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ESCO2: Function, Clinical significance & Overview

N-acetyltransferase ESCO2, also known as establishment of cohesion 1 homolog 2 or ECO1 homolog 2, is an enzyme that in humans is encoded by the ESCO2 gene.

Language: English [EN]
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ESCO2 topic overview

The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around ESCO2.

Related topics
8
Source areas
3
Connected nodes
11
Extracted relationships
84
Related term clusters
11
Bridge connections
11

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 4 topics
Clinical significance · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ESCO2, 2410004I17Rik, EFO2, RBS, establishment of sister chromatid cohesion N-acetyltransferase 2, EFO2p, hEFO2, JHS
Band
8p21.1 · 14|14 D1
Bgee
oocyte · buccal mucosa cell · secondary oocyte · gonad · testicle
BioGPS
n/a
Chr.
Chromosome 8 (human) · Chromosome 14 (mouse)
Databases
NCBI: entry; OMA: entry

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ESCO2
4Acetyltransferase · Cohesin · S phase
4Enzyme · Gene · Roberts syndrome

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How ESCO2 connects Entity context

The extracted context around ESCO2 shows recurring relationship patterns in the source. For example, ESCO2 → acetyltransferase activity, acyltransferase activity, cell cycle, cell junction, chromatin, chromocenter, chromosome, chromosome segregation, double-strand break repair, Golgi apparatus, hematopoietic progenitor cell differentiation, lysine N-acetyltransferase activity, acting on acetyl phosphate as donor, metal ion binding, N-acetyltransferase activity, nucleoplasm, nucleus, post-translational protein acetylation, protein localization to chromatin, regulation of DNA replication, sister chromatid cohesion Another extracted example is ESCO2 → blastocyst, bone marrow cell, buccal mucosa cell, ganglionic eminence, genital tubercle, gonad, Gonadal ridge, hand, morula, oocyte, primary oocyte, rectum, secondary oocyte, spermatogonium, stromal cell of endometrium, tail of embryo, testicle, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

ESCO2

Top relations

Gene ontology · 23
ESCO2 → acetyltransferase activity, acyltransferase activity, cell cycle, cell junction, chromatin, chromocenter, chromosome, chromosome segregation, double-strand break repair, Golgi apparatus, hematopoietic progenitor cell differentiation, lysine N-acetyltransferase activity, acting on acetyl phosphate as donor, metal ion binding, N-acetyltransferase activity, nucleoplasm, nucleus, post-translational protein acetylation, protein localization to chromatin, regulation of DNA replication, sister chromatid cohesion
Bgee · 19
ESCO2 → blastocyst, bone marrow cell, buccal mucosa cell, ganglionic eminence, genital tubercle, gonad, Gonadal ridge, hand, morula, oocyte, primary oocyte, rectum, secondary oocyte, spermatogonium, stromal cell of endometrium, tail of embryo, testicle, ventricular zone, zygote
RNA expression pattern · 19
ESCO2 → blastocyst, bone marrow cell, buccal mucosa cell, ganglionic eminence, genital tubercle, gonad, Gonadal ridge, hand, morula, oocyte, primary oocyte, rectum, secondary oocyte, spermatogonium, stromal cell of endometrium, tail of embryo, testicle, ventricular zone, zygote
related to Clinical significance · 3
ESCO2 → Juberg-Hayward Syndrome, Mutations, Roberts
Band · 2
ESCO2 → 14|14 D1, 8p21.1
Chr. · 2
ESCO2 → Chromosome 14 (mouse), Chromosome 8 (human)
End · 2
ESCO2 → 27,812,640 bp, 66,071,443 bp
Aliases · 1
ESCO2 → ESCO2, 2410004I17Rik, EFO2, RBS, establishment of sister chromatid cohesion N-acetyltransferase 2, EFO2p, hEFO2, JHS
BioGPS · 1
ESCO2 → n/a
Databases · 1
ESCO2 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene cohesion chr human chromosome band establishment sister chromatid n-acetyltransferase location also mouse function external 812 640 end 27

ESCO2 relationships Subject–Predicate–Object triples

TTTA extracted 84 structured relationships around ESCO2. Examples in this analysis include ESCO2 → Aliases → ESCO2, 2410004I17Rik, EFO2, RBS, establishment of sister chromatid cohesion N-acetyltransferase 2, EFO2p, hEFO2, JHS and ESCO2 → Band → 8p21.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ESCO2AliasesESCO2, 2410004I17Rik, EFO2, RBS, establishment of sister chromatid cohesion N-acetyltransferase 2, EFO2p, hEFO2, JHS1.00infobox
ESCO2Band8p21.11.00infobox
ESCO2Band14|14 D11.00infobox
ESCO2Bgeeoocyte1.00infobox
ESCO2Bgeebuccal mucosa cell1.00infobox
ESCO2Bgeesecondary oocyte1.00infobox
ESCO2Bgeegonad1.00infobox
ESCO2Bgeetesticle1.00infobox
ESCO2Bgeeventricular zone1.00infobox
ESCO2Bgeeganglionic eminence1.00infobox
ESCO2Bgeebone marrow cell1.00infobox
ESCO2Bgeestromal cell of endometrium1.00infobox
ESCO2Bgeerectum1.00infobox
ESCO2Bgeezygote1.00infobox
ESCO2Bgeehand1.00infobox
ESCO2Bgeespermatogonium1.00infobox
ESCO2Bgeemorula1.00infobox
ESCO2Bgeeprimary oocyte1.00infobox
ESCO2Bgeeblastocyst1.00infobox
ESCO2Bgeetail of embryo1.00infobox
ESCO2Bgeegenital tubercle1.00infobox
ESCO2BgeeGonadal ridge1.00infobox
ESCO2BioGPSn/a1.00infobox
ESCO2Chr.Chromosome 8 (human)1.00infobox
ESCO2Chr.Chromosome 14 (mouse)1.00infobox
ESCO2DatabasesNCBI: entry; OMA: entry1.00infobox
ESCO2End27,812,640 bp1.00infobox
ESCO2End66,071,443 bp1.00infobox
ESCO2EnsemblENSG000001713201.00infobox
ESCO2Entrez1575701.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around ESCO2 bring nearby vocabulary together. In this analysis, examples include Gene, N-acetyltransferase and Cohesion. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • ESCO2
    • Gene
    • N-acetyltransferase
    • Cohesion
    • Establishment
    • Also
    • Function
    • Chromatid
    • Location
    • Sister
    • Chromosome
    • Human
    • Bp
  • esco2
    • Gene
    • N-acetyltransferase
    • Cohesion
    • Establishment
    • Also
    • Function
    • Chromatid
    • Location
    • Sister
    • Chromosome
    • Human
    • Bp
  • gene
    • Location
    • N-acetyltransferase
    • Chromosome
    • Human
    • Bp
    • Chr
    • End
    • Function
    • Mouse
    • Chromatid
    • Sister
    • Band
  • cohesion
    • Establishment
    • Chromatid
    • N-acetyltransferase
    • Sister
    • Esco2
    • Clinical
    • Entry
    • Function
    • Gene
    • Ncbi
    • Significance
    • Location
  • acetyltransferase
    • Activity
    • Cell
    • Cycle
    • Protein
    • End
    • Entry
    • Function
    • Mouse
    • Ncbi
    • Chromatid
    • Location
    • N-acetyltransferase
  • function
    • Chromatid
    • Location
    • N-acetyltransferase
    • Sister
    • Acetyltransferase
    • Activity
    • Cell
    • Chromosome
    • Cycle
    • External
    • Human
    • Protein
  • cell cycle
    • Acetyltransferase
    • Activity
    • Cycle
    • Protein
    • End
    • Entry
    • Function
    • Mouse
    • Ncbi
    • Chromatid
    • Location
    • N-acetyltransferase
  • clinical significance
    • Significance
    • Chromatid
    • Sister
    • Cohesion
    • Establishment
    • External
    • Entry
    • Function
    • Ncbi
    • Roberts
    • Syndrome
    • Location

Connections between topic areas Semantic bridges

For ESCO2, one of the stronger structural bridges in this analysis connects ESCO2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ESCO2 — Function · splits 7 ⟂ 5
ESCO2 — Overview · splits 9 ⟂ 3
ESCO2 — Clinical significance · splits 9 ⟂ 3

Map overview Semantic statistics

ESCO2

Nodes12
Edges11
Triples84
Avg. degree1.83
Density0.166667
Components1

Source & methodology

TTTA analyzes the structure around ESCO2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ESCO2 · EN edition · Analysis: TopicsToTalkAbout

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