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DMRT1: Structure, Function & Clinical significance

Doublesex and mab-3 related transcription factor 1, also known as DMRT1, is a protein which in humans is encoded by the DMRT1 gene.

Language: English [EN]
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DMRT1 topic overview

The analysis highlights Structure, Function and Clinical significance as prominent areas in the source structure around DMRT1.

Related topics
9
Source areas
4
Connected nodes
13
Extracted relationships
125
Concept neighborhoods
8
Bridge connections
13

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 3 topics
Clinical significance · 2 topics
Function · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DMRT1, CT154, DMT1, doublesex and mab-3 related transcription factor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4YJ0
Band
9p24.3 · 19|19 B
Bgee
gonad · testicle · buccal mucosa cell · right testis · left testis
BioGPS
More reference expression data
Chr.
Chromosome 9 (human) · Chromosome 19 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How DMRT1 connects Entity context

The extracted context around DMRT1 shows recurring relationship patterns in the source. For example, DMRT1 → cell differentiation, cell morphogenesis, chromatin binding, cis-regulatory region sequence-specific DNA binding, cytoplasm, developmental process involved in reproduction, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, germ cell migration, identical protein binding, intracellular signal transduction, male germ cell proliferation, male gonad development, male sex determination, male sex differentiation, metal ion binding, multicellular organism development, negative regulation of meiotic nuclear division Another extracted example is DMRT1 → buccal mucosa cell, embryo, epithelium of seminiferous tubule of testis, germ cell, gonad, Gonadal ridge, left testis, male germ cell, morula, olfactory zone of nasal mucosa, placenta, right testis, seminiferous tubule, Sertoli cell, spermatid, spermatocyte, spermatogonium, testicle, thyroid gland. Use these groups to spot repeated connection types before inspecting the individual relationships.

DMRT1

Top relations

Gene ontology · 39
DMRT1 → cell differentiation, cell morphogenesis, chromatin binding, cis-regulatory region sequence-specific DNA binding, cytoplasm, developmental process involved in reproduction, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, germ cell migration, identical protein binding, intracellular signal transduction, male germ cell proliferation, male gonad development, male sex determination, male sex differentiation, metal ion binding, multicellular organism development, negative regulation of meiotic nuclear division
Bgee · 19
DMRT1 → buccal mucosa cell, embryo, epithelium of seminiferous tubule of testis, germ cell, gonad, Gonadal ridge, left testis, male germ cell, morula, olfactory zone of nasal mucosa, placenta, right testis, seminiferous tubule, Sertoli cell, spermatid, spermatocyte, spermatogonium, testicle, thyroid gland
RNA expression pattern · 19
DMRT1 → buccal mucosa cell, embryo, epithelium of seminiferous tubule of testis, germ cell, gonad, Gonadal ridge, left testis, male germ cell, morula, olfactory zone of nasal mucosa, placenta, right testis, seminiferous tubule, Sertoli cell, spermatid, spermatocyte, spermatogonium, testicle, thyroid gland
related to External links · 12
DMRT1 → Doublesex, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Overview, PDB, PDBe-KB, Q9Y5R6, This, UniProt, United States National Library
related to Structure · 5
DMRT1 → DM, DNA-binding, Sertoli, The, The DM
related to Clinical significance · 3
DMRT1 → Defective, Loss, XY
related to Function · 3
DMRT1 → Sertoli, The, Two
Band · 2
DMRT1 → 19|19 B, 9p24.3
Chr. · 2
DMRT1 → Chromosome 19 (mouse), Chromosome 9 (human)
End · 2
DMRT1 → 25,581,693 bp, 969,090 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene chromosome bp human factor chr band transcription sertoli germ male development cells protein location testicular end mouse cell developmental

DMRT1 relationships Subject–Predicate–Object triples

TTTA extracted 125 structured relationships around DMRT1. Examples in this analysis include DMRT1 → Aliases → DMRT1, CT154, DMT1, doublesex and mab-3 related transcription factor 1 and DMRT1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4YJ0. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DMRT1AliasesDMRT1, CT154, DMT1, doublesex and mab-3 related transcription factor 11.00infobox
DMRT1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4YJ01.00infobox
DMRT1Band9p24.31.00infobox
DMRT1Band19|19 B1.00infobox
DMRT1Bgeegonad1.00infobox
DMRT1Bgeetesticle1.00infobox
DMRT1Bgeebuccal mucosa cell1.00infobox
DMRT1Bgeeright testis1.00infobox
DMRT1Bgeeleft testis1.00infobox
DMRT1Bgeeolfactory zone of nasal mucosa1.00infobox
DMRT1Bgeegerm cell1.00infobox
DMRT1Bgeemale germ cell1.00infobox
DMRT1Bgeeplacenta1.00infobox
DMRT1Bgeethyroid gland1.00infobox
DMRT1BgeeGonadal ridge1.00infobox
DMRT1Bgeeseminiferous tubule1.00infobox
DMRT1Bgeeepithelium of seminiferous tubule of testis1.00infobox
DMRT1BgeeSertoli cell1.00infobox
DMRT1Bgeespermatogonium1.00infobox
DMRT1Bgeespermatid1.00infobox
DMRT1Bgeemorula1.00infobox
DMRT1Bgeeembryo1.00infobox
DMRT1Bgeespermatocyte1.00infobox
DMRT1BioGPSMore reference expression data1.00infobox
DMRT1Chr.Chromosome 9 (human)1.00infobox
DMRT1Chr.Chromosome 19 (mouse)1.00infobox
DMRT1DatabasesNCBI: entry; OMA: entry1.00infobox
DMRT1End969,090 bp1.00infobox
DMRT1End25,581,693 bp1.00infobox
DMRT1EnsemblENSG000001370901.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around DMRT1 bring nearby vocabulary together. In this analysis, examples include Cells, Germ and Sertoli. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DMRT1
    • Cells
    • Germ
    • Sertoli
    • Gene
    • Protein
    • Transcription
    • Chromosome
    • Development
    • Factor
    • Male
    • Cell
    • Formation
  • dmrt1
    • Cells
    • Germ
    • Sertoli
    • Gene
    • Protein
    • Transcription
    • Chromosome
    • Development
    • Factor
    • Male
    • Cell
    • Formation
  • gene
    • Chromosome
    • Development
    • Location
    • Bp
    • Chr
    • Human
    • Transcription
    • Male
    • End
    • Function
    • Humans
    • Known
  • chromosome 9p deletion
    • Bp
    • Human
    • Location
    • Band
    • End
    • Function
    • Gene
    • Mouse
    • Search
    • Located
    • Dmrt1
    • Transcription
  • function
    • Search
    • Location
    • External
    • Bp
    • Chr
    • Human
    • Transcription
    • Chromosome
    • End
    • Humans
    • Mab-3
    • Mouse
  • protein
    • Located
    • Human
    • Sertoli
    • Transcription
    • Germ
    • End
    • Function
    • Mouse
    • Q9y5r6
    • Related
    • Search
    • Uniprot
  • sertoli cells
    • Germ
    • Cells
    • Sertoli
    • Mice
    • Dmrt1
    • Formation
    • Testicular
    • Transcription
    • Male
    • Q9y5r6
    • Uniprot
    • Developmental
  • dm domain
    • Known
    • Found
    • Factor
    • Male
    • Gene

Connections between topic areas Semantic bridges

For DMRT1, one of the stronger structural bridges in this analysis connects DMRT1 with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DMRT1Structure · splits 10 ⟂ 4
DMRT1Overview · splits 11 ⟂ 3
DMRT1Function · splits 11 ⟂ 3
DMRT1Clinical significance · splits 11 ⟂ 3

Map overview Semantic statistics

DMRT1

Nodes14
Edges13
Triples125
Avg. degree1.86
Density0.142857
Components1

Source & methodology

TTTA analyzes the structure around DMRT1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DMRT1 · EN edition · Analysis: TopicsToTalkAbout

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