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Mecillinam: History & Applications

Mecillinam (INN) or amdinocillin (USAN) is an extended-spectrum penicillin antibiotic of the amidinopenicillin class that binds specifically to penicillin binding protein 2 (PBP2), and is only considered to be active against Gram-negative bacteria. It is used primarily in the treatment of urinary tract infections, and has also been used to treat typhoid…

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Mecillinam topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Mecillinam.

Related topics
25
Source areas
4
Connected nodes
29
Extracted relationships
46
Concept neighborhoods
19
Bridge connections
29

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 12 topics
Medical uses · 7 topics
Adverse effects · 4 topics
History · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
International Drug Names
ATC code
J01CA11 (WHO)
Bioavailability
Negligible
CAS Number
32887-01-7 Y
ChEMBL
ChEMBL530 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Mecillinam connects Entity context

The extracted context around Mecillinam shows recurring relationship patterns in the source. For example, Mecillinam → Another, Brazil, Canada, Escherichia, Europe, European, Gram-negative, Gram-positive, Proteus, Pseudomonas, Several, Staphylococcus, Worldwide Another extracted example is Mecillinam → Danish, FL, It, LEO Pharma, Leo Pharmaceutical Products, With. Use these groups to spot repeated connection types before inspecting the individual relationships.

Mecillinam

Top relations

related to Medical uses · 13
Mecillinam → Another, Brazil, Canada, Escherichia, Europe, European, Gram-negative, Gram-positive, Proteus, Pseudomonas, Several, Staphylococcus, Worldwide
related to history · 6
Mecillinam → Danish, FL, It, LEO Pharma, Leo Pharmaceutical Products, With
Legal status · 3
Mecillinam → AU: S4 (Prescription only), In general: ℞ (Prescription only), UK: POM (Prescription only)
has effect · 2
Mecillinam → Its, The
3D model (JSmol) · 1
Mecillinam → Interactive image
AHFS/Drugs.com · 1
Mecillinam → International Drug Names
ATC code · 1
Mecillinam → J01CA11 (WHO)
Bioavailability · 1
Mecillinam → Negligible
CAS Number · 1
Mecillinam → 32887-01-7 Y
ChEMBL · 1
Mecillinam → ChEMBL530 Y

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bacteria active gram-negative urinary tract bioavailability binding protein coli used treatment infections also low developed adverse effects proteus leo inn

Mecillinam relationships Subject–Predicate–Object triples

TTTA extracted 46 structured relationships around Mecillinam. Examples in this analysis include Mecillinam → 3D model (JSmol) → Interactive image and Mecillinam → AHFS/Drugs.com → International Drug Names. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Mecillinam3D model (JSmol)Interactive image1.00infobox
MecillinamAHFS/Drugs.comInternational Drug Names1.00infobox
MecillinamATC codeJ01CA11 (WHO)1.00infobox
MecillinamBioavailabilityNegligible1.00infobox
MecillinamCAS Number32887-01-7 Y1.00infobox
MecillinamChEMBLChEMBL530 Y1.00infobox
MecillinamChemSpider33357 N1.00infobox
MecillinamCompTox Dashboard (EPA)DTXSID30225841.00infobox
MecillinamDrugBankDB01163 Y1.00infobox
MecillinamECHA InfoCard100.046.6011.00infobox
MecillinamElimination half-life1 to 3 hours1.00infobox
MecillinamExcretionRenal and biliary, mostly unchanged1.00infobox
MecillinamFormulaC15H23N3O3S1.00infobox
MecillinamKEGGD02888 N1.00infobox
MecillinamLegal statusAU: S4 (Prescription only)1.00infobox
MecillinamLegal statusUK: POM (Prescription only)1.00infobox
MecillinamLegal statusIn general: ℞ (Prescription only)1.00infobox
MecillinamMetabolismSome hepatic metabolism1.00infobox
MecillinamMolar mass325.43 g·mol−11.00infobox
MecillinamPregnancy categoryAppears safe in pregnancy1.00infobox
MecillinamProtein binding5 to 10%1.00infobox
MecillinamPubChem CID362731.00infobox
MecillinamRoutes of administrationIntravenous, intramuscular1.00infobox
MecillinamTrade namesCoactin, Leo, Selexid, Selexidin1.00infobox
MecillinamUNIIV10579P3QZ1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Mecillinam bring nearby vocabulary together. In this analysis, examples include Bacteria, Active and Coli. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Mecillinam
    • Bacteria
    • Active
    • Coli
    • Gram-negative
    • Adverse
    • Binding
    • Bioavailability
    • Conducted
    • Developed
    • Escherichia
    • Found
    • Infection
  • mecillinam
    • Bacteria
    • Active
    • Coli
    • Gram-negative
    • Adverse
    • Binding
    • Bioavailability
    • Conducted
    • Developed
    • Escherichia
    • Found
    • Infection
  • penicillin binding protein 2
    • Pbp2
    • Protein
    • Specifically
    • Usan
    • Gram-negative
    • Bacteria
    • Binds
    • Class
    • Extended-spectrum
    • Inn
    • Penicillin
    • Adverse
  • gram-negative bacteria
    • Bacteria
    • Gram-negative
    • Protein
    • Binding
    • Escherichia
    • Proteus
    • Mecillinam
    • Coli
    • Tract
    • Urinary
    • Inn
    • Pbp2
  • urinary tract infections
    • Tract
    • Treatment
    • Urinary
    • Used
    • Escherichia
    • Infections
    • Coli
    • Typhoid
    • Adverse
    • Also
    • Bioavailability
    • Effects
  • escherichia coli
    • Conducted
    • Escherichia
    • Study
    • Tract
    • Urinary
    • Found
    • Infection
    • Infections
    • Leo
    • Low
    • Mecillinam
    • Protein
  • bioavailability
    • Pivmecillinam
    • Prodrug
    • Adverse
    • Developed
    • Effects
    • Escherichia
    • Infections
    • Leo
    • Low
    • Protein
    • Treatment
    • Used
  • inn
    • Amdinocillin
    • Amidinopenicillin
    • Antibiotic
    • Binds
    • Class
    • Extended-spectrum
    • Pbp2
    • Penicillin
    • Specifically
    • Usan
    • Binding
    • Protein

Connections between topic areas Semantic bridges

For Mecillinam, one of the stronger structural bridges in this analysis connects Mecillinam with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MecillinamOverview · splits 17 ⟂ 13
MecillinamMedical uses · splits 22 ⟂ 8
MecillinamAdverse effects · splits 25 ⟂ 5
MecillinamHistory · splits 27 ⟂ 3

Map overview Semantic statistics

Mecillinam

Nodes30
Edges29
Triples46
Avg. degree1.93
Density0.066667
Components1

Source & methodology

TTTA analyzes the structure around Mecillinam to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Mecillinam · EN edition · Analysis: TopicsToTalkAbout

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