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Fumarase (or fumarate hydratase) is an enzyme (EC 4.2.1.2) that catalyzes the reversible hydration/dehydration of fumarate to malate. Fumarase comes in two forms: mitochondrial and cytosolic. The mitochondrial isoenzyme is involved in the Krebs cycle and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate. Subcellular…
The analysis highlights Standards, Clinical significance and Function as prominent areas in the source structure around Fumarase.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Fumarase shows recurring relationship patterns in the source. For example, Fumarase → apex of heart, atrioventricular valve, body of tongue, brown adipose tissue, digastric muscle, endocardial cushion, gastrocnemius muscle, left ventricle, muscle of thigh, myocardium of left ventricle, myocardium of ventricle, right auricle of heart, right lobe of liver, right ventricle, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, temporal muscle, vastus lateralis muscle Another extracted example is Fumarase → AH/B, BH, Despite, E1, E1cB, E2, Early, Fig, Figure, H2O, However, HR, In E1, S-malate, The, This, Two. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
enzyme fumarate gene mitochondrial bp acid cycle cytosolic malate chr human band carcinoma site deficiency two amino also forms renal
TTTA extracted 145 structured relationships around Fumarase. Examples in this analysis include Fumarase → 4.2.1.2 → ↗ and Fumarase → Aliases → FH, fumarate hydratase, HLRCC, LRCC, MCL, MCUL1, FMRD, Fumarate hydratase, HsFH. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Fumarase | 4.2.1.2 | ↗ | 1.00 | infobox |
| Fumarase | Aliases | FH, fumarate hydratase, HLRCC, LRCC, MCL, MCUL1, FMRD, Fumarate hydratase, HsFH | 1.00 | infobox |
| Fumarase | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3E04 | 1.00 | infobox |
| Fumarase | Band | 1q43 | 1.00 | infobox |
| Fumarase | Band | 1|1 H3 | 1.00 | infobox |
| Fumarase | Bgee | right ventricle | 1.00 | infobox |
| Fumarase | Bgee | body of tongue | 1.00 | infobox |
| Fumarase | Bgee | left ventricle | 1.00 | infobox |
| Fumarase | Bgee | apex of heart | 1.00 | infobox |
| Fumarase | Bgee | right auricle of heart | 1.00 | infobox |
| Fumarase | Bgee | Skeletal muscle tissue of rectus abdominis | 1.00 | infobox |
| Fumarase | Bgee | gastrocnemius muscle | 1.00 | infobox |
| Fumarase | Bgee | right lobe of liver | 1.00 | infobox |
| Fumarase | Bgee | muscle of thigh | 1.00 | infobox |
| Fumarase | Bgee | myocardium of left ventricle | 1.00 | infobox |
| Fumarase | Bgee | atrioventricular valve | 1.00 | infobox |
| Fumarase | Bgee | myocardium of ventricle | 1.00 | infobox |
| Fumarase | Bgee | digastric muscle | 1.00 | infobox |
| Fumarase | Bgee | sternocleidomastoid muscle | 1.00 | infobox |
| Fumarase | Bgee | endocardial cushion | 1.00 | infobox |
| Fumarase | Bgee | brown adipose tissue | 1.00 | infobox |
| Fumarase | Bgee | temporal muscle | 1.00 | infobox |
| Fumarase | Bgee | soleus muscle | 1.00 | infobox |
| Fumarase | Bgee | vastus lateralis muscle | 1.00 | infobox |
| Fumarase | BioGPS | n/a | 1.00 | infobox |
| Fumarase | Chr. | Chromosome 1 (human) | 1.00 | infobox |
| Fumarase | Chr. | Chromosome 1 (mouse) | 1.00 | infobox |
| Fumarase | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Fumarase | End | 241,519,799 bp | 1.00 | infobox |
| Fumarase | End | 175,453,201 bp | 1.00 | infobox |
The concept neighborhoods around Fumarase bring nearby vocabulary together. In this analysis, examples include Deficiency, Forms and Mechanism. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Fumarase, one of the stronger structural bridges in this analysis connects Fumarase with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Fumarase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Fumarase · EN edition · Analysis: TopicsToTalkAbout