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Bococizumab

Bococizumab (USAN; development code RN316) is a drug that was in development by Pfizer targeting PCSK9 to reduce LDL cholesterol. Pfizer withdrew the drug from development in November 2016, determining that it was "not likely to provide value to patients, physicians or shareholders."

Description, Clinical trials & Overview

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Description

Monoclonal antibodyProteinCardiovascular disease
3 related topics

Clinical trials

StatinLDL-CPhase 3
3 related topics

Overview

USANDevelopmentPfizerPCSK9LDL
6 related topics

Key facts & relationships

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ATC code
none
CAS Number
1407495-02-6
ChEMBL
ChEMBL3137349
ChemSpider
none
Formula
C6414H9918N1722O2012S54
IUPHAR/BPS
7730

Topics to explore

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Overview

Description

Clinical trials

Advanced semantic analysis

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Map overview Semantic statistics

Bococizumab

Nodes16
Edges15
Triples28
Avg. degree1.88
Density0.125
Components1

How this topic connects Entity context

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Bococizumab

Top relations

related to Clinical trials · 11
Bococizumab → After, American College, Cardiology, LDL, LDL-C, Monthly, Pfizer, SPIRE, The, The Phase, Wide
related to Description · 2
Bococizumab → LDL, PCSK9
ATC code · 1
Bococizumab → none
CAS Number · 1
Bococizumab → 1407495-02-6
ChEMBL · 1
Bococizumab → ChEMBL3137349
ChemSpider · 1
Bococizumab → none
Formula · 1
Bococizumab → C6414H9918N1722O2012S54
IUPHAR/BPS · 1
Bococizumab → 7730
KEGG · 1
Bococizumab → D10621 Y
Legal status · 1
Bococizumab → Investigational

Important terminology Word statistics

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Important terminology

ldl development pfizer pcsk9 cholesterol drug code levels antibodies reduce patients trials antibody usan phase significantly anti-drug rn316 targeting withdrew

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
BococizumabATC codenone1.00infobox
BococizumabCAS Number1407495-02-61.00infobox
BococizumabChEMBLChEMBL31373491.00infobox
BococizumabChemSpidernone1.00infobox
BococizumabFormulaC6414H9918N1722O2012S541.00infobox
BococizumabIUPHAR/BPS77301.00infobox
BococizumabKEGGD10621 Y1.00infobox
BococizumabLegal statusInvestigational1.00infobox
BococizumabMolar mass145077.18 g·mol−11.00infobox
BococizumabPubChem SID1941685541.00infobox
BococizumabRoutes of administrationSubcutaneous injection1.00infobox
BococizumabSourceHumanized (from mouse)1.00infobox
BococizumabTargetProprotein convertase subtilisin/kexin type 9 (PCSK9)1.00infobox
BococizumabTypeWhole antibody1.00infobox
BococizumabUNII45M75JVK381.00infobox

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