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HATU

HATU (Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium) is a reagent used in peptide coupling chemistry to generate an active ester from a carboxylic acid. HATU is used along with Hünig's base (N,N-diisopropylethylamine), or triethylamine to form amide bonds. Typically dimethylformamide is used as solvent, although other polar aprotic solvents…

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Overview

History

Reactions

Safety

Advanced semantic analysis

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Map overview Semantic statistics

HATU

Nodes22
Edges21
Triples32
Avg. degree1.91
Density0.090909
Components1

How this topic connects Entity context

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HATU

Top relations

related to Safety · 13
HATU → Chemicals, Classification, Dermal Sensitization Category, Differential, DSC, GHS, Globally Harmonized System, In, Labelling, LLNA, Local Lymph Node Assay, OECD, Thermal
related to history · 10
HATU → Carpino, HOAt, It, KOAt, Louis, N-form, NMR, O-form, TCFH, X-ray
related to Reactions · 8
HATU → Addition, In, N-acylation, O-acyl, OAt-active, Such, The, The OAt
is a · 1
HATU → moderate skin sensitizer

Important terminology Word statistics

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Important terminology

used reaction amine uronium ester carboxylic acid form reactions coupling active state hexafluorophosphate references reported hoat commonly salt using however

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
HATUis amoderate skin sensitizer0.90text
HATUrelated to historyLouis0.60section
HATUrelated to historyCarpino0.60section
HATUrelated to historyHOAt0.60section
HATUrelated to historyTCFH0.60section
HATUrelated to historyO-form0.60section
HATUrelated to historyN-form0.60section
HATUrelated to historyX-ray0.60section
HATUrelated to historyNMR0.60section
HATUrelated to historyIt0.60section
HATUrelated to historyKOAt0.60section
HATUrelated to ReactionsSuch0.60section

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