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Fumarase

Fumarase (or fumarate hydratase) is an enzyme (EC 4.2.1.2) that catalyzes the reversible hydration/dehydration of fumarate to malate. Fumarase comes in two forms: mitochondrial and cytosolic. The mitochondrial isoenzyme is involved in the Krebs cycle and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate. Subcellular…

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4.2.1.2
Aliases
FH, fumarate hydratase, HLRCC, LRCC, MCL, MCUL1, FMRD, Fumarate hydratase, HsFH
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3E04
Band
1q43 · 1|1 H3
Bgee
right ventricle · body of tongue · left ventricle · apex of heart · right auricle of heart
BioGPS
n/a

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Fumarase

Nodes60
Edges59
Triples145
Avg. degree1.97
Density0.033333
Components1

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Fumarase

Top relations

Bgee · 19
Fumarase → apex of heart, atrioventricular valve, body of tongue, brown adipose tissue, digastric muscle, endocardial cushion, gastrocnemius muscle, left ventricle, muscle of thigh, myocardium of left ventricle, myocardium of ventricle, right auricle of heart, right lobe of liver, right ventricle, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, temporal muscle, vastus lateralis muscle
RNA expression pattern · 19
Fumarase → apex of heart, atrioventricular valve, body of tongue, brown adipose tissue, digastric muscle, endocardial cushion, gastrocnemius muscle, left ventricle, muscle of thigh, myocardium of left ventricle, myocardium of ventricle, right auricle of heart, right lobe of liver, right ventricle, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, temporal muscle, vastus lateralis muscle
related to Mechanism · 17
Fumarase → AH/B, BH, Despite, E1, E1cB, E2, Early, Fig, Figure, H2O, However, HR, In E1, S-malate, The, This, Two
Gene ontology · 14
Fumarase → catalytic activity, cytoplasm, extracellular exosome, fumarate hydratase activity, fumarate metabolic process, homeostasis of number of cells within a tissue, lyase activity, malate metabolic process, mitochondrial matrix, mitochondrion, positive regulation of cold-induced thermogenesis, protein binding, tricarboxylic acid cycle, tricarboxylic acid cycle enzyme complex
related to External links · 11
Fumarase → Breakdown, Citric Acid CycleVideo, Fumarate, FumarateStructure, L-Malate Archived, Medicine Medical Subject Headings, MeSH, National Library, S-MalateLink, Structure, Wayback Machine
related to Clinical significance · 9
Fumarase → Germinal, If, In, Inactivity, Isolated, Molecular, Mutations, Reed's, These
related to Subtypes · 9
Fumarase → Class, Class II, Classification, Escherichia, Fe2, II, Prokaryotes, There, They
related to Protein · 8
Fumarase → Active, Crystal, Crystallographic, Escherichia, Even, His129, It, These
related to Other substrates · 6
Fumarase → Both Fumarase, D-tartrate, Enol-oxaloacetate, However, The, This
related to Biochemical pathway · 4
Fumarase → In, NADH, Studies, The

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Important terminology

enzyme fumarate gene mitochondrial bp acid cycle cytosolic malate chr human band carcinoma site deficiency two amino also forms renal

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Fumarase4.2.1.21.00infobox
FumaraseAliasesFH, fumarate hydratase, HLRCC, LRCC, MCL, MCUL1, FMRD, Fumarate hydratase, HsFH1.00infobox
FumaraseAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3E041.00infobox
FumaraseBand1q431.00infobox
FumaraseBand1|1 H31.00infobox
FumaraseBgeeright ventricle1.00infobox
FumaraseBgeebody of tongue1.00infobox
FumaraseBgeeleft ventricle1.00infobox
FumaraseBgeeapex of heart1.00infobox
FumaraseBgeeright auricle of heart1.00infobox
FumaraseBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
FumaraseBgeegastrocnemius muscle1.00infobox
FumaraseBgeeright lobe of liver1.00infobox
FumaraseBgeemuscle of thigh1.00infobox
FumaraseBgeemyocardium of left ventricle1.00infobox
FumaraseBgeeatrioventricular valve1.00infobox
FumaraseBgeemyocardium of ventricle1.00infobox
FumaraseBgeedigastric muscle1.00infobox
FumaraseBgeesternocleidomastoid muscle1.00infobox
FumaraseBgeeendocardial cushion1.00infobox
FumaraseBgeebrown adipose tissue1.00infobox
FumaraseBgeetemporal muscle1.00infobox
FumaraseBgeesoleus muscle1.00infobox
FumaraseBgeevastus lateralis muscle1.00infobox
FumaraseBioGPSn/a1.00infobox
FumaraseChr.Chromosome 1 (human)1.00infobox
FumaraseChr.Chromosome 1 (mouse)1.00infobox
FumaraseDatabasesNCBI: entry; OMA: entry1.00infobox
FumaraseEnd241,519,799 bp1.00infobox
FumaraseEnd175,453,201 bp1.00infobox

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