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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene.
The analysis highlights Research, Inhibitors and Overview as prominent areas in the source structure around PDE10A.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around PDE10A shows recurring relationship patterns in the source. For example, PDE10A → 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cAMP binding, cAMP catabolic process, catalytic activity, cGMP binding, cGMP catabolic process, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity, cyclic-nucleotide phosphodiesterase activity, cytoplasm, cytosol, G protein-coupled receptor signaling pathway, hydrolase activity, membrane, metabolism, metal ion binding, negative regulation of cAMP-mediated signaling, negative regulation of cGMP-mediated signaling, nucleotide binding Another extracted example is PDE10A → amygdala, anterior amygdaloid area, anterior pituitary, cartilage tissue, caudate nucleus, cerebellar vermis, corpus epididymis, external globus pallidus, globus pallidus, lateral septal nucleus, left ovary, left uterine tube, lobe of cerebellum, nucleus accumbens, olfactory tubercle, putamen, right ovary, stromal cell of endometrium, superior frontal gyrus, temporal lobe. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
bp chr human band gene camp cgmp chromosome phosphodiesterase signaling 17 location enzyme mouse 3' 10a cellular cgmp-mediated nucleotide humans
TTTA extracted 98 structured relationships around PDE10A. Examples in this analysis include PDE10A → 3.1.4.17 → ↗ and PDE10A → Aliases → PDE10A, HSPDE10A19, ADSD2, IOLOD, phosphodiesterase 10A, LINC00473. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| PDE10A | 3.1.4.17 | ↗ | 1.00 | infobox |
| PDE10A | Aliases | PDE10A, HSPDE10A19, ADSD2, IOLOD, phosphodiesterase 10A, LINC00473 | 1.00 | infobox |
| PDE10A | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2OUN, 2OUP, 2OUQ, 2OUR, 2OUS, 2OUU, 2OUV, 2OUY, 2WEY, 2Y0J, 2ZMF, 3SN7, 3SNI, 3SNL, 3UI7, 3UUO, 3WI2, 3WS8,… | 1.00 | infobox |
| PDE10A | Band | 6q27 | 1.00 | infobox |
| PDE10A | Band | 17|17 A1 | 1.00 | infobox |
| PDE10A | Bgee | left uterine tube | 1.00 | infobox |
| PDE10A | Bgee | cartilage tissue | 1.00 | infobox |
| PDE10A | Bgee | left ovary | 1.00 | infobox |
| PDE10A | Bgee | external globus pallidus | 1.00 | infobox |
| PDE10A | Bgee | corpus epididymis | 1.00 | infobox |
| PDE10A | Bgee | putamen | 1.00 | infobox |
| PDE10A | Bgee | right ovary | 1.00 | infobox |
| PDE10A | Bgee | anterior pituitary | 1.00 | infobox |
| PDE10A | Bgee | stromal cell of endometrium | 1.00 | infobox |
| PDE10A | Bgee | caudate nucleus | 1.00 | infobox |
| PDE10A | Bgee | olfactory tubercle | 1.00 | infobox |
| PDE10A | Bgee | nucleus accumbens | 1.00 | infobox |
| PDE10A | Bgee | globus pallidus | 1.00 | infobox |
| PDE10A | Bgee | superior frontal gyrus | 1.00 | infobox |
| PDE10A | Bgee | temporal lobe | 1.00 | infobox |
| PDE10A | Bgee | amygdala | 1.00 | infobox |
| PDE10A | Bgee | lobe of cerebellum | 1.00 | infobox |
| PDE10A | Bgee | cerebellar vermis | 1.00 | infobox |
| PDE10A | Bgee | anterior amygdaloid area | 1.00 | infobox |
| PDE10A | Bgee | lateral septal nucleus | 1.00 | infobox |
| PDE10A | BioGPS | More reference expression data | 1.00 | infobox |
| PDE10A | Chr. | Chromosome 6 (human) | 1.00 | infobox |
| PDE10A | Chr. | Chromosome 17 (mouse) | 1.00 | infobox |
| PDE10A | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| PDE10A | End | 165,988,117 bp | 1.00 | infobox |
The concept neighborhoods around PDE10A bring nearby vocabulary together. In this analysis, examples include Phosphodiesterase, Signaling and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For PDE10A, one of the stronger structural bridges in this analysis connects PDE10A with Inhibitors. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around PDE10A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Inhibitors & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — PDE10A · EN edition · Analysis: TopicsToTalkAbout