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DLL3: Standards, Function & Clinical significance

Delta-like 3 (Drosophila), also known as DLL3, is a protein which in humans is encoded by the DLL3 gene. Two transcript variants encoding distinct isoforms have been identified for this gene.

Language: English [EN]
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DLL3 topic overview

The analysis highlights Standards, Function and Clinical significance as prominent areas in the source structure around DLL3.

Related topics
10
Source areas
3
Connected nodes
13
Extracted relationships
82
Related term clusters
8
Bridge connections
13

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 4 topics
Function · 4 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DLL3, SCDO1, pu, pudgy, delta like canonical Notch ligand 3
Band
19q13.2 · 7 A3|7 16.67 cM
Bgee
ganglionic eminence · gonad · testicle · ventricular zone · nucleus accumbens
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 7 (mouse)
Databases
NCBI: entry; OMA: entry

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DLL3
4Notch signaling pathway · EGF-like domain · Somitogenesis
6Protein · Gene · Spondylocostal dysostosis

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How DLL3 connects Entity context

The extracted context around DLL3 shows recurring relationship patterns in the source. For example, DLL3 → amygdala, anterior cingulate cortex, embryo, epiblast, ganglionic eminence, gonad, hypothalamus, medial ganglionic eminence, morula, nucleus accumbens, pars intermedia, prefrontal cortex, primitive streak, putamen, seminiferous tubule, spermatid, tail of embryo, testicle, ventricular zone Another extracted example is DLL3 → calcium ion binding, cell differentiation, compartment pattern specification, integral component of membrane, membrane, multicellular organism development, negative regulation of neurogenesis, Notch binding, Notch signaling pathway, paraxial mesoderm development, plasma membrane, skeletal system development, somitogenesis, tissue development. Use these groups to spot repeated connection types before inspecting the individual relationships.

DLL3

Top relations

Bgee · 19
DLL3 → amygdala, anterior cingulate cortex, embryo, epiblast, ganglionic eminence, gonad, hypothalamus, medial ganglionic eminence, morula, nucleus accumbens, pars intermedia, prefrontal cortex, primitive streak, putamen, seminiferous tubule, spermatid, tail of embryo, testicle, ventricular zone
RNA expression pattern · 19
DLL3 → amygdala, anterior cingulate cortex, embryo, epiblast, ganglionic eminence, gonad, hypothalamus, medial ganglionic eminence, morula, nucleus accumbens, pars intermedia, prefrontal cortex, primitive streak, putamen, seminiferous tubule, spermatid, tail of embryo, testicle, ventricular zone
Gene ontology · 14
DLL3 → calcium ion binding, cell differentiation, compartment pattern specification, integral component of membrane, membrane, multicellular organism development, negative regulation of neurogenesis, Notch binding, Notch signaling pathway, paraxial mesoderm development, plasma membrane, skeletal system development, somitogenesis, tissue development
related to Clinical significance · 6
DLL3 → Experimental, Expression, Jarcho-Levin, Mutations, Neuroendocrine, Tarlatamab
related to Function · 4
DLL3 → DSL, EGF, Expression, Notch
Band · 2
DLL3 → 19q13.2, 7 A3|7 16.67 cM
Chr. · 2
DLL3 → Chromosome 19 (human), Chromosome 7 (mouse)
End · 2
DLL3 → 28,001,663 bp, 39,508,481 bp
Aliases · 1
DLL3 → DLL3, SCDO1, pu, pudgy, delta like canonical Notch ligand 3
BioGPS · 1
DLL3 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp chr human band chromosome 19 protein location notch mouse expression function external somitogenesis 508 481 end 39 a3

DLL3 relationships Subject–Predicate–Object triples

TTTA extracted 82 structured relationships around DLL3. Examples in this analysis include DLL3 → Aliases → DLL3, SCDO1, pu, pudgy, delta like canonical Notch ligand 3 and DLL3 → Band → 19q13.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DLL3AliasesDLL3, SCDO1, pu, pudgy, delta like canonical Notch ligand 31.00infobox
DLL3Band19q13.21.00infobox
DLL3Band7 A3|7 16.67 cM1.00infobox
DLL3Bgeeganglionic eminence1.00infobox
DLL3Bgeegonad1.00infobox
DLL3Bgeetesticle1.00infobox
DLL3Bgeeventricular zone1.00infobox
DLL3Bgeenucleus accumbens1.00infobox
DLL3Bgeeamygdala1.00infobox
DLL3Bgeeanterior cingulate cortex1.00infobox
DLL3Bgeeprefrontal cortex1.00infobox
DLL3Bgeehypothalamus1.00infobox
DLL3Bgeeputamen1.00infobox
DLL3Bgeemedial ganglionic eminence1.00infobox
DLL3Bgeeseminiferous tubule1.00infobox
DLL3Bgeetail of embryo1.00infobox
DLL3Bgeeprimitive streak1.00infobox
DLL3Bgeeembryo1.00infobox
DLL3Bgeeepiblast1.00infobox
DLL3Bgeespermatid1.00infobox
DLL3Bgeemorula1.00infobox
DLL3Bgeepars intermedia1.00infobox
DLL3BioGPSMore reference expression data1.00infobox
DLL3Chr.Chromosome 19 (human)1.00infobox
DLL3Chr.Chromosome 7 (mouse)1.00infobox
DLL3DatabasesNCBI: entry; OMA: entry1.00infobox
DLL3End39,508,481 bp1.00infobox
DLL3End28,001,663 bp1.00infobox
DLL3EnsemblENSG000000909321.00infobox
DLL3Entrez106831.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around DLL3 bring nearby vocabulary together. In this analysis, examples include Delta, Function and Ligand. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • DLL3
    • Delta
    • Function
    • Ligand
    • Protein
    • Expression
    • Gene
    • Location
    • Notch
    • Chromosome
    • Human
    • Bp
    • Chr
  • dll3
    • Delta
    • Function
    • Ligand
    • Protein
    • Expression
    • Gene
    • Location
    • Notch
    • Chromosome
    • Human
    • Bp
    • Chr
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • A3
    • Delta
    • End
    • Function
    • Ligand
    • Mouse
    • Pathway
  • somitogenesis
    • Mesoderm
    • Paraxial
    • A3
    • Delta
    • End
    • Entry
    • Family
    • Function
    • Ligand
    • Mouse
    • Ncbi
    • Pathway
  • function
    • Ligand
    • Location
    • Notch
    • Chromosome
    • Human
    • Bp
    • Chr
    • A3
    • End
    • Entry
    • Family
    • Mesoderm
  • paraxial mesoderm
    • Paraxial
    • Somitogenesis
    • Entry
    • Family
    • Mouse
    • Ncbi
    • Pathway
    • Protein
    • Notch
  • notch ligands
    • Ncbi
    • Paraxial
    • Pathway
    • Protein
    • Somitogenesis
  • protein
    • Somitogenesis

Connections between topic areas Semantic bridges

For DLL3, one of the stronger structural bridges in this analysis connects DLL3 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DLL3 — Function · splits 9 ⟂ 5
DLL3 — Clinical significance · splits 9 ⟂ 5
DLL3 — Overview · splits 11 ⟂ 3

Map overview Semantic statistics

DLL3

Nodes14
Edges13
Triples82
Avg. degree1.86
Density0.142857
Components1

Source & methodology

TTTA analyzes the structure around DLL3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — DLL3 · EN edition · Analysis: TopicsToTalkAbout

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