Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

IGSF1: Function, Animal model & Clinical relevance

Immunoglobulin superfamily, member 1 is a plasma membrane glycoprotein encoded by the IGSF1 gene, which maps to the X chromosome in humans and other mammalian species.

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

IGSF1 topic overview

The analysis highlights Function, Animal model and Clinical relevance as prominent areas in the source structure around IGSF1.

Related topics
16
Source areas
4
Connected nodes
20
Extracted relationships
99
Concept neighborhoods
13
Bridge connections
20

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 6 topics
Animal model · 5 topics
Overview · 3 topics
Clinical relevance · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
IGSF1, CHTE, IGCD1, IGDC1, INHBP, PGSF2, p120, immunoglobulin superfamily member 1
Band
Xq26.1 · X|X A5
Bgee
pituitary gland · anterior pituitary · right auricle of heart · hypothalamus · tibial nerve
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical relevance

Animal model

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How IGSF1 connects Entity context

The extracted context around IGSF1 shows recurring relationship patterns in the source. For example, IGSF1 → anterior pituitary, apex of heart, arcuate nucleus, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, hypothalamus, lateral hypothalamus, left testis, lumbar subsegment of spinal cord, mammillary body, median eminence, nucleus accumbens, pituitary gland, right auricle of heart, right testis, substantia nigra, suprachiasmatic nucleus, tibial nerve, ventral tegmental area, ventromedial nucleus Another extracted example is IGSF1 → CTD, ER, However, Ig, IGSF1's, It, NTD, Only, Pathogenic, The, The NTD. Use these groups to spot repeated connection types before inspecting the individual relationships.

IGSF1

Top relations

Bgee · 20
IGSF1 → anterior pituitary, apex of heart, arcuate nucleus, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, hypothalamus, lateral hypothalamus, left testis, lumbar subsegment of spinal cord, mammillary body, median eminence, nucleus accumbens, pituitary gland, right auricle of heart, right testis, substantia nigra, suprachiasmatic nucleus, tibial nerve, ventral tegmental area, ventromedial nucleus
RNA expression pattern · 20
IGSF1 → anterior pituitary, apex of heart, arcuate nucleus, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, hypothalamus, lateral hypothalamus, left testis, lumbar subsegment of spinal cord, mammillary body, median eminence, nucleus accumbens, pituitary gland, right auricle of heart, right testis, substantia nigra, suprachiasmatic nucleus, tibial nerve, ventral tegmental area, ventromedial nucleus
related to Function · 11
IGSF1 → CTD, ER, However, Ig, IGSF1's, It, NTD, Only, Pathogenic, The, The NTD
Gene ontology · 10
IGSF1 → activin receptor antagonist activity, coreceptor activity, extracellular region, inhibin binding, integral component of membrane, membrane, negative regulation of activin receptor signaling pathway, protein binding, regulation of transcription, DNA-templated, signal transduction
related to Animal model · 8
IGSF1 → How, In Igsf1, Mice, The, The IGSF1, This, TRH, TSH
related to Clinical relevance · 8
IGSF1 → CHTE, It, Males, Most, Mutations, Post-pubertally, The, The IGSF1
Band · 2
IGSF1 → Xq26.1, X|X A5
Chr. · 2
IGSF1 → X chromosome (human), X chromosome (mouse)
End · 2
IGSF1 → 131,578,899 bp, 48,886,626 bp
causes · 2
IGSF1 → a condition called IGSF1 deficiency syndrome or central hypothyroidism/testicular enlargement, a decrease in TRH receptors is presently unknown

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp chromosome chr human band hypothyroidism membrane pituitary immunoglobulin superfamily member location function protein plasma mouse gland species ctd

IGSF1 relationships Subject–Predicate–Object triples

TTTA extracted 99 structured relationships around IGSF1. Examples in this analysis include IGSF1 → Aliases → IGSF1, CHTE, IGCD1, IGDC1, INHBP, PGSF2, p120, immunoglobulin superfamily member 1 and IGSF1 → Band → Xq26.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
IGSF1AliasesIGSF1, CHTE, IGCD1, IGDC1, INHBP, PGSF2, p120, immunoglobulin superfamily member 11.00infobox
IGSF1BandXq26.11.00infobox
IGSF1BandX|X A51.00infobox
IGSF1Bgeepituitary gland1.00infobox
IGSF1Bgeeanterior pituitary1.00infobox
IGSF1Bgeeright auricle of heart1.00infobox
IGSF1Bgeehypothalamus1.00infobox
IGSF1Bgeetibial nerve1.00infobox
IGSF1Bgeenucleus accumbens1.00infobox
IGSF1Bgeeapex of heart1.00infobox
IGSF1Bgeeleft testis1.00infobox
IGSF1Bgeeright testis1.00infobox
IGSF1Bgeesubstantia nigra1.00infobox
IGSF1Bgeearcuate nucleus1.00infobox
IGSF1Bgeemedian eminence1.00infobox
IGSF1Bgeedorsomedial hypothalamic nucleus1.00infobox
IGSF1Bgeeventromedial nucleus1.00infobox
IGSF1Bgeesuprachiasmatic nucleus1.00infobox
IGSF1Bgeedorsal tegmental nucleus1.00infobox
IGSF1Bgeemammillary body1.00infobox
IGSF1Bgeelateral hypothalamus1.00infobox
IGSF1Bgeelumbar subsegment of spinal cord1.00infobox
IGSF1Bgeeventral tegmental area1.00infobox
IGSF1BioGPSMore reference expression data1.00infobox
IGSF1Chr.X chromosome (human)1.00infobox
IGSF1Chr.X chromosome (mouse)1.00infobox
IGSF1DatabasesNCBI: entry; OMA: entry1.00infobox
IGSF1End131,578,899 bp1.00infobox
IGSF1End48,886,626 bp1.00infobox
IGSF1EnsemblENSG000001472551.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around IGSF1 bring nearby vocabulary together. In this analysis, examples include Gene, Central and Deficiency. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • IGSF1
    • Gene
    • Central
    • Deficiency
    • Mice
    • Membrane
    • Pituitary
    • Chromosome
    • Hypothyroidism
    • Chte
    • Function
    • Humans
    • Receptor
  • igsf1
    • Gene
    • Central
    • Deficiency
    • Mice
    • Membrane
    • Pituitary
    • Chromosome
    • Hypothyroidism
    • Chte
    • Function
    • Humans
    • Receptor
  • gene
    • Igsf1
    • Chromosome
    • Location
    • Human
    • Membrane
    • Bp
    • Chr
    • End
    • Function
    • Mouse
    • Species
    • Gland
  • x chromosome
    • Human
    • Bp
    • Chr
    • Location
    • Band
    • Gene
    • End
    • Function
    • Mouse
    • Species
    • Immunoglobulin
    • Member
  • function
    • Location
    • Human
    • Bp
    • Chr
    • Chte
    • End
    • Hypothalamus
    • Mouse
    • Receptor
    • Species
    • Gene
    • Gland
  • immunoglobulin (ig) superfamily
    • Immunoglobulin
    • Member
    • Superfamily
    • Chromosome
    • Chte
    • Function
    • Humans
    • Ig
    • Protein
    • Species
    • Gene
    • Location
  • plasma membrane
    • Membrane
    • Plasma
    • Ctd
    • Species
    • End
    • Function
    • Hypothalamus
    • Mouse
    • Receptor
    • Superfamily
    • Gland
    • Location
  • pituitary gland
    • Receptor
    • Pituitary
    • Hypothalamus
    • Mouse
    • Species
    • Location
    • Protein
    • Tsh
    • Hormone
    • Human
    • Membrane
    • Mice

Connections between topic areas Semantic bridges

For IGSF1, one of the stronger structural bridges in this analysis connects IGSF1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
IGSF1Function · splits 14 ⟂ 7
IGSF1Animal model · splits 15 ⟂ 6
IGSF1Overview · splits 17 ⟂ 4
IGSF1Clinical relevance · splits 18 ⟂ 3

Map overview Semantic statistics

IGSF1

Nodes21
Edges20
Triples99
Avg. degree1.9
Density0.095238
Components1

Source & methodology

TTTA analyzes the structure around IGSF1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Animal model & Clinical relevance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — IGSF1 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.