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Gamma-butyrobetaine dioxygenase: Reaction, Inhibition & Assay

Gamma-butyrobetaine dioxygenase (also known as BBOX, GBBH or γ-butyrobetaine hydroxylase) is an enzyme that in humans is encoded by the BBOX1 gene. Gamma-butyrobetaine dioxygenase catalyses the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthesis pathway. Carnitine is essential for the transport of activated…

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Gamma-butyrobetaine dioxygenase topic overview

The analysis highlights Reaction, Inhibition and Assay as prominent areas in the source structure around Gamma-butyrobetaine dioxygenase.

Related topics
66
Source areas
4
Connected nodes
70
Extracted relationships
113
Concept neighborhoods
22
Bridge connections
70

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Reaction · 21 topics
Inhibition · 19 topics
Assay · 16 topics
Overview · 10 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.14.11.1
↗
Aliases
BBOX1, BBH, BBOX, G-BBH, gamma-BBH, gamma-butyrobetaine hydroxylase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3MS5, 3N6W, 3O2G, 4BG1, 4BGK, 4BGM, 4BHF, 4BHG, 4BHI, 4C5W, 4C8R, 4CWD
Band
11p14.2 · 2|2 E3
Bgee
kidney tubule · glomerulus · human kidney · gingival epithelium · metanephric glomerulus
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Reaction

Inhibition

Assay

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Gamma-butyrobetaine dioxygenase connects Entity context

The extracted context around Gamma-butyrobetaine dioxygenase shows recurring relationship patterns in the source. For example, Gamma-butyrobetaine dioxygenase → deep cerebellar nuclei, epidermis, external globus pallidus, gingival epithelium, glomerulus, hair follicle, human kidney, kidney tubule, left lobe of liver, lip, lumbar subsegment of spinal cord, metanephric glomerulus, renal medulla, skin of arm, skin of back, skin of external ear, skin of hip, skin of thigh, substantia nigra, vestibular membrane of cochlear duct Another extracted example is Gamma-butyrobetaine dioxygenase → Although, C-4, CH2, Gamma-butyrobetaine, Grindeks, However, Latvia, Meldonium, MET-88, Mildronate, NH, PDB, Quarterine, Some, THP, To. Use these groups to spot repeated connection types before inspecting the individual relationships.

Gamma-butyrobetaine dioxygenase

Top relations

Bgee · 20
Gamma-butyrobetaine dioxygenase → deep cerebellar nuclei, epidermis, external globus pallidus, gingival epithelium, glomerulus, hair follicle, human kidney, kidney tubule, left lobe of liver, lip, lumbar subsegment of spinal cord, metanephric glomerulus, renal medulla, skin of arm, skin of back, skin of external ear, skin of hip, skin of thigh, substantia nigra, vestibular membrane of cochlear duct
RNA expression pattern · 20
Gamma-butyrobetaine dioxygenase → deep cerebellar nuclei, epidermis, external globus pallidus, gingival epithelium, glomerulus, hair follicle, human kidney, kidney tubule, left lobe of liver, lip, lumbar subsegment of spinal cord, metanephric glomerulus, renal medulla, skin of arm, skin of back, skin of external ear, skin of hip, skin of thigh, substantia nigra, vestibular membrane of cochlear duct
related to Inhibition · 16
Gamma-butyrobetaine dioxygenase → Although, C-4, CH2, Gamma-butyrobetaine, Grindeks, However, Latvia, Meldonium, MET-88, Mildronate, NH, PDB, Quarterine, Some, THP, To
Gene ontology · 14
Gamma-butyrobetaine dioxygenase → carnitine biosynthetic process, cytoplasm, cytosol, dioxygenase activity, extracellular exosome, gamma-butyrobetaine dioxygenase activity, identical protein binding, iron ion binding, metal ion binding, mitochondrion, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, protein binding, zinc ion binding
related to Assay · 8
Gamma-butyrobetaine dioxygenase → Early, Enzyme-coupled, However, NMR, Other, Several, The, Using
related to Reaction · 7
Gamma-butyrobetaine dioxygenase → Ascorbic, Fe, Gamma-butyrobetaine, It, IV, L-carnitine, The
Band · 2
Gamma-butyrobetaine dioxygenase → 11p14.2, 2|2 E3
Chr. · 2
Gamma-butyrobetaine dioxygenase → Chromosome 11 (human), Chromosome 2 (mouse)
End · 2
Gamma-butyrobetaine dioxygenase → 110,144,905 bp, 27,127,809 bp
1.14.11.1 · 1
Gamma-butyrobetaine dioxygenase → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gamma-butyrobetaine dioxygenase mildronate enzyme also human gene bp 2og substrate carnitine bbox1 chr band l-carnitine oxidation acid catalyses activity 11

Gamma-butyrobetaine dioxygenase relationships Subject–Predicate–Object triples

TTTA extracted 113 structured relationships around Gamma-butyrobetaine dioxygenase. Examples in this analysis include Gamma-butyrobetaine dioxygenase → 1.14.11.1 → ↗ and Gamma-butyrobetaine dioxygenase → Aliases → BBOX1, BBH, BBOX, G-BBH, gamma-BBH, gamma-butyrobetaine hydroxylase 1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Gamma-butyrobetaine dioxygenase1.14.11.1↗1.00infobox
Gamma-butyrobetaine dioxygenaseAliasesBBOX1, BBH, BBOX, G-BBH, gamma-BBH, gamma-butyrobetaine hydroxylase 11.00infobox
Gamma-butyrobetaine dioxygenaseAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3MS5, 3N6W, 3O2G, 4BG1, 4BGK, 4BGM, 4BHF, 4BHG, 4BHI, 4C5W, 4C8R, 4CWD1.00infobox
Gamma-butyrobetaine dioxygenaseBand11p14.21.00infobox
Gamma-butyrobetaine dioxygenaseBand2|2 E31.00infobox
Gamma-butyrobetaine dioxygenaseBgeekidney tubule1.00infobox
Gamma-butyrobetaine dioxygenaseBgeeglomerulus1.00infobox
Gamma-butyrobetaine dioxygenaseBgeehuman kidney1.00infobox
Gamma-butyrobetaine dioxygenaseBgeegingival epithelium1.00infobox
Gamma-butyrobetaine dioxygenaseBgeemetanephric glomerulus1.00infobox
Gamma-butyrobetaine dioxygenaseBgeeskin of thigh1.00infobox
Gamma-butyrobetaine dioxygenaseBgeerenal medulla1.00infobox
Gamma-butyrobetaine dioxygenaseBgeeskin of hip1.00infobox
Gamma-butyrobetaine dioxygenaseBgeeexternal globus pallidus1.00infobox
Gamma-butyrobetaine dioxygenaseBgeeskin of arm1.00infobox
Gamma-butyrobetaine dioxygenaseBgeevestibular membrane of cochlear duct1.00infobox
Gamma-butyrobetaine dioxygenaseBgeeleft lobe of liver1.00infobox
Gamma-butyrobetaine dioxygenaseBgeeskin of external ear1.00infobox
Gamma-butyrobetaine dioxygenaseBgeelumbar subsegment of spinal cord1.00infobox
Gamma-butyrobetaine dioxygenaseBgeelip1.00infobox
Gamma-butyrobetaine dioxygenaseBgeeskin of back1.00infobox
Gamma-butyrobetaine dioxygenaseBgeedeep cerebellar nuclei1.00infobox
Gamma-butyrobetaine dioxygenaseBgeeepidermis1.00infobox
Gamma-butyrobetaine dioxygenaseBgeesubstantia nigra1.00infobox
Gamma-butyrobetaine dioxygenaseBgeehair follicle1.00infobox
Gamma-butyrobetaine dioxygenaseBioGPSMore reference expression data1.00infobox
Gamma-butyrobetaine dioxygenaseChr.Chromosome 11 (human)1.00infobox
Gamma-butyrobetaine dioxygenaseChr.Chromosome 2 (mouse)1.00infobox
Gamma-butyrobetaine dioxygenaseDatabasesNCBI: entry; OMA: entry1.00infobox
Gamma-butyrobetaine dioxygenaseEnd27,127,809 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Gamma-butyrobetaine dioxygenase bring nearby vocabulary together. In this analysis, examples include Gamma-butyrobetaine, Activity and Catalytic. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Gamma-butyrobetaine dioxygenase
    • Gamma-butyrobetaine
    • Activity
    • Catalytic
    • Catalyses
    • Mildronate
    • 2og
    • Id
    • Pdb
    • Bbox1
    • Including
    • L-carnitine
    • Also
  • gamma-butyrobetaine dioxygenase
    • Gamma-butyrobetaine
    • Activity
    • Catalytic
    • Catalyses
    • Mildronate
    • 2og
    • L-carnitine
    • Acid
    • Id
    • Pdb
    • Bbox1
    • Including
  • enzyme
    • Hydroxylase
    • Γ-butyrobetaine
    • Bbox1
    • Gene
    • Acid
    • Human
    • Substrate
    • Gamma-butyrobetaine
    • Humans
    • Id
    • Iron
    • Location
  • carnitine biosynthesis
    • Membrane
    • Oxidation
    • Using
    • Data
    • Kidney
    • Liver
    • Mouse
    • Iron
    • Location
    • Oxygen
    • Band
    • Chromosome
  • carnitine
    • Membrane
    • Oxidation
    • Using
    • Data
    • Kidney
    • Liver
    • Mouse
    • Iron
    • Location
    • Oxygen
    • Band
    • Chromosome
  • 2-oxoglutarate (2og)-dependent dioxygenase
    • Gamma-butyrobetaine
    • Oxygenases
    • Human
    • Catalytic
    • Formation
    • Including
    • Activity
    • Catalyses
    • Substrate
    • L-carnitine
    • Mildronate
    • 2og
  • 2og
    • Oxygenases
    • Human
    • Formation
    • Including
    • Substrate
    • Gamma-butyrobetaine
    • Dioxygenase
    • Data
    • Kidney
    • Liver
    • Membrane
    • Mouse
  • enzyme inhibitors
    • Hydroxylase
    • Γ-butyrobetaine
    • Bbox1
    • Gene
    • Acid
    • Human
    • Substrate
    • Gamma-butyrobetaine
    • Humans
    • Id
    • Iron
    • Location

Connections between topic areas Semantic bridges

For Gamma-butyrobetaine dioxygenase, one of the stronger structural bridges in this analysis connects Gamma-butyrobetaine dioxygenase with Reaction. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Gamma-butyrobetaine dioxygenase — Reaction · splits 49 ⟂ 22
Gamma-butyrobetaine dioxygenase — Inhibition · splits 51 ⟂ 20
Gamma-butyrobetaine dioxygenase — Assay · splits 54 ⟂ 17
Gamma-butyrobetaine dioxygenase — Overview · splits 60 ⟂ 11

Map overview Semantic statistics

Gamma-butyrobetaine dioxygenase

Nodes71
Edges70
Triples113
Avg. degree1.97
Density0.028169
Components1

Source & methodology

TTTA analyzes the structure around Gamma-butyrobetaine dioxygenase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Reaction, Inhibition & Assay, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Gamma-butyrobetaine dioxygenase · EN edition · Analysis: TopicsToTalkAbout

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