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ATP-binding cassette subfamily G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338 (cluster of differentiation w338). ABCG2 is a translocation protein used to actively pump drugs and other compounds against their concentration gradient using the bonding and hydrolysis of ATP as the energy source.
The analysis highlights Function, Inhibition and Overview as prominent areas in the source structure around ABCG2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around ABCG2 shows recurring relationship patterns in the source. For example, ABCG2 → ABC-type xenobiotic transporter activity, apical plasma membrane, ATP binding, ATPase activity, ATPase-coupled transmembrane transporter activity, cellular detoxification, cellular iron ion homeostasis, cholesterol efflux, cholesterol transfer activity, heme transmembrane transporter activity, heme transport, identical protein binding, integral component of membrane, membrane, mitochondrial membranes, mitochondrion, nucleotide binding, nucleus, plasma membrane, protein binding Another extracted example is ABCG2 → C1 segment, duodenum, endothelial cell, fetal liver hematopoietic progenitor cell, human fetus, human kidney, ileum, internal globus pallidus, jejunal mucosa, jejunum, mucosa of ileum, mucosa of transverse colon, placenta, proximal tubule, right kidney, sciatic nerve, seminal vesicula, substantia nigra, tail of embryo, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.
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protein human bp gene transport chr atp band binding transporter atp-binding cassette chromosome compounds also location membranes subfamily member expression
TTTA extracted 118 structured relationships around ABCG2. Examples in this analysis include ABCG2 → 7.6.2.2 → ↗ and ABCG2 → Aliases → ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, MXR-1,…. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| ABCG2 | 7.6.2.2 | ↗ | 1.00 | infobox |
| ABCG2 | Aliases | ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, MXR-1,… | 1.00 | infobox |
| ABCG2 | Band | 4q22.1 | 1.00 | infobox |
| ABCG2 | Band | 6 B3|6 27.82 cM | 1.00 | infobox |
| ABCG2 | Bgee | jejunal mucosa | 1.00 | infobox |
| ABCG2 | Bgee | mucosa of ileum | 1.00 | infobox |
| ABCG2 | Bgee | endothelial cell | 1.00 | infobox |
| ABCG2 | Bgee | mucosa of transverse colon | 1.00 | infobox |
| ABCG2 | Bgee | seminal vesicula | 1.00 | infobox |
| ABCG2 | Bgee | duodenum | 1.00 | infobox |
| ABCG2 | Bgee | substantia nigra | 1.00 | infobox |
| ABCG2 | Bgee | internal globus pallidus | 1.00 | infobox |
| ABCG2 | Bgee | placenta | 1.00 | infobox |
| ABCG2 | Bgee | C1 segment | 1.00 | infobox |
| ABCG2 | Bgee | right kidney | 1.00 | infobox |
| ABCG2 | Bgee | proximal tubule | 1.00 | infobox |
| ABCG2 | Bgee | human kidney | 1.00 | infobox |
| ABCG2 | Bgee | ileum | 1.00 | infobox |
| ABCG2 | Bgee | fetal liver hematopoietic progenitor cell | 1.00 | infobox |
| ABCG2 | Bgee | yolk sac | 1.00 | infobox |
| ABCG2 | Bgee | jejunum | 1.00 | infobox |
| ABCG2 | Bgee | tail of embryo | 1.00 | infobox |
| ABCG2 | Bgee | sciatic nerve | 1.00 | infobox |
| ABCG2 | Bgee | human fetus | 1.00 | infobox |
| ABCG2 | BioGPS | More reference expression data | 1.00 | infobox |
| ABCG2 | Chr. | Chromosome 4 (human) | 1.00 | infobox |
| ABCG2 | Chr. | Chromosome 6 (mouse) | 1.00 | infobox |
| ABCG2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| ABCG2 | End | 88,231,628 bp | 1.00 | infobox |
| ABCG2 | End | 58,672,661 bp | 1.00 | infobox |
The concept neighborhoods around ABCG2 bring nearby vocabulary together. In this analysis, examples include Atp-binding, Cassette and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For ABCG2, one of the stronger structural bridges in this analysis connects ABCG2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around ABCG2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Inhibition & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — ABCG2 · EN edition · Analysis: TopicsToTalkAbout