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Fumarase (or fumarate hydratase) is an enzyme (EC 4.2.1.2) that catalyzes the reversible hydration/dehydration of fumarate to malate. Fumarase comes in two forms: mitochondrial and cytosolic. The mitochondrial isoenzyme is involved in the Krebs cycle and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate. Subcellular…
Standards, Clinical significance & Function
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enzyme fumarate gene mitochondrial bp acid cycle cytosolic malate chr human band carcinoma site deficiency two amino also forms renal
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Fumarase | 4.2.1.2 | ↗ | 1.00 | infobox |
| Fumarase | Aliases | FH, fumarate hydratase, HLRCC, LRCC, MCL, MCUL1, FMRD, Fumarate hydratase, HsFH | 1.00 | infobox |
| Fumarase | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3E04 | 1.00 | infobox |
| Fumarase | Band | 1q43 | 1.00 | infobox |
| Fumarase | Band | 1|1 H3 | 1.00 | infobox |
| Fumarase | Bgee | right ventricle | 1.00 | infobox |
| Fumarase | Bgee | body of tongue | 1.00 | infobox |
| Fumarase | Bgee | left ventricle | 1.00 | infobox |
| Fumarase | Bgee | apex of heart | 1.00 | infobox |
| Fumarase | Bgee | right auricle of heart | 1.00 | infobox |
| Fumarase | Bgee | Skeletal muscle tissue of rectus abdominis | 1.00 | infobox |
| Fumarase | Bgee | gastrocnemius muscle | 1.00 | infobox |
| Fumarase | Bgee | right lobe of liver | 1.00 | infobox |
| Fumarase | Bgee | muscle of thigh | 1.00 | infobox |
| Fumarase | Bgee | myocardium of left ventricle | 1.00 | infobox |
| Fumarase | Bgee | atrioventricular valve | 1.00 | infobox |
| Fumarase | Bgee | myocardium of ventricle | 1.00 | infobox |
| Fumarase | Bgee | digastric muscle | 1.00 | infobox |
| Fumarase | Bgee | sternocleidomastoid muscle | 1.00 | infobox |
| Fumarase | Bgee | endocardial cushion | 1.00 | infobox |
| Fumarase | Bgee | brown adipose tissue | 1.00 | infobox |
| Fumarase | Bgee | temporal muscle | 1.00 | infobox |
| Fumarase | Bgee | soleus muscle | 1.00 | infobox |
| Fumarase | Bgee | vastus lateralis muscle | 1.00 | infobox |
| Fumarase | BioGPS | n/a | 1.00 | infobox |
| Fumarase | Chr. | Chromosome 1 (human) | 1.00 | infobox |
| Fumarase | Chr. | Chromosome 1 (mouse) | 1.00 | infobox |
| Fumarase | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Fumarase | End | 241,519,799 bp | 1.00 | infobox |
| Fumarase | End | 175,453,201 bp | 1.00 | infobox |
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