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H-89

H-89 is a protein kinase inhibitor with greatest effect on protein kinase A (PKA). H-89, derived from H-8 (N-[2-(methylamino)ethyl]-5-isoquinoline-sulfonamide), was initially believed to act specifically as an inhibitor of PKA, being 30 times more potent than H-8 at inhibiting PKA and 10 times less potent at inhibiting protein kinase G. It achieves this…

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H-89

Nodes14
Edges13
Triples2
Avg. degree1.86
Density0.142857
Components1

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H-89

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H-89 → protein kinase inhibitor with greatest effect on protein kinase A

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Important terminology

pka protein kinase inhibitor inhibition n- 2- ethyl references standard state ic50 s6k1 msk1 rockii pkbα mapkap-k1b greatest effect derived

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
H-89is aprotein kinase inhibitor with greatest effect on protein kinase A0.90text
inhibition of other protein kinasesinstance ofsubsequent work has suggested a variety of additional effects0.80text

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