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Izumo sperm-egg fusion protein 1 (Sperm-specific protein izumo) is encoded in humans by the IZUMO1 gene. In mammalian fertilisation, IZUMO1 binds to its egg receptor counterpart, Juno, to facilitate recognition and fusion of the gametes.
The analysis highlights Art, Function and Overview as prominent areas in the source structure around IZUMO1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around IZUMO1 shows recurring relationship patterns in the source. For example, IZUMO1 → apex of heart, blastocyst, body of pancreas, body of stomach, embryo, epiblast, esophagus, left testis, lip, right adrenal cortex, right hemisphere of cerebellum, right lung, right testis, seminiferous tubule, sperm, spermatid, spermatocyte, upper lobe of left lung, yolk sac Another extracted example is IZUMO1 → acrosomal membrane, cell adhesion, cytoplasmic vesicle, fusion of sperm to egg plasma membrane involved in single fertilization, heterotypic cell-cell adhesion, identical protein binding, integral component of membrane, membrane, plasma membrane, protein binding, protein binding involved in heterotypic cell-cell adhesion, protein homodimerization activity, signaling receptor binding, single fertilization, sperm-egg recognition. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
fusion bp human izumo chr band gene sperm-egg chromosome 19 protein receptor location membrane mouse egg recognition juno function sperm-specific
TTTA extracted 82 structured relationships around IZUMO1. Examples in this analysis include IZUMO1 → Aliases → IZUMO1, IZUMO, OBF, izumo sperm-egg fusion 1 and IZUMO1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5JKD, 5F4T, 5JKC, 5JK9, 5JKE, 5F4V, 5F4E. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| IZUMO1 | Aliases | IZUMO1, IZUMO, OBF, izumo sperm-egg fusion 1 | 1.00 | infobox |
| IZUMO1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5JKD, 5F4T, 5JKC, 5JK9, 5JKE, 5F4V, 5F4E | 1.00 | infobox |
| IZUMO1 | Band | 19q13.33 | 1.00 | infobox |
| IZUMO1 | Band | 7|7 B3 | 1.00 | infobox |
| IZUMO1 | Bgee | right testis | 1.00 | infobox |
| IZUMO1 | Bgee | left testis | 1.00 | infobox |
| IZUMO1 | Bgee | sperm | 1.00 | infobox |
| IZUMO1 | Bgee | body of pancreas | 1.00 | infobox |
| IZUMO1 | Bgee | upper lobe of left lung | 1.00 | infobox |
| IZUMO1 | Bgee | right hemisphere of cerebellum | 1.00 | infobox |
| IZUMO1 | Bgee | body of stomach | 1.00 | infobox |
| IZUMO1 | Bgee | right adrenal cortex | 1.00 | infobox |
| IZUMO1 | Bgee | right lung | 1.00 | infobox |
| IZUMO1 | Bgee | apex of heart | 1.00 | infobox |
| IZUMO1 | Bgee | spermatid | 1.00 | infobox |
| IZUMO1 | Bgee | seminiferous tubule | 1.00 | infobox |
| IZUMO1 | Bgee | spermatocyte | 1.00 | infobox |
| IZUMO1 | Bgee | embryo | 1.00 | infobox |
| IZUMO1 | Bgee | blastocyst | 1.00 | infobox |
| IZUMO1 | Bgee | yolk sac | 1.00 | infobox |
| IZUMO1 | Bgee | epiblast | 1.00 | infobox |
| IZUMO1 | Bgee | lip | 1.00 | infobox |
| IZUMO1 | Bgee | esophagus | 1.00 | infobox |
| IZUMO1 | BioGPS | n/a | 1.00 | infobox |
| IZUMO1 | Chr. | Chromosome 19 (human) | 1.00 | infobox |
| IZUMO1 | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| IZUMO1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| IZUMO1 | End | 48,746,909 bp | 1.00 | infobox |
| IZUMO1 | End | 45,628,823 bp | 1.00 | infobox |
| IZUMO1 | Ensembl | ENSG00000182264 | 1.00 | infobox |
The concept neighborhoods around IZUMO1 bring nearby vocabulary together. In this analysis, examples include Sperm-egg, Egg and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For IZUMO1, one of the stronger structural bridges in this analysis connects IZUMO1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around IZUMO1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — IZUMO1 · EN edition · Analysis: TopicsToTalkAbout