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ABCG2: Function, Inhibition & Overview

ATP-binding cassette subfamily G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338 (cluster of differentiation w338). ABCG2 is a translocation protein used to actively pump drugs and other compounds against their concentration gradient using the bonding and hydrolysis of ATP as the energy source.

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ABCG2 topic overview

The analysis highlights Function, Inhibition and Overview as prominent areas in the source structure around ABCG2.

Related topics: 27
Source areas: 3
Connected nodes: 30
Extracted relationships: 138
Concept neighborhoods: 12
Bridge connections: 30

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 14 topics

Overview · 8 topics

Inhibition · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

7.6.2.2: ↗
Aliases: ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, MXR-1,…
Band: 4q22.1 · 6 B3|6 27.82 cM
Bgee: jejunal mucosa · mucosa of ileum · endothelial cell · mucosa of transverse colon · seminal vesicula
BioGPS: More reference expression data
Chr.: Chromosome 4 (human) · Chromosome 6 (mouse)

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Function

Antigen Apical membrane ATP-binding cassette (ABC) transporters Biotin Blood–brain barrier

Inhibition

Amlodipine Felodipine Fumitremorgin C Nifedipine Tetracyclic

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
Cluster of differentiation
ATP Adenosine triphosphate
Homodimer Protein dimer
KDa Dalton (unit)
Substrate Substrate (chemistry)
Polycyclic chemicals Polycyclic compound

Function

ATP-binding cassette (ABC) transporters ATP-binding cassette transporter
N-terminus
Xenobiotics Xenobiotic
Placenta
Apical membrane
Blood–testis barrier
Blood–brain barrier
Hematopoietic progenitor Hematopoietic stem cell
Stem cells Stem cell
Riboflavin
Biotin
Urate
Antigen
Junior blood group system

Inhibition

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ABCG2 connects Entity context

The extracted context around ABCG2 shows recurring relationship patterns in the source. For example, ABCG2 → ABC-type xenobiotic transporter activity, apical plasma membrane, ATP binding, ATPase activity, ATPase-coupled transmembrane transporter activity, cellular detoxification, cellular iron ion homeostasis, cholesterol efflux, cholesterol transfer activity, heme transmembrane transporter activity, heme transport, identical protein binding, integral component of membrane, membrane, mitochondrial membranes, mitochondrion, nucleotide binding, nucleus, plasma membrane, protein binding Another extracted example is ABCG2 → ABC, ABC1, ABCG2-mediated, Additionally, ALD, Alternatively, ATP, ATP-binding, BCRP, Early, GCN20, MDR/TAP, MRP, N-terminus, NBD, NBDs, OABP, Significant, The, The NBD. Use these groups to spot repeated connection types before inspecting the individual relationships.

ABCG2

Top relations

Gene ontology · 28

ABCG2 → ABC-type xenobiotic transporter activity, apical plasma membrane, ATP binding, ATPase activity, ATPase-coupled transmembrane transporter activity, cellular detoxification, cellular iron ion homeostasis, cholesterol efflux, cholesterol transfer activity, heme transmembrane transporter activity, heme transport, identical protein binding, integral component of membrane, membrane, mitochondrial membranes, mitochondrion, nucleotide binding, nucleus, plasma membrane, protein binding

related to Function · 23

ABCG2 → ABC, ABC1, ABCG2-mediated, Additionally, ALD, Alternatively, ATP, ATP-binding, BCRP, Early, GCN20, MDR/TAP, MRP, N-terminus, NBD, NBDs, OABP, Significant, The, The NBD

Bgee · 20

ABCG2 → C1 segment, duodenum, endothelial cell, fetal liver hematopoietic progenitor cell, human fetus, human kidney, ileum, internal globus pallidus, jejunal mucosa, jejunum, mucosa of ileum, mucosa of transverse colon, placenta, proximal tubule, right kidney, sciatic nerve, seminal vesicula, substantia nigra, tail of embryo, yolk sac

RNA expression pattern · 20

related to External links · 15

ABCG2 → ATP-binding, Broad, Human ABCG2, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Overview, PDB, PDBe-KB, Q9UNQ0, This, UCSC Genome Browser, UniProt, United States National Library

related to Inhibition · 4

ABCG2 → FTC, It, Ko-143, The

Band · 2

ABCG2 → 4q22.1, 6 B3|6 27.82 cM

Chr. · 2

ABCG2 → Chromosome 4 (human), Chromosome 6 (mouse)

End · 2

ABCG2 → 58,672,661 bp, 88,231,628 bp

7.6.2.2 · 1

ABCG2 → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein human bp gene transport chr atp band binding transporter atp-binding cassette chromosome compounds also location membranes subfamily member expression

ABCG2 relationships Subject–Predicate–Object triples

TTTA extracted 138 structured relationships around ABCG2. Examples in this analysis include ABCG2 → 7.6.2.2 → ↗ and ABCG2 → Aliases → ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, MXR-1,…. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
ABCG2	7.6.2.2	↗	1.00	infobox
ABCG2	Aliases	ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, MXR-1,…	1.00	infobox
ABCG2	Band	4q22.1	1.00	infobox
ABCG2	Band	6 B3\|6 27.82 cM	1.00	infobox
ABCG2	Bgee	jejunal mucosa	1.00	infobox
ABCG2	Bgee	mucosa of ileum	1.00	infobox
ABCG2	Bgee	endothelial cell	1.00	infobox
ABCG2	Bgee	mucosa of transverse colon	1.00	infobox
ABCG2	Bgee	seminal vesicula	1.00	infobox
ABCG2	Bgee	duodenum	1.00	infobox
ABCG2	Bgee	substantia nigra	1.00	infobox
ABCG2	Bgee	internal globus pallidus	1.00	infobox
ABCG2	Bgee	placenta	1.00	infobox
ABCG2	Bgee	C1 segment	1.00	infobox
ABCG2	Bgee	right kidney	1.00	infobox
ABCG2	Bgee	proximal tubule	1.00	infobox
ABCG2	Bgee	human kidney	1.00	infobox
ABCG2	Bgee	ileum	1.00	infobox
ABCG2	Bgee	fetal liver hematopoietic progenitor cell	1.00	infobox
ABCG2	Bgee	yolk sac	1.00	infobox
ABCG2	Bgee	jejunum	1.00	infobox
ABCG2	Bgee	tail of embryo	1.00	infobox
ABCG2	Bgee	sciatic nerve	1.00	infobox
ABCG2	Bgee	human fetus	1.00	infobox
ABCG2	BioGPS	More reference expression data	1.00	infobox
ABCG2	Chr.	Chromosome 4 (human)	1.00	infobox
ABCG2	Chr.	Chromosome 6 (mouse)	1.00	infobox
ABCG2	Databases	NCBI: entry; OMA: entry	1.00	infobox
ABCG2	End	88,231,628 bp	1.00	infobox
ABCG2	End	58,672,661 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ABCG2 bring nearby vocabulary together. In this analysis, examples include Atp-binding, Cassette and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

ABCG2
- Atp-binding
- Cassette
- Gene
- Human
- Location
- Atp
- Binding
- Protein
- Transporter
- Cdw338
- Encoded
- Q9unq0
abcg2
- Atp-binding
- Cassette
- Gene
- Human
- Location
- Atp
- Binding
- Protein
- Transporter
- Cdw338
- Encoded
- Q9unq0
protein
- Transporter
- Expression
- Transport
- Encoded
- Energy
- Conserved
- Function
- Subfamily
- Xenobiotic
- Also
- Role
- Atp
gene
- Location
- Human
- Chromosome
- Bp
- Chr
- Mouse
- Function
- Member
- Subfamily
- Band
- Atp
- Binding
atp
- Binding
- Function
- Molecules
- Abc
- Chromosome
- Location
- Atp-binding
- Bp
- Cassette
- Chr
- Gene
- Human
atp-binding cassette (abc) transporters
- Cassette
- Gene
- Abcg2
- Encoded
- Molecules
- Q9unq0
- Uniprot
- Human
- Transporter
- Function
- Member
- Membranes
apical membrane
- Membranes
- Kidney
- Transporter
- Encoded
- Mouse
- Q9unq0
- Uniprot
- Blood
- Expression
- Function
- Xenobiotic
- Abc
function
- Chromosome
- Location
- Bp
- Chr
- Gene
- Human
- Transporter
- Cdw338
- Mouse
- Q9unq0
- Uniprot
- Apical

Connections between topic areas Semantic bridges

For ABCG2, one of the stronger structural bridges in this analysis connects ABCG2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

ABCG2 — Function · splits 16 ⟂ 15

ABCG2 — Overview · splits 22 ⟂ 9

ABCG2 — Inhibition · splits 25 ⟂ 6

Map overview Semantic statistics

ABCG2

Nodes31

Edges30

Triples138

Avg. degree1.94

Density0.064516

Components1

Source & methodology

TTTA analyzes the structure around ABCG2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Inhibition & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ABCG2 · EN edition · Analysis: TopicsToTalkAbout

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