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Alteplase

Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic stroke, acute ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous…

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Key facts & relationships

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AHFS/Drugs.com
Monograph
ATC code
B01AD02 (WHO) S01XA13 (WHO)
CAS Number
105857-23-6
ChemSpider
none
Drug class
Tissue plasminogen activator
DrugBank
DB00009

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Overview

Medical uses

Contraindications

Adverse effects

Mechanism of action

History

Society and culture

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Map overview Semantic statistics

Alteplase

Nodes48
Edges47
Triples81
Avg. degree1.96
Density0.041667
Components1

How this topic connects Entity context

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Alteplase

Top relations

related to Legal status · 11
Alteplase → After, Drug Administration, FDA, Genentech, In May, November, PA, The, This, United States, US Food
related to Contraindications · 6
Alteplase → Active, Additional, Contraindications, People, STEMI, The
related to Pulmonary embolism · 6
Alteplase → As, Drug Administration, However, PE, Systemic, US Food
related to Blocked catheters · 5
Alteplase → Catheter, Currently, Novel, Overall, United States
related to history · 5
Alteplase → In, National Institute, Neurological Disorders, Stroke, This
Legal status · 4
Alteplase → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, US: ℞-only
is a · 4
Alteplase → most commonly used medication to treat pulmonary embolism, same as the normal human plasminogen activator produced in vascular endothelial cells and is synthesized via recombinant DNA technology in Chinese hamster ovary cells, standard of care, thrombolytic medication
has effect · 4
Alteplase → Adverse, Angioedema, Given, Other
related to Brand names · 3
Alteplase → Actilyse, Activase, Cathflo Activase
related to Economics · 3
Alteplase → However, The, United States

Important terminology Word statistics

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Important terminology

ischemic stroke plasminogen acute used catheter activator blood treatment blocked may treat adverse pulmonary embolism administration t-pa thrombolytic fibrinolysis catheters

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
AlteplaseAHFS/Drugs.comMonograph1.00infobox
AlteplaseATC codeB01AD02 (WHO) S01XA13 (WHO)1.00infobox
AlteplaseCAS Number105857-23-61.00infobox
AlteplaseChemSpidernone1.00infobox
AlteplaseDrug classTissue plasminogen activator1.00infobox
AlteplaseDrugBankDB000091.00infobox
AlteplaseFormulaC2569H3928N746O781S401.00infobox
AlteplaseKEGGD028371.00infobox
AlteplaseLegal statusAU: S4 (Prescription only)1.00infobox
AlteplaseLegal statusCA: ℞-only1.00infobox
AlteplaseLegal statusUS: ℞-only1.00infobox
AlteplaseLegal statusEU: Rx-only1.00infobox
AlteplaseLicense dataUS DailyMed: Alteplase1.00infobox
AlteplaseMedlinePlusa6250011.00infobox
AlteplaseMolar mass59042.52 g·mol−11.00infobox
AlteplaseOther namest-PA, rt-PA1.00infobox
AlteplasePregnancy categoryAU: B11.00infobox
AlteplaseRoutes of administrationIntravenous1.00infobox
AlteplaseTrade namesActivase, others1.00infobox
AlteplaseUNII1RXS4UE5641.00infobox
Alteplasecausesthe breakdown of a clot by inducing fibrinolysis.It is on the World Health Organization's List of Essential Medicines0.90text
Alteplaseis asame as the normal human plasminogen activator produced in vascular endothelial cells and is synthesized via recombinant DNA technology in Chinese hamster ovary cells0.90text
Alteplaseis astandard of care0.90text
Alteplaseis amost commonly used medication to treat pulmonary embolism0.90text
Alteplaseis athrombolytic medication0.90text

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