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Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase. Later studies in Ehrlich ascites…
The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around Lonidamine.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around Lonidamine shows recurring relationship patterns in the source. For example, Lonidamine → Interactive image Another extracted example is Lonidamine → L01XX07 (WHO). Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
cells glycolysis inhibit cancer combination derivative aerobic enhance showed anticancer agents brain tumours temozolomide acid normal hexokinase gamendazole indazole-3-carboxylic long
TTTA extracted 13 structured relationships around Lonidamine. Examples in this analysis include Lonidamine → 3D model (JSmol) → Interactive image and Lonidamine → ATC code → L01XX07 (WHO). The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Lonidamine | 3D model (JSmol) | Interactive image | 1.00 | infobox |
| Lonidamine | ATC code | L01XX07 (WHO) | 1.00 | infobox |
| Lonidamine | CAS Number | 50264-69-2 Y | 1.00 | infobox |
| Lonidamine | ChEBI | CHEBI:50138 | 1.00 | infobox |
| Lonidamine | ChemSpider | 36170 N | 1.00 | infobox |
| Lonidamine | CompTox Dashboard (EPA) | DTXSID5020782 | 1.00 | infobox |
| Lonidamine | ECHA InfoCard | 100.051.356 | 1.00 | infobox |
| Lonidamine | Formula | C15H10Cl2N2O2 | 1.00 | infobox |
| Lonidamine | KEGG | D07257 Y | 1.00 | infobox |
| Lonidamine | Molar mass | 321.16 g·mol−1 | 1.00 | infobox |
| Lonidamine | PubChem CID | 39562 | 1.00 | infobox |
| Lonidamine | UNII | U78804BIDR | 1.00 | infobox |
| Lonidamine | is a | derivative of indazole-3-carboxylic acid | 0.90 | text |
The concept neighborhoods around Lonidamine bring nearby vocabulary together. In this analysis, examples include Combination, Brain and Showed. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Bridges highlight paths between different parts of the Lonidamine map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Lonidamine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Lonidamine · EN edition · Analysis: TopicsToTalkAbout