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IGSF1

Immunoglobulin superfamily, member 1 is a plasma membrane glycoprotein encoded by the IGSF1 gene, which maps to the X chromosome in humans and other mammalian species.

[EN, English, English]

Function, Animal model & Clinical relevance

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Explore the main themes, entities and connections around IGSF1. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
IGSF1, CHTE, IGCD1, IGDC1, INHBP, PGSF2, p120, immunoglobulin superfamily member 1
Band
Xq26.1 · X|X A5
Bgee
pituitary gland · anterior pituitary · right auricle of heart · hypothalamus · tibial nerve
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)
Databases
NCBI: entry; OMA: entry

Topics to explore

A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.

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Overview

Function

Clinical relevance

Animal model

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.

IGSF1

Nodes21
Edges20
Triples99
Avg. degree1.9
Density0.095238
Components1

How this topic connects Entity context

Quick relationship hints grouped by predicate. Useful for spotting recurring semantic connections around the current entity.

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IGSF1

Top relations

Bgee · 20
IGSF1 → anterior pituitary, apex of heart, arcuate nucleus, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, hypothalamus, lateral hypothalamus, left testis, lumbar subsegment of spinal cord, mammillary body, median eminence, nucleus accumbens, pituitary gland, right auricle of heart, right testis, substantia nigra, suprachiasmatic nucleus, tibial nerve, ventral tegmental area, ventromedial nucleus
RNA expression pattern · 20
IGSF1 → anterior pituitary, apex of heart, arcuate nucleus, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, hypothalamus, lateral hypothalamus, left testis, lumbar subsegment of spinal cord, mammillary body, median eminence, nucleus accumbens, pituitary gland, right auricle of heart, right testis, substantia nigra, suprachiasmatic nucleus, tibial nerve, ventral tegmental area, ventromedial nucleus
related to Function · 11
IGSF1 → CTD, ER, However, Ig, IGSF1's, It, NTD, Only, Pathogenic, The, The NTD
Gene ontology · 10
IGSF1 → activin receptor antagonist activity, coreceptor activity, extracellular region, inhibin binding, integral component of membrane, membrane, negative regulation of activin receptor signaling pathway, protein binding, regulation of transcription, DNA-templated, signal transduction
related to Animal model · 8
IGSF1 → How, In Igsf1, Mice, The, The IGSF1, This, TRH, TSH
related to Clinical relevance · 8
IGSF1 → CHTE, It, Males, Most, Mutations, Post-pubertally, The, The IGSF1
Band · 2
IGSF1 → Xq26.1, X|X A5
Chr. · 2
IGSF1 → X chromosome (human), X chromosome (mouse)
End · 2
IGSF1 → 131,578,899 bp, 48,886,626 bp
causes · 2
IGSF1 → a condition called IGSF1 deficiency syndrome or central hypothyroidism/testicular enlargement, a decrease in TRH receptors is presently unknown

Important terminology Word statistics

Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.

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Important terminology

gene bp chromosome chr human band hypothyroidism membrane pituitary immunoglobulin superfamily member location function protein plasma mouse gland species ctd

Entity relationships Subject–Predicate–Object triples

Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.
SubjectPredicateObjectConfidenceSrc
IGSF1AliasesIGSF1, CHTE, IGCD1, IGDC1, INHBP, PGSF2, p120, immunoglobulin superfamily member 11.00infobox
IGSF1BandXq26.11.00infobox
IGSF1BandX|X A51.00infobox
IGSF1Bgeepituitary gland1.00infobox
IGSF1Bgeeanterior pituitary1.00infobox
IGSF1Bgeeright auricle of heart1.00infobox
IGSF1Bgeehypothalamus1.00infobox
IGSF1Bgeetibial nerve1.00infobox
IGSF1Bgeenucleus accumbens1.00infobox
IGSF1Bgeeapex of heart1.00infobox
IGSF1Bgeeleft testis1.00infobox
IGSF1Bgeeright testis1.00infobox
IGSF1Bgeesubstantia nigra1.00infobox
IGSF1Bgeearcuate nucleus1.00infobox
IGSF1Bgeemedian eminence1.00infobox
IGSF1Bgeedorsomedial hypothalamic nucleus1.00infobox
IGSF1Bgeeventromedial nucleus1.00infobox
IGSF1Bgeesuprachiasmatic nucleus1.00infobox
IGSF1Bgeedorsal tegmental nucleus1.00infobox
IGSF1Bgeemammillary body1.00infobox
IGSF1Bgeelateral hypothalamus1.00infobox
IGSF1Bgeelumbar subsegment of spinal cord1.00infobox
IGSF1Bgeeventral tegmental area1.00infobox
IGSF1BioGPSMore reference expression data1.00infobox
IGSF1Chr.X chromosome (human)1.00infobox
IGSF1Chr.X chromosome (mouse)1.00infobox
IGSF1DatabasesNCBI: entry; OMA: entry1.00infobox
IGSF1End131,578,899 bp1.00infobox
IGSF1End48,886,626 bp1.00infobox
IGSF1EnsemblENSG000001472551.00infobox

Related concept clusters Concept neighborhoods

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