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ML398: Science & Overview

ML398 is a potent and selective dopamine D4 receptor antagonist which has been used in scientific research. It shows high affinity for the dopamine D4 receptor (Ki = 36 nM) and negligible affinity for the other four dopamine receptors (>20,000 nM). As such, the drug shows more than 100-fold selectivity for the dopamine D4 receptor over the other dopamine…

Language: English [EN]
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ML398 topic overview

The analysis highlights Science and Overview as prominent areas in the source structure around ML398.

Related topics
12
Source areas
1
Connected nodes
13
Extracted relationships
11
Related term clusters
13
Bridge connections
13

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 12 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
None
ChEMBL
ChEMBL3335556
ChemSpider
35033271
Drug class
Dopamine D4 receptor antagonist
Formula
C19H22ClNO

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How ML398 connects Entity context

The extracted context around ML398 shows recurring relationship patterns in the source. For example, ML398 → Interactive image Another extracted example is ML398 → None. Use these groups to spot repeated connection types before inspecting the individual relationships.

ML398

Top relations

3D model (JSmol) · 1
ML398 → Interactive image
ATC code · 1
ML398 → None
ChEMBL · 1
ML398 → ChEMBL3335556
ChemSpider · 1
ML398 → 35033271
Drug class · 1
ML398 → Dopamine D4 receptor antagonist
Formula · 1
ML398 → C19H22ClNO
IUPHAR/BPS · 1
ML398 → 8440
Molar mass · 1
ML398 → 315.84 g·mol−1
Other names · 1
ML398 → ML-398
PubChem CID · 1
ML398 → 72737723

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dopamine d4 receptor antagonist scientific shows receptors described drug potent selective affinity hyperlocomotion used research high ki 36 nm negligible

ML398 relationships Subject–Predicate–Object triples

TTTA extracted 11 structured relationships around ML398. Examples in this analysis include ML398 → 3D model (JSmol) → Interactive image and ML398 → ATC code → None. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ML3983D model (JSmol)Interactive image1.00infobox
ML398ATC codeNone1.00infobox
ML398ChEMBLChEMBL33355561.00infobox
ML398ChemSpider350332711.00infobox
ML398Drug classDopamine D4 receptor antagonist1.00infobox
ML398FormulaC19H22ClNO1.00infobox
ML398IUPHAR/BPS84401.00infobox
ML398Molar mass315.84 g·mol−11.00infobox
ML398Other namesML-3981.00infobox
ML398PubChem CID727377231.00infobox
ML398is apotent and selective dopamine D4 receptor antagonist which has been used in scientific research0.90text

Related concept clusters Related term clusters

The concept neighborhoods around ML398 bring nearby vocabulary together. In this analysis, examples include Antagonist, Described and Scientific. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • dopamine
    • D4
    • Receptor
    • Antagonist
    • Drug
    • Receptors
    • Shows
    • Ml398
    • 100-fold
    • Affinity
    • Four
    • High
    • Ki
  • d4 receptor
    • Dopamine
    • Receptor
    • Antagonist
    • Drug
    • Receptors
    • Shows
    • Ml398
    • 100-fold
    • Affinity
    • Four
    • High
    • Ki
  • dopamine receptors
    • D4
    • Receptor
    • Shows
    • 100-fold
    • Antagonist
    • Drug
    • Receptors
    • Selectivity
    • Ml398
    • Affinity
    • Four
    • High
  • ML398
    • Antagonist
    • Described
    • Scientific
    • D4
    • Dopamine
    • Receptor
    • Chemical
    • Literature
    • Potent
    • References
    • Research
    • Selective
  • ml398
    • Antagonist
    • Described
    • Scientific
    • D4
    • Dopamine
    • Receptor
    • Chemical
    • Literature
    • Potent
    • References
    • Research
    • Selective
  • antagonist
    • D4
    • Dopamine
    • Ml398
    • Potent
    • Receptor
    • References
    • Research
    • Selective
    • Used
    • Drug
    • Scientific
  • affinity
    • Four
    • High
    • Ki
    • Negligible
    • Nm
    • Receptors
    • Shows
    • D4
    • Dopamine
    • Receptor
  • scientific literature
    • Literature
    • Research
    • Scientific
    • Selective
    • Used
    • Described
    • Ml398

Connections between topic areas Semantic bridges

Bridges highlight paths between different parts of the ML398 map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Map overview Semantic statistics

ML398

Nodes14
Edges13
Triples11
Avg. degree1.86
Density0.142857
Components1

Source & methodology

TTTA analyzes the structure around ML398 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Science & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ML398 · EN edition · Analysis: TopicsToTalkAbout

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