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Complex traits

Complex traits, also known as polygenic or multigenic traits, are phenotypes determined by the interaction of multiple genetic and environmental factors. A central goal of contemporary genetics research is to understand the molecular mechanisms by which genetic variation influences complex traits. Examples of complex traits in humans include height…

History, Methods for finding complex traits & Genetic architecture

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Overview

History

Types of complex traits

Methods for finding complex traits

Genetic architecture

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Map overview Semantic statistics

Complex traits

Nodes63
Edges62
Triples66
Avg. degree1.97
Density0.031746
Components1

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Complex traits

Top relations

related to Genetic architecture · 14
Complex traits → Differing, Genetic, GWAS, GWASs, Many, One, QTL, QTLs, Recently, RNA, RNA-sequencing, This, To, With
related to GWAS · 14
Complex traits → Both, DNA, Genome-Wide Association Study, GWAS, It, Manhattan, QTL, SNP, SNPs, Statistical, The, Then, This, With
related to QTL mapping · 13
Complex traits → After, From, Many, QTL, Quantitative Trait Loci, Researchers, RFLPs, SNPs, The, These, They, This, To
related to history · 12
Complex traits → After, GWASs, However, Human Genome Project, Later, Mendel's, Mendelian, One, Ronald Fisher, When Mendel's, While, Work
related to Twin studies · 4
Complex traits → DNA, Monozygotic, They, Twin

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Important terminology

traits complex trait genetic genes variants many gwas quantitative factors architecture one different researchers environmental studies qtl mapping phenotypes example

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
diabetesinstance ofand risk for complex diseases0.80text
heart diseaseinstance ofand risk for complex diseases0.80text
Alzheimer's diseaseinstance ofand risk for complex diseases0.80text
and schizophrenia.The genetic architecture of complex traits has been explored using statistical approaches such as genome-wide association studiesinstance ofand risk for complex diseases0.80text
height were largely heritableinstance ofOne group known as the biometricians argued that continuous traits0.80text
but could not be explained by the inheritance of single Mendelian genetic factorsinstance ofOne group known as the biometricians argued that continuous traits0.80text
autisminstance ofalthough in certain traits0.80text
rare variants play a more dominant roleinstance ofalthough in certain traits0.80text
SNPs or RFLPsinstance ofResearchers will then genotype the parents using molecular markers0.80text
Complex traitsrelated to Genetic architectureGenetic0.60section
Complex traitsrelated to Genetic architectureWith0.60section
Complex traitsrelated to Genetic architectureGWAS0.60section

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