · splits 22 ⟂ 10
PoloxamerUses · splits 23 ⟂ 9
PoloxamerMicellization and phase transitions · splits 24 ⟂ 8
PoloxamerBiological effect · splits 28 ⟂ 4

Map overview Semantic statistics

Poloxamer

Nodes32
Edges31
Triples52
Avg. degree1.94
Density0.0625
Components1

Source & methodology

TTTA analyzes the structure around Poloxamer to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Uses & Micellization and phase transitions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Poloxamer · EN edition · Analysis: TopicsToTalkAbout

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