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Growth/differentiation factor 5 is a protein that in humans is encoded by the GDF5 gene.
The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around GDF5.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around GDF5 shows recurring relationship patterns in the source. For example, GDF5 → BMP binding, BMP signaling pathway, cartilage development, cell development, cell-cell signaling, chondroblast differentiation, chondrocyte differentiation, cytokine activity, embryonic limb morphogenesis, extracellular region, extracellular space, forelimb morphogenesis, growth factor activity, hindlimb morphogenesis, identical protein binding, membrane, negative regulation of chondrocyte differentiation, negative regulation of epithelial cell proliferation, negative regulation of mesenchymal cell apoptotic process, negative regulation of neuron apoptotic process Another extracted example is GDF5 → annulus fibrosus disci intervertebralis, cartilage tissue, cuneiform bones, elbow, finger, hand joint, interphalangeal joint of hand, joints of the foot, lacrimal gland, minor salivary glands, molar, oral mucosa, parotid gland, pericardium, pharynx, sensory nervous system, synovial joint, synovial membrane, upper respiratory tract. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene bp protein chr human band growth differentiation chromosome 20 development factor location encoded family associated role skeletal also mouse
TTTA extracted 99 structured relationships around GDF5. Examples in this analysis include GDF5 → Aliases → GDF5, BDA1C, BMP-14, BMP14, CDMP1, LAP-4, LAP4, OS5, SYM1B, SYNS2, growth differentiation factor 5, DUPANS and GDF5 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1WAQ, 2BHK, 3EVS, 3QB4. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| GDF5 | Aliases | GDF5, BDA1C, BMP-14, BMP14, CDMP1, LAP-4, LAP4, OS5, SYM1B, SYNS2, growth differentiation factor 5, DUPANS | 1.00 | infobox |
| GDF5 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1WAQ, 2BHK, 3EVS, 3QB4 | 1.00 | infobox |
| GDF5 | Band | 20q11.22 | 1.00 | infobox |
| GDF5 | Band | 2 H1|2 77.26 cM | 1.00 | infobox |
| GDF5 | Bgee | parotid gland | 1.00 | infobox |
| GDF5 | Bgee | pericardium | 1.00 | infobox |
| GDF5 | Bgee | cartilage tissue | 1.00 | infobox |
| GDF5 | Bgee | synovial joint | 1.00 | infobox |
| GDF5 | Bgee | synovial membrane | 1.00 | infobox |
| GDF5 | Bgee | oral mucosa | 1.00 | infobox |
| GDF5 | Bgee | minor salivary glands | 1.00 | infobox |
| GDF5 | Bgee | sensory nervous system | 1.00 | infobox |
| GDF5 | Bgee | pharynx | 1.00 | infobox |
| GDF5 | Bgee | upper respiratory tract | 1.00 | infobox |
| GDF5 | Bgee | finger | 1.00 | infobox |
| GDF5 | Bgee | elbow | 1.00 | infobox |
| GDF5 | Bgee | hand joint | 1.00 | infobox |
| GDF5 | Bgee | joints of the foot | 1.00 | infobox |
| GDF5 | Bgee | lacrimal gland | 1.00 | infobox |
| GDF5 | Bgee | interphalangeal joint of hand | 1.00 | infobox |
| GDF5 | Bgee | annulus fibrosus disci intervertebralis | 1.00 | infobox |
| GDF5 | Bgee | molar | 1.00 | infobox |
| GDF5 | Bgee | cuneiform bones | 1.00 | infobox |
| GDF5 | BioGPS | More reference expression data | 1.00 | infobox |
| GDF5 | Chr. | Chromosome 20 (human) | 1.00 | infobox |
| GDF5 | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| GDF5 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| GDF5 | End | 35,454,746 bp | 1.00 | infobox |
| GDF5 | End | 155,787,287 bp | 1.00 | infobox |
| GDF5 | Ensembl | ENSG00000125965 | 1.00 | infobox |
The concept neighborhoods around GDF5 bring nearby vocabulary together. In this analysis, examples include Growth, Expressed and Joint. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Bridges highlight paths between different parts of the GDF5 map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around GDF5 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — GDF5 · EN edition · Analysis: TopicsToTalkAbout