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Fumarase: Standards, Clinical significance & Function

Fumarase (or fumarate hydratase) is an enzyme (EC 4.2.1.2) that catalyzes the reversible hydration/dehydration of fumarate to malate. Fumarase comes in two forms: mitochondrial and cytosolic. The mitochondrial isoenzyme is involved in the Krebs cycle and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate. Subcellular…

Language: English [EN]
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Fumarase topic overview

The analysis highlights Standards, Clinical significance and Function as prominent areas in the source structure around Fumarase.

Related topics
54
Source areas
5
Connected nodes
59
Extracted relationships
145
Concept neighborhoods
22
Bridge connections
59

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 17 topics
Clinical significance · 16 topics
Function · 14 topics
Structure · 6 topics
Nomenclature · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

4.2.1.2
Aliases
FH, fumarate hydratase, HLRCC, LRCC, MCL, MCUL1, FMRD, Fumarate hydratase, HsFH
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3E04
Band
1q43 · 1|1 H3
Bgee
right ventricle · body of tongue · left ventricle · apex of heart · right auricle of heart
BioGPS
n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Nomenclature

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Fumarase connects Entity context

The extracted context around Fumarase shows recurring relationship patterns in the source. For example, Fumarase → apex of heart, atrioventricular valve, body of tongue, brown adipose tissue, digastric muscle, endocardial cushion, gastrocnemius muscle, left ventricle, muscle of thigh, myocardium of left ventricle, myocardium of ventricle, right auricle of heart, right lobe of liver, right ventricle, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, temporal muscle, vastus lateralis muscle Another extracted example is Fumarase → AH/B, BH, Despite, E1, E1cB, E2, Early, Fig, Figure, H2O, However, HR, In E1, S-malate, The, This, Two. Use these groups to spot repeated connection types before inspecting the individual relationships.

Fumarase

Top relations

Bgee · 19
Fumarase → apex of heart, atrioventricular valve, body of tongue, brown adipose tissue, digastric muscle, endocardial cushion, gastrocnemius muscle, left ventricle, muscle of thigh, myocardium of left ventricle, myocardium of ventricle, right auricle of heart, right lobe of liver, right ventricle, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, temporal muscle, vastus lateralis muscle
RNA expression pattern · 19
Fumarase → apex of heart, atrioventricular valve, body of tongue, brown adipose tissue, digastric muscle, endocardial cushion, gastrocnemius muscle, left ventricle, muscle of thigh, myocardium of left ventricle, myocardium of ventricle, right auricle of heart, right lobe of liver, right ventricle, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, temporal muscle, vastus lateralis muscle
related to Mechanism · 17
Fumarase → AH/B, BH, Despite, E1, E1cB, E2, Early, Fig, Figure, H2O, However, HR, In E1, S-malate, The, This, Two
Gene ontology · 14
Fumarase → catalytic activity, cytoplasm, extracellular exosome, fumarate hydratase activity, fumarate metabolic process, homeostasis of number of cells within a tissue, lyase activity, malate metabolic process, mitochondrial matrix, mitochondrion, positive regulation of cold-induced thermogenesis, protein binding, tricarboxylic acid cycle, tricarboxylic acid cycle enzyme complex
related to External links · 11
Fumarase → Breakdown, Citric Acid CycleVideo, Fumarate, FumarateStructure, L-Malate Archived, Medicine Medical Subject Headings, MeSH, National Library, S-MalateLink, Structure, Wayback Machine
related to Clinical significance · 9
Fumarase → Germinal, If, In, Inactivity, Isolated, Molecular, Mutations, Reed's, These
related to Subtypes · 9
Fumarase → Class, Class II, Classification, Escherichia, Fe2, II, Prokaryotes, There, They
related to Protein · 8
Fumarase → Active, Crystal, Crystallographic, Escherichia, Even, His129, It, These
related to Other substrates · 6
Fumarase → Both Fumarase, D-tartrate, Enol-oxaloacetate, However, The, This
related to Biochemical pathway · 4
Fumarase → In, NADH, Studies, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

enzyme fumarate gene mitochondrial bp acid cycle cytosolic malate chr human band carcinoma site deficiency two amino also forms renal

Fumarase relationships Subject–Predicate–Object triples

TTTA extracted 145 structured relationships around Fumarase. Examples in this analysis include Fumarase → 4.2.1.2 → ↗ and Fumarase → Aliases → FH, fumarate hydratase, HLRCC, LRCC, MCL, MCUL1, FMRD, Fumarate hydratase, HsFH. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Fumarase4.2.1.21.00infobox
FumaraseAliasesFH, fumarate hydratase, HLRCC, LRCC, MCL, MCUL1, FMRD, Fumarate hydratase, HsFH1.00infobox
FumaraseAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3E041.00infobox
FumaraseBand1q431.00infobox
FumaraseBand1|1 H31.00infobox
FumaraseBgeeright ventricle1.00infobox
FumaraseBgeebody of tongue1.00infobox
FumaraseBgeeleft ventricle1.00infobox
FumaraseBgeeapex of heart1.00infobox
FumaraseBgeeright auricle of heart1.00infobox
FumaraseBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
FumaraseBgeegastrocnemius muscle1.00infobox
FumaraseBgeeright lobe of liver1.00infobox
FumaraseBgeemuscle of thigh1.00infobox
FumaraseBgeemyocardium of left ventricle1.00infobox
FumaraseBgeeatrioventricular valve1.00infobox
FumaraseBgeemyocardium of ventricle1.00infobox
FumaraseBgeedigastric muscle1.00infobox
FumaraseBgeesternocleidomastoid muscle1.00infobox
FumaraseBgeeendocardial cushion1.00infobox
FumaraseBgeebrown adipose tissue1.00infobox
FumaraseBgeetemporal muscle1.00infobox
FumaraseBgeesoleus muscle1.00infobox
FumaraseBgeevastus lateralis muscle1.00infobox
FumaraseBioGPSn/a1.00infobox
FumaraseChr.Chromosome 1 (human)1.00infobox
FumaraseChr.Chromosome 1 (mouse)1.00infobox
FumaraseDatabasesNCBI: entry; OMA: entry1.00infobox
FumaraseEnd241,519,799 bp1.00infobox
FumaraseEnd175,453,201 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Fumarase bring nearby vocabulary together. In this analysis, examples include Deficiency, Forms and Mechanism. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Fumarase
    • Deficiency
    • Forms
    • Mechanism
    • Malate
    • Two
    • Mutations
    • Cytosolic
    • Mitochondrial
    • Reaction
    • Acid
    • Gene
    • Fumarate
  • fumarase
    • Deficiency
    • Forms
    • Mechanism
    • Malate
    • Two
    • Mutations
    • Cytosolic
    • Mitochondrial
    • Reaction
    • Acid
    • Gene
    • Fumarate
  • enzyme
    • Acid
    • Hydratase
    • Also
    • Fumarate
    • Cycle
    • Site
    • Dehydration
    • Function
    • Location
    • Metabolic
    • Chromosome
    • Fh
  • fumarate
    • S-malate
    • Malate
    • Cycle
    • Hydratase
    • Reaction
    • Acid
    • Function
    • Location
    • Chromosome
    • E1
    • Fh
    • Human
  • krebs cycle
    • Acid
    • Citric
    • Fumarate
    • Function
    • Metabolic
    • Amino
    • Mitochondrial
    • Enzyme
    • Form
    • Hydratase
    • Location
    • Band
  • citric acid cycle
    • Acid
    • Cycle
    • Citric
    • Fumarate
    • Function
    • Metabolic
    • Enzyme
    • Amino
    • Mitochondrial
    • Form
    • Carcinoma
    • Cell
  • reductive citric acid cycle
    • Acid
    • Cycle
    • Citric
    • Fumarate
    • Function
    • Metabolic
    • Enzyme
    • Amino
    • Mitochondrial
    • Form
    • Carcinoma
    • Cell
  • urea cycle
    • Acid
    • Citric
    • Fumarate
    • Function
    • Metabolic
    • Amino
    • Mitochondrial
    • Enzyme
    • Form
    • Hydratase
    • Location
    • Band

Connections between topic areas Semantic bridges

For Fumarase, one of the stronger structural bridges in this analysis connects Fumarase with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
FumaraseOverview · splits 42 ⟂ 18
FumaraseClinical significance · splits 43 ⟂ 17
FumaraseFunction · splits 45 ⟂ 15
FumaraseStructure · splits 53 ⟂ 7

Map overview Semantic statistics

Fumarase

Nodes60
Edges59
Triples145
Avg. degree1.97
Density0.033333
Components1

Source & methodology

TTTA analyzes the structure around Fumarase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Fumarase · EN edition · Analysis: TopicsToTalkAbout

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