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Fibrocystin

Fibrocystin is a large, receptor-like protein that is thought to be involved in the tubulogenesis and/or maintenance of duct-lumen architecture of epithelium. FPC associates with the primary cilia of epithelial cells and co-localizes with the Pkd2 gene product polycystin-2 (PC2), suggesting that these two proteins may function in a common molecular pathway.

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Pathology

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Key facts & relationships

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AlphaFold
IPR029927
Available protein structures:
IPR029927
InterPro
IPR029927
Membranome
632
PDB
IPR029927
Symbol
Fibrocystin

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Overview

Pathology

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Map overview Semantic statistics

Fibrocystin

Nodes6
Edges5
Triples20
Avg. degree1.67
Density0.333333
Components1

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Fibrocystin

Top relations

related to External links · 6
Fibrocystin → Autosomal Recessivefibrocystin, GeneReviews/NIH/NCBI/UW, Medicine Medical Subject Headings, MeSH, National Library, Polycystic Kidney Disease
related to Pathology · 6
Fibrocystin → ARPKD, Israeli Bedouins, Morover, Mutations, PKHD1, While
AlphaFold · 1
Fibrocystin → IPR029927
Available protein structures: · 1
Fibrocystin → IPR029927
InterPro · 1
Fibrocystin → IPR029927
Membranome · 1
Fibrocystin → 632
PDB · 1
Fibrocystin → IPR029927
Symbol · 1
Fibrocystin → Fibrocystin
causes · 1
Fibrocystin → characteristic polycystic dilation of both structures.PKHD1 is a relatively large gene
is a · 1
Fibrocystin → large

Important terminology Word statistics

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Important terminology

protein pkhd1 gene mutations autosomal recessive polycystic disease large epithelial may structures epithelium cause kidney arpkd alternatively shown coding receptor-like

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
FibrocystinAlphaFoldIPR0299271.00infobox
FibrocystinAvailable protein structures:IPR0299271.00infobox
FibrocystinInterProIPR0299271.00infobox
FibrocystinMembranome6321.00infobox
FibrocystinPDBIPR0299271.00infobox
FibrocystinSymbolFibrocystin1.00infobox
Fibrocystincausescharacteristic polycystic dilation of both structures.PKHD1 is a relatively large gene0.90text
Fibrocystinis alarge0.90text
Fibrocystinrelated to External linksGeneReviews/NIH/NCBI/UW0.60section
Fibrocystinrelated to External linksPolycystic Kidney Disease0.60section
Fibrocystinrelated to External linksAutosomal Recessivefibrocystin0.60section
Fibrocystinrelated to External linksNational Library0.60section

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