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LFNG: Products, Function & Impact of mutation

Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe, also known as Lunatic Fringe, is a protein encoded in humans by the LFNG gene.

Language: English [EN]
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LFNG topic overview

The analysis highlights Products, Function and Impact of mutation as prominent areas in the source structure around LFNG.

Related topics
12
Source areas
4
Connected nodes
16
Extracted relationships
93
Related term clusters
11
Bridge connections
16

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 4 topics
Function · 3 topics
Impact of mutation · 3 topics
Clinical significance · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.4.1.222
↗
Aliases
LFNG, SCDO3, LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Band
7p22.3 · 5 G2|5 79.15 cM
Bgee
granulocyte · body of pancreas · monocyte · mucosa of transverse colon · skin of abdomen
BioGPS
More reference expression data
Chr.
Chromosome 7 (human) · Chromosome 5 (mouse)

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Impact of mutation

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How LFNG connects Entity context

The extracted context around LFNG shows recurring relationship patterns in the source. For example, LFNG → acetylglucosaminyltransferase activity, animal organ morphogenesis, compartment pattern specification, extracellular region, extracellular vesicle, glycosyltransferase activity, Golgi apparatus, Golgi membrane, integral component of Golgi membrane, integral component of membrane, marginal zone B cell differentiation, membrane, metal ion binding, molecular function, multicellular organism development, negative regulation of Notch signaling pathway involved in somitogenesis, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity, ovarian follicle development, pattern specification process, positive regulation of meiotic cell cycle Another extracted example is LFNG → blood, body of pancreas, body of stomach, gastrula, granulocyte, lens, lip, lumbar subsegment of spinal cord, mesenteric lymph nodes, minor salivary glands, monocyte, mucosa of transverse colon, nucleus accumbens, skin of abdomen, skin of leg, spleen, tail of embryo, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

LFNG

Top relations

Gene ontology · 28
LFNG → acetylglucosaminyltransferase activity, animal organ morphogenesis, compartment pattern specification, extracellular region, extracellular vesicle, glycosyltransferase activity, Golgi apparatus, Golgi membrane, integral component of Golgi membrane, integral component of membrane, marginal zone B cell differentiation, membrane, metal ion binding, molecular function, multicellular organism development, negative regulation of Notch signaling pathway involved in somitogenesis, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity, ovarian follicle development, pattern specification process, positive regulation of meiotic cell cycle
Bgee · 18
LFNG → blood, body of pancreas, body of stomach, gastrula, granulocyte, lens, lip, lumbar subsegment of spinal cord, mesenteric lymph nodes, minor salivary glands, monocyte, mucosa of transverse colon, nucleus accumbens, skin of abdomen, skin of leg, spleen, tail of embryo, ventricular zone
RNA expression pattern · 18
LFNG → blood, body of pancreas, body of stomach, gastrula, granulocyte, lens, lip, lumbar subsegment of spinal cord, mesenteric lymph nodes, minor salivary glands, monocyte, mucosa of transverse colon, nucleus accumbens, skin of abdomen, skin of leg, spleen, tail of embryo, ventricular zone
related to Clinical significance · 4
LFNG → Clinically, Rather, Respiratory, Spondylocostal
related to Function · 3
LFNG → FGF-8, Hairy, Lunatic Fringe
Band · 2
LFNG → 5 G2|5 79.15 cM, 7p22.3
Chr. · 2
LFNG → Chromosome 5 (mouse), Chromosome 7 (human)
End · 2
LFNG → 140,601,300 bp, 2,529,177 bp
2.4.1.222 · 1
LFNG → ↗
Aliases · 1
LFNG → LFNG, SCDO3, LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene somites mice bp lunatic fringe spondylocostal dysostosis chr human band development glycosyltransferase chromosome signaling protein mutation cell location anterior

LFNG relationships Subject–Predicate–Object triples

TTTA extracted 93 structured relationships around LFNG. Examples in this analysis include LFNG → 2.4.1.222 → ↗ and LFNG → Aliases → LFNG, SCDO3, LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
LFNG2.4.1.222↗1.00infobox
LFNGAliasesLFNG, SCDO3, LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase1.00infobox
LFNGBand7p22.31.00infobox
LFNGBand5 G2|5 79.15 cM1.00infobox
LFNGBgeegranulocyte1.00infobox
LFNGBgeebody of pancreas1.00infobox
LFNGBgeemonocyte1.00infobox
LFNGBgeemucosa of transverse colon1.00infobox
LFNGBgeeskin of abdomen1.00infobox
LFNGBgeeskin of leg1.00infobox
LFNGBgeeventricular zone1.00infobox
LFNGBgeebody of stomach1.00infobox
LFNGBgeeminor salivary glands1.00infobox
LFNGBgeenucleus accumbens1.00infobox
LFNGBgeetail of embryo1.00infobox
LFNGBgeelumbar subsegment of spinal cord1.00infobox
LFNGBgeelip1.00infobox
LFNGBgeemesenteric lymph nodes1.00infobox
LFNGBgeegastrula1.00infobox
LFNGBgeelens1.00infobox
LFNGBgeespleen1.00infobox
LFNGBgeeblood1.00infobox
LFNGBioGPSMore reference expression data1.00infobox
LFNGChr.Chromosome 7 (human)1.00infobox
LFNGChr.Chromosome 5 (mouse)1.00infobox
LFNGDatabasesNCBI: entry; OMA: entry1.00infobox
LFNGEnd2,529,177 bp1.00infobox
LFNGEnd140,601,300 bp1.00infobox
LFNGEnsemblENSG000001060031.00infobox
LFNGEntrez39551.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around LFNG bring nearby vocabulary together. In this analysis, examples include Mice, Function and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • somites
    • Role
    • Anterior
    • Signaling
    • Fringe
    • Lunatic
    • Cell
    • Fgf8
    • Leads
    • Development
    • Gene
    • Function
    • Golgi
  • LFNG
    • Mice
    • Function
    • Gene
    • Associated
    • Female
    • Location
    • Protein
    • Chromosome
    • Development
    • Human
    • Bp
    • Chr
  • lfng
    • Mice
    • Function
    • Gene
    • Associated
    • Female
    • Location
    • Protein
    • Chromosome
    • Development
    • Human
    • Bp
    • Chr
  • function
    • Location
    • Chromosome
    • External
    • Human
    • Bp
    • Chr
    • Golgi
    • Involved
    • Membrane
    • Mouse
    • Gene
    • Glycosyltransferase
  • glycosyltransferase
    • Golgi
    • Involved
    • Membrane
    • Protein
    • Signaling
    • Fate
    • Function
    • Mouse
    • Location
    • Role
    • Anterior
    • Band
  • spondylocostal dysostosis 3
    • Dysostosis
    • Spondylocostal
    • Autosomal
    • Mutations
    • Associated
    • Gene
    • Also
    • Mutation
    • Fringe
    • Lunatic
    • Lfng
  • spondylocostal dysostosis
    • Dysostosis
    • Spondylocostal
    • Autosomal
    • Mutations
    • Associated
    • Gene
    • Also
    • Mutation
    • Fringe
    • Lunatic
    • Lfng
  • fgf8
    • Leads
    • Somites
    • Model
    • Signaling
    • Fringe
    • Lunatic

Connections between topic areas Semantic bridges

For LFNG, one of the stronger structural bridges in this analysis connects LFNG with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
LFNG — Overview · splits 12 ⟂ 5
LFNG — Function · splits 13 ⟂ 4
LFNG — Impact of mutation · splits 13 ⟂ 4
LFNG — Clinical significance · splits 14 ⟂ 3

Map overview Semantic statistics

LFNG

Nodes17
Edges16
Triples93
Avg. degree1.88
Density0.117647
Components1

Source & methodology

TTTA analyzes the structure around LFNG to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Products, Function & Impact of mutation, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — LFNG · EN edition · Analysis: TopicsToTalkAbout

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