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End-sequence profiling

End-sequence profiling (ESP) (sometimes "Paired-end mapping (PEM)") is a method based on sequence-tagged connectors developed to facilitate de novo genome sequencing to identify high-resolution copy number and structural aberrations such as inversions and translocations.

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History & Applications

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ESP history

1 related topics

ESP applications

1 related topics

Structural aberration detection

2 related topics

Artificial chromosome construction

1 related topics

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Overview

Artificial chromosome construction

Structural aberration detection

ESP history

ESP applications

Advanced semantic analysis

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End-sequence profiling

Nodes15
Edges14
Triples26
Avg. degree1.87
Density0.133333
Components1

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End-sequence profiling

Top relations

has application · 16
End-sequence profiling → Accurate, BIPES, BreakDancer, Common, ESP, For, GASV, Illumina, LAW, PEMer, Similar, Spanner, This, V6, Variation Hunter, Various

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Important terminology

genome esp reference structural copy bac fragments chromosome variation number used dna artificial mapping sequencing paired-end insertion inversions cnv size

Entity relationships Subject–Predicate–Object triples

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SubjectPredicateObjectConfidenceSrc
inversionsinstance ofis a method based on sequence-tagged connectors developed to facilitate de novo genome sequencing to identify high-resolution copy number and structural aberrations0.80text
translocations.Brieflyinstance ofis a method based on sequence-tagged connectors developed to facilitate de novo genome sequencing to identify high-resolution copy number and structural aberrations0.80text
the target genomic DNA is isolatedinstance ofis a method based on sequence-tagged connectors developed to facilitate de novo genome sequencing to identify high-resolution copy number and structural aberrations0.80text
partially digested with restriction enzymes into large fragmentsinstance ofis a method based on sequence-tagged connectors developed to facilitate de novo genome sequencing to identify high-resolution copy number and structural aberrations0.80text
bacterial artificial chromosomesinstance ofthe fragments are cloned into plasmids to construct artificial chromosomes0.80text
insertionsinstance ofcan be used to detect structural variations0.80text
deletionsinstance ofcan be used to detect structural variations0.80text
and chromosomal rearrangementinstance ofcan be used to detect structural variations0.80text
inversionsinstance ofESP is particularly useful to identify copy neutral abnormalities0.80text
translocations that would not be apparent when looking at copy number variationinstance ofESP is particularly useful to identify copy neutral abnormalities0.80text
End-sequence profilinghas applicationVarious0.60section
End-sequence profilinghas applicationCommon0.60section

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