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Mibefradil

Mibefradil (trade name Posicor) was a pharmaceutical drug used for the treatment of hypertension and chronic angina pectoris. It is a nonselective calcium channel blocker. It was voluntary pulled from the market ten months after FDA approval, citing potential serious health hazards shown in post release studies.

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Micromedex Detailed Consumer Information
ATC code
C08CX01 (WHO)
Bioavailability
70%
CAS Number
116644-53-2 Y
ChEMBL
ChEMBL45816 N

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Overview

Advanced semantic analysis

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Map overview Semantic statistics

Mibefradil

Nodes9
Edges8
Triples25
Avg. degree1.78
Density0.222222
Components1

How this topic connects Entity context

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Mibefradil

Top relations

3D model (JSmol) · 1
Mibefradil → Interactive image
AHFS/Drugs.com · 1
Mibefradil → Micromedex Detailed Consumer Information
ATC code · 1
Mibefradil → C08CX01 (WHO)
Bioavailability · 1
Mibefradil → 70%
CAS Number · 1
Mibefradil → 116644-53-2 Y
ChEMBL · 1
Mibefradil → ChEMBL45816 N
ChemSpider · 1
Mibefradil → 54673 N
CompTox Dashboard (EPA) · 1
Mibefradil → DTXSID1023318
DrugBank · 1
Mibefradil → DB01388 N
Elimination half-life · 1
Mibefradil → 17–25 hours

Important terminology Word statistics

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Important terminology

market drug calcium voluntary fda approval potential trade name posicor synthesis hypertension t-type l-type roche pharmaceutical used treatment chronic angina

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Mibefradil3D model (JSmol)Interactive image1.00infobox
MibefradilAHFS/Drugs.comMicromedex Detailed Consumer Information1.00infobox
MibefradilATC codeC08CX01 (WHO)1.00infobox
MibefradilBioavailability70%1.00infobox
MibefradilCAS Number116644-53-2 Y1.00infobox
MibefradilChEMBLChEMBL45816 N1.00infobox
MibefradilChemSpider54673 N1.00infobox
MibefradilCompTox Dashboard (EPA)DTXSID10233181.00infobox
MibefradilDrugBankDB01388 N1.00infobox
MibefradilElimination half-life17–25 hours1.00infobox
MibefradilFormulaC29H38FN3O31.00infobox
MibefradilIUPHAR/BPS25221.00infobox
MibefradilKEGGD08217 Y1.00infobox
MibefradilLegal statusWithdrawn from market1.00infobox
MibefradilMedlinePlusa6070071.00infobox
MibefradilMelting point128 °C (262 °F) (dihydrochloride salt)1.00infobox
MibefradilMetabolismLiver (CYP3A4)1.00infobox
MibefradilMolar mass495.639 g·mol−11.00infobox
MibefradilPDB ligandMWV (PDBe, RCSB PDB)1.00infobox
MibefradilProtein binding>99%1.00infobox
MibefradilPubChem CID606621.00infobox
MibefradilRoutes of administrationBy mouth (tablets)1.00infobox
MibefradilTrade namesPosicor1.00infobox
MibefradilUNII27B90X776A1.00infobox

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