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Drug tolerance

Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use. Drug tolerance develops gradually over time. Increasing its dosage may re-amplify the drug's effects; however, this may accelerate tolerance, further reducing the drug's effects. Drug tolerance is indicative of…

Overview, Pharmacokinetic (metabolic) tolerance & Pharmacodynamic tolerance

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Overview

PharmacologicalDrug dependenceAddictionDrug holidayPhysiological
16 related topics

Pharmacokinetic (metabolic) tolerance

InductionEthanolFirst-pass metabolism
3 related topics

Pharmacodynamic tolerance

ReceptorReceptor antagonist
2 related topics

Tachyphylaxis

Tachyphylaxis
1 related topics

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Overview

Tachyphylaxis

Pharmacodynamic tolerance

Pharmacokinetic (metabolic) tolerance

Behavioral tolerance

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Map overview Semantic statistics

Drug tolerance

Nodes29
Edges28
Triples5
Avg. degree1.93
Density0.068966
Components1

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Drug tolerance

Top relations

related to Tachyphylaxis · 3
Drug tolerance → Tachyphylaxis, The, This

Important terminology Word statistics

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Important terminology

tolerance drug use repeated effect may increase addiction effects pharmacodynamic dependence reverse sensitization drugs substance one behavioral occur tachyphylaxis psychological

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ethanol.This type of tolerance is most evident with oral ingestioninstance ofThis is most commonly seen with substances0.80text
because other routes of drug administration bypass first-pass metabolisminstance ofThis is most commonly seen with substances0.80text
Drug tolerancerelated to TachyphylaxisTachyphylaxis0.60section
Drug tolerancerelated to TachyphylaxisThis0.60section
Drug tolerancerelated to TachyphylaxisThe0.60section

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    Min side: 3
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