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Lonidamine: Overview, Related Topics & Entities

Lonidamine is a derivative of indazole-3-carboxylic acid, which for a long time, has been known to inhibit aerobic glycolysis in cancer cells. It seems to enhance aerobic glycolysis in normal cells, but suppress glycolysis in cancer cells. This is most likely through the inhibition of the mitochondrially bound hexokinase. Later studies in Ehrlich ascites…

Language: English [EN]
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Lonidamine topic overview

The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around Lonidamine.

Related topics
6
Source areas
1
Connected nodes
7
Extracted relationships
13
Related term clusters
7
Bridge connections
7

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
L01XX07 (WHO)
CAS Number
50264-69-2 Y
ChEBI
CHEBI:50138
ChemSpider
36170 N
CompTox Dashboard (EPA)
DTXSID5020782

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Lonidamine
4Indazole-3-carboxylic acid · Glycolysis · Hexokinase

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Lonidamine connects Entity context

The extracted context around Lonidamine shows recurring relationship patterns in the source. For example, Lonidamine → Interactive image Another extracted example is Lonidamine → L01XX07 (WHO). Use these groups to spot repeated connection types before inspecting the individual relationships.

Lonidamine

Top relations

3D model (JSmol) · 1
Lonidamine → Interactive image
ATC code · 1
Lonidamine → L01XX07 (WHO)
CAS Number · 1
Lonidamine → 50264-69-2 Y
ChEBI · 1
Lonidamine → CHEBI:50138
ChemSpider · 1
Lonidamine → 36170 N
CompTox Dashboard (EPA) · 1
Lonidamine → DTXSID5020782
ECHA InfoCard · 1
Lonidamine → 100.051.356
Formula · 1
Lonidamine → C15H10Cl2N2O2
KEGG · 1
Lonidamine → D07257 Y
Molar mass · 1
Lonidamine → 321.16 g·mol−1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells glycolysis inhibit cancer combination derivative aerobic enhance showed anticancer agents brain tumours temozolomide acid normal hexokinase gamendazole indazole-3-carboxylic long

Lonidamine relationships Subject–Predicate–Object triples

TTTA extracted 13 structured relationships around Lonidamine. Examples in this analysis include Lonidamine → 3D model (JSmol) → Interactive image and Lonidamine → ATC code → L01XX07 (WHO). The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Lonidamine3D model (JSmol)Interactive image1.00infobox
LonidamineATC codeL01XX07 (WHO)1.00infobox
LonidamineCAS Number50264-69-2 Y1.00infobox
LonidamineChEBICHEBI:501381.00infobox
LonidamineChemSpider36170 N1.00infobox
LonidamineCompTox Dashboard (EPA)DTXSID50207821.00infobox
LonidamineECHA InfoCard100.051.3561.00infobox
LonidamineFormulaC15H10Cl2N2O21.00infobox
LonidamineKEGGD07257 Y1.00infobox
LonidamineMolar mass321.16 g·mol−11.00infobox
LonidaminePubChem CID395621.00infobox
LonidamineUNIIU78804BIDR1.00infobox
Lonidamineis aderivative of indazole-3-carboxylic acid0.90text

Related concept clusters Related term clusters

The concept neighborhoods around Lonidamine bring nearby vocabulary together. In this analysis, examples include Combination, Brain and Showed. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Lonidamine
    • Combination
    • Brain
    • Showed
    • Temozolomide
    • Tumours
    • Glycolysis
    • Inhibit
    • Cells
    • Ascites
    • Atp
    • Cellular
    • Decrease
  • lonidamine
    • Combination
    • Brain
    • Showed
    • Temozolomide
    • Tumours
    • Glycolysis
    • Inhibit
    • Cells
    • Ascites
    • Atp
    • Cellular
    • Decrease
  • glycolysis
    • Cells
    • Cancer
    • Ascites
    • Atp
    • Cellular
    • Decrease
    • Ehrlich
    • Indazole-3-carboxylic
    • Inhibits
    • Known
    • Later
    • Leading
  • ehrlich ascites tumor
    • Ascites
    • Atp
    • Cellular
    • Decrease
    • Ehrlich
    • Inhibits
    • Later
    • Leading
    • Respiration
    • Studies
    • Tumor
    • Showed
  • indazole-3-carboxylic acid
    • Known
    • Long
    • Time
    • Acid
    • Aerobic
    • Indazole-3-carboxylic
    • Cancer
    • Derivative
    • Glycolysis
    • Inhibit
    • Normal
    • Lonidamine
  • hexokinase
    • Inhibition
    • Likely
    • Mitochondrially
  • gamendazole
    • Lonidamine

Connections between topic areas Semantic bridges

Bridges highlight paths between different parts of the Lonidamine map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Map overview Semantic statistics

Lonidamine

Nodes8
Edges7
Triples13
Avg. degree1.75
Density0.25
Components1

Source & methodology

TTTA analyzes the structure around Lonidamine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Lonidamine · EN edition · Analysis: TopicsToTalkAbout

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