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GJA5: Related gene problems, Function & Overview

Gap junction alpha-5 protein (GJA5), also known as connexin 40 (Cx40) — is a protein that in humans is encoded by the GJA5 gene.

Language: English [EN]
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GJA5 topic overview

The analysis highlights Related gene problems, Function and Overview as prominent areas in the source structure around GJA5.

Related topics
5
Source areas
3
Connected nodes
8
Extracted relationships
141
Concept neighborhoods
9
Bridge connections
8

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 2 topics
Related gene problems · 2 topics
Function · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
GJA5, ATFB11, CX40, gap junction protein alpha 5
Band
1q21.2 · 3 F2.1|3 42.04 cM
Bgee
placenta · right coronary artery · left coronary artery · right auricle of heart · lower lobe of lung
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 3 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Related gene problems

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How GJA5 connects Entity context

The extracted context around GJA5 shows recurring relationship patterns in the source. For example, GJA5 → angiogenesis, artery morphogenesis, atrial cardiac muscle cell to AV node cell communication by electrical coupling, atrial septum development, atrial septum morphogenesis, atrial ventricular junction remodeling, AV node cell to bundle of His cell communication, AV node cell to bundle of His cell communication by electrical coupling, blood vessel development, blood vessel diameter maintenance, bundle of His cell to Purkinje myocyte communication by electrical coupling, cardiac conduction, cardiac conduction system development, cell communication, cell communication by chemical coupling, cell communication by electrical coupling, cell communication by electrical coupling involved in cardiac conduction, cell communication involved in cardiac conduction, cell junction, cell projection Another extracted example is GJA5 → abdominal aorta, atrium, Descending thoracic aorta, dorsal aorta, footplate, left coronary artery, lower lobe of lung, myocardium of atrium, placenta, popliteal artery, primordial ventricle, right auricle of heart, right coronary artery, tibial arteries, tongue muscle, upper lobe of left lung, upper lobe of lung, vascular endothelium, vasculature of trunk, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

GJA5

Top relations

Gene ontology · 75
GJA5 → angiogenesis, artery morphogenesis, atrial cardiac muscle cell to AV node cell communication by electrical coupling, atrial septum development, atrial septum morphogenesis, atrial ventricular junction remodeling, AV node cell to bundle of His cell communication, AV node cell to bundle of His cell communication by electrical coupling, blood vessel development, blood vessel diameter maintenance, bundle of His cell to Purkinje myocyte communication by electrical coupling, cardiac conduction, cardiac conduction system development, cell communication, cell communication by chemical coupling, cell communication by electrical coupling, cell communication by electrical coupling involved in cardiac conduction, cell communication involved in cardiac conduction, cell junction, cell projection
Bgee · 20
GJA5 → abdominal aorta, atrium, Descending thoracic aorta, dorsal aorta, footplate, left coronary artery, lower lobe of lung, myocardium of atrium, placenta, popliteal artery, primordial ventricle, right auricle of heart, right coronary artery, tibial arteries, tongue muscle, upper lobe of left lung, upper lobe of lung, vascular endothelium, vasculature of trunk, yolk sac
RNA expression pattern · 20
GJA5 → abdominal aorta, atrium, Descending thoracic aorta, dorsal aorta, footplate, left coronary artery, lower lobe of lung, myocardium of atrium, placenta, popliteal artery, primordial ventricle, right auricle of heart, right coronary artery, tibial arteries, tongue muscle, upper lobe of left lung, upper lobe of lung, vascular endothelium, vasculature of trunk, yolk sac
related to Function · 6
GJA5 → Alternatively, Fallot, In, Mutations, The, This
Band · 2
GJA5 → 1q21.2, 3 F2.1|3 42.04 cM
Chr. · 2
GJA5 → Chromosome 1 (human), Chromosome 3 (mouse)
End · 2
GJA5 → 147,773,362 bp, 96,984,732 bp
Aliases · 1
GJA5 → GJA5, ATFB11, CX40, gap junction protein alpha 5
BioGPS · 1
GJA5 → More reference expression data
Databases · 1
GJA5 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp chr human band gap connexin protein junction chromosome location also mouse 1q21 heart cx40 function encoded 773 362

GJA5 relationships Subject–Predicate–Object triples

TTTA extracted 141 structured relationships around GJA5. Examples in this analysis include GJA5 → Aliases → GJA5, ATFB11, CX40, gap junction protein alpha 5 and GJA5 → Band → 1q21.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
GJA5AliasesGJA5, ATFB11, CX40, gap junction protein alpha 51.00infobox
GJA5Band1q21.21.00infobox
GJA5Band3 F2.1|3 42.04 cM1.00infobox
GJA5Bgeeplacenta1.00infobox
GJA5Bgeeright coronary artery1.00infobox
GJA5Bgeeleft coronary artery1.00infobox
GJA5Bgeeright auricle of heart1.00infobox
GJA5Bgeelower lobe of lung1.00infobox
GJA5Bgeepopliteal artery1.00infobox
GJA5Bgeetibial arteries1.00infobox
GJA5Bgeeupper lobe of lung1.00infobox
GJA5BgeeDescending thoracic aorta1.00infobox
GJA5Bgeeupper lobe of left lung1.00infobox
GJA5Bgeeyolk sac1.00infobox
GJA5Bgeevascular endothelium1.00infobox
GJA5Bgeevasculature of trunk1.00infobox
GJA5Bgeefootplate1.00infobox
GJA5Bgeedorsal aorta1.00infobox
GJA5Bgeeatrium1.00infobox
GJA5Bgeeprimordial ventricle1.00infobox
GJA5Bgeetongue muscle1.00infobox
GJA5Bgeemyocardium of atrium1.00infobox
GJA5Bgeeabdominal aorta1.00infobox
GJA5BioGPSMore reference expression data1.00infobox
GJA5Chr.Chromosome 1 (human)1.00infobox
GJA5Chr.Chromosome 3 (mouse)1.00infobox
GJA5DatabasesNCBI: entry; OMA: entry1.00infobox
GJA5End147,773,362 bp1.00infobox
GJA5End96,984,732 bp1.00infobox
GJA5EnsemblENSG000002651071.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around GJA5 bring nearby vocabulary together. In this analysis, examples include Gene, Junction and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • GJA5
    • Gene
    • Junction
    • Location
    • Protein
    • Function
    • Heart
    • Chromosome
    • Human
    • Bp
    • Chr
    • Atrial
    • Case
  • gja5
    • Gene
    • Junction
    • Location
    • Protein
    • Function
    • Heart
    • Chromosome
    • Human
    • Bp
    • Chr
    • Atrial
    • Case
  • protein
    • Gap
    • Junction
    • Also
    • Cell
    • Component
    • Cx40
    • Encoded
    • Function
    • Gja5
    • Molecular
    • Gene
    • Connexin
  • 1q21.1 duplication syndrome
    • Location
    • Common
    • Deletion
    • Fallot
    • Tetralogy
    • Gene
    • Congenital
    • Diseases
    • Duplication
    • End
    • F2
    • Mouse
  • gene
    • Location
    • Gja5
    • Chromosome
    • Human
    • Junction
    • Protein
    • Bp
    • Chr
    • Atrial
    • End
    • F2
    • Function
  • 1q21.1 deletion syndrome
    • Location
    • Diseases
    • Duplication
    • Fallot
    • Tetralogy
    • Gene
    • Congenital
    • Deletion
    • End
    • F2
    • Heart
    • Mouse
  • related gene problems
    • Location
    • Gja5
    • Chromosome
    • Human
    • Junction
    • Protein
    • Bp
    • Chr
    • Atrial
    • End
    • F2
    • Function
  • function
    • Chromosome
    • Human
    • Junction
    • Location
    • Protein
    • Bp
    • Chr
    • Gap
    • Gja5
    • Atrial
    • Cell
    • Component

Connections between topic areas Semantic bridges

For GJA5, one of the stronger structural bridges in this analysis connects GJA5 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
GJA5Overview · splits 6 ⟂ 3
GJA5Related gene problems · splits 6 ⟂ 3

Map overview Semantic statistics

GJA5

Nodes9
Edges8
Triples141
Avg. degree1.78
Density0.222222
Components1

Source & methodology

TTTA analyzes the structure around GJA5 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Related gene problems, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — GJA5 · EN edition · Analysis: TopicsToTalkAbout

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