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PDE10A

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene.

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Inhibitors

6 related topics

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2 related topics

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5 related topics

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3.1.4.17
Aliases
PDE10A, HSPDE10A19, ADSD2, IOLOD, phosphodiesterase 10A, LINC00473
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2OUN, 2OUP, 2OUQ, 2OUR, 2OUS, 2OUU, 2OUV, 2OUY, 2WEY, 2Y0J, 2ZMF, 3SN7, 3SNI, 3SNL, 3UI7, 3UUO, 3WI2, 3WS8,…
Band
6q27 · 17|17 A1
Bgee
left uterine tube · cartilage tissue · left ovary · external globus pallidus · corpus epididymis
BioGPS
More reference expression data

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Map overview Semantic statistics

PDE10A

Nodes17
Edges16
Triples98
Avg. degree1.88
Density0.117647
Components1

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PDE10A

Top relations

Gene ontology · 26
PDE10A → 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cAMP binding, cAMP catabolic process, catalytic activity, cGMP binding, cGMP catabolic process, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity, cyclic-nucleotide phosphodiesterase activity, cytoplasm, cytosol, G protein-coupled receptor signaling pathway, hydrolase activity, membrane, metabolism, metal ion binding, negative regulation of cAMP-mediated signaling, negative regulation of cGMP-mediated signaling, nucleotide binding
Bgee · 20
PDE10A → amygdala, anterior amygdaloid area, anterior pituitary, cartilage tissue, caudate nucleus, cerebellar vermis, corpus epididymis, external globus pallidus, globus pallidus, lateral septal nucleus, left ovary, left uterine tube, lobe of cerebellum, nucleus accumbens, olfactory tubercle, putamen, right ovary, stromal cell of endometrium, superior frontal gyrus, temporal lobe
RNA expression pattern · 20
PDE10A → amygdala, anterior amygdaloid area, anterior pituitary, cartilage tissue, caudate nucleus, cerebellar vermis, corpus epididymis, external globus pallidus, globus pallidus, lateral septal nucleus, left ovary, left uterine tube, lobe of cerebellum, nucleus accumbens, olfactory tubercle, putamen, right ovary, stromal cell of endometrium, superior frontal gyrus, temporal lobe
related to Research · 6
PDE10A → Dysfunction, February, Inhibition, MK-8189, Phase, Preliminary
Band · 2
PDE10A → 17|17 A1, 6q27
Chr. · 2
PDE10A → Chromosome 17 (mouse), Chromosome 6 (human)
End · 2
PDE10A → 165,988,117 bp, 9,205,480 bp
3.1.4.17 · 1
PDE10A → ↗
Aliases · 1
PDE10A → PDE10A, HSPDE10A19, ADSD2, IOLOD, phosphodiesterase 10A, LINC00473
Available structures · 1
PDE10A → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2OUN, 2OUP, 2OUQ, 2OUR, 2OUS, 2OUU, 2OUV, 2OUY, 2WEY, 2Y0J, 2ZMF, 3SN7, 3SNI, 3SNL, 3UI7, 3UUO, 3WI2, 3WS8,…

Important terminology Word statistics

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Important terminology

bp chr human band gene camp cgmp chromosome phosphodiesterase signaling 17 location enzyme mouse 3' 10a cellular cgmp-mediated nucleotide humans

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PDE10A3.1.4.171.00infobox
PDE10AAliasesPDE10A, HSPDE10A19, ADSD2, IOLOD, phosphodiesterase 10A, LINC004731.00infobox
PDE10AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2OUN, 2OUP, 2OUQ, 2OUR, 2OUS, 2OUU, 2OUV, 2OUY, 2WEY, 2Y0J, 2ZMF, 3SN7, 3SNI, 3SNL, 3UI7, 3UUO, 3WI2, 3WS8,…1.00infobox
PDE10ABand6q271.00infobox
PDE10ABand17|17 A11.00infobox
PDE10ABgeeleft uterine tube1.00infobox
PDE10ABgeecartilage tissue1.00infobox
PDE10ABgeeleft ovary1.00infobox
PDE10ABgeeexternal globus pallidus1.00infobox
PDE10ABgeecorpus epididymis1.00infobox
PDE10ABgeeputamen1.00infobox
PDE10ABgeeright ovary1.00infobox
PDE10ABgeeanterior pituitary1.00infobox
PDE10ABgeestromal cell of endometrium1.00infobox
PDE10ABgeecaudate nucleus1.00infobox
PDE10ABgeeolfactory tubercle1.00infobox
PDE10ABgeenucleus accumbens1.00infobox
PDE10ABgeeglobus pallidus1.00infobox
PDE10ABgeesuperior frontal gyrus1.00infobox
PDE10ABgeetemporal lobe1.00infobox
PDE10ABgeeamygdala1.00infobox
PDE10ABgeelobe of cerebellum1.00infobox
PDE10ABgeecerebellar vermis1.00infobox
PDE10ABgeeanterior amygdaloid area1.00infobox
PDE10ABgeelateral septal nucleus1.00infobox
PDE10ABioGPSMore reference expression data1.00infobox
PDE10AChr.Chromosome 6 (human)1.00infobox
PDE10AChr.Chromosome 17 (mouse)1.00infobox
PDE10ADatabasesNCBI: entry; OMA: entry1.00infobox
PDE10AEnd165,988,117 bp1.00infobox

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