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Clobazam

Clobazam, sold under the brand names Frisium and Onfi, among others, is a long-acting benzodiazepine medication primarily used as an anxiolytic and anticonvulsant. Clobazam is a 1,5-benzodiazepine with unique pharmacological characteristics that was patented in 1968. Clobazam was first synthesized in 1966 and first published in 1969. It was approved in…

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3D model (JSmol)
Interactive image
Addiction liability
High[citation needed]
AHFS/Drugs.com
Monograph
ATC code
N05BA09 (WHO)
Bioavailability
Rapidly and extensively absorbed; 87%–95% (oral)
CAS Number
22316-47-8

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Overview

Medical uses

Side effects

Pharmacology

Chemistry

History

Society and culture

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Map overview Semantic statistics

Clobazam

Nodes97
Edges96
Triples99
Avg. degree1.98
Density0.020619
Components1

How this topic connects Entity context

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Clobazam

Top relations

related to Pharmacology · 11
Clobazam → Cl, CP-1414S, GABA, GABA-mediated, GABAA, GABAergic, It, Like, N-desmethylclobazam, The, They
related to Metabolism · 10
Clobazam → CYP2B6, CYP2C18, CYP2C19, CYP3A4, Hydroxy-N-desmethylclobazam, Hydroxyclobazam, Hydroxyclobazam The, N-desmethylclobazam, The, While
Legal status · 9
Clobazam → AU: S4 (Prescription only), BR: Class B1 (Psychoactive drugs), CA: Schedule IV, DE: Prescription only (Anlage III for higher doses), In general: ℞ (Prescription only), NZ: Class C, UK: Class C, UN: Psychotropic Schedule IV, US: Schedule IV
Metabolites · 6
Clobazam → • 4'-Hydroxy-N-desmethylclobazam, • 4'-Hydroxyclobazam, • 9-Hydroxy-N-desmethylclobazam, • N-desmethylclobazam (Norclobazam, 4-oxo-Lofendazam), • N-desmethylclobazam (Norclobazam, 4-oxo-Lofendazam) • N-desmethylclobazam-3',4'-dihydrodiol • 9-Hydroxy-N-desmethylclobazam • 4'-Hydroxy-N-desmethylclobazam • 4'-Hydroxyclobazam, • N-desmethylclobazam-3',4'-dihydrodiol
related to history · 5
Clobazam → Maestretti, Maestretti Research Laboratories, Milan, Roussel Uclaf, Sanofi
related to Anxiety · 4
Clobazam → Frisium, In, It, United Kingdom
related to Dependence and withdrawal · 4
Clobazam → Benzodiazepine, In, The, Withdrawal
related to Epilepsy · 4
Clobazam → As, Canada, Frisium, It
related to Warnings and precautions · 4
Clobazam → FDA, In December, Johnson, Stevens
Excretion · 3
Clobazam → Feces (11%), Kidney (82%), Kidney (82%) Feces (11%)

Important terminology Word statistics

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Important terminology

benzodiazepine drug approved effects anxiety n-desmethylclobazam epilepsy gabaa receptor use syndrome therapy anticonvulsant withdrawal seizures dependence benzodiazepines addiction metabolite onfi

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Clobazam3D model (JSmol)Interactive image1.00infobox
ClobazamAddiction liabilityHigh[citation needed]1.00infobox
ClobazamAHFS/Drugs.comMonograph1.00infobox
ClobazamATC codeN05BA09 (WHO)1.00infobox
ClobazamBioavailabilityRapidly and extensively absorbed; 87%–95% (oral)1.00infobox
ClobazamCAS Number22316-47-81.00infobox
ClobazamChEBICHEBI:314131.00infobox
ClobazamChEMBLChEMBL704181.00infobox
ClobazamChemSpider26871.00infobox
ClobazamCompTox Dashboard (EPA)DTXSID20467591.00infobox
ClobazamDependence liabilityHigh[citation needed]1.00infobox
ClobazamDrug classBenzodiazepine, Anticonvulsant1.00infobox
ClobazamDrugBankDB003491.00infobox
ClobazamECHA InfoCard100.040.8101.00infobox
ClobazamElimination half-life• Clobazam: 36–42 hours • N-desmethylclobazam: 71–82 hours1.00infobox
ClobazamElimination half-life• Clobazam: 36–42 hours1.00infobox
ClobazamExcretionKidney (82%) Feces (11%)1.00infobox
ClobazamExcretionKidney (82%)1.00infobox
ClobazamExcretionFeces (11%)1.00infobox
ClobazamFormulaC16H13ClN2O21.00infobox
ClobazamIUPHAR/BPS71491.00infobox
ClobazamKEGGD012531.00infobox
ClobazamLegal statusAU: S4 (Prescription only)1.00infobox
ClobazamLegal statusBR: Class B1 (Psychoactive drugs)1.00infobox
ClobazamLegal statusCA: Schedule IV1.00infobox
ClobazamLegal statusDE: Prescription only (Anlage III for higher doses)1.00infobox
ClobazamLegal statusNZ: Class C1.00infobox
ClobazamLegal statusUK: Class C1.00infobox
ClobazamLegal statusUS: Schedule IV1.00infobox
ClobazamLegal statusUN: Psychotropic Schedule IV1.00infobox

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