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ABCG2

ATP-binding cassette subfamily G member 2 is a protein that in humans is encoded by the ABCG2 gene. ABCG2 has also been designated as CDw338 (cluster of differentiation w338). ABCG2 is a translocation protein used to actively pump drugs and other compounds against their concentration gradient using the bonding and hydrolysis of ATP as the energy source.

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7.6.2.2
↗
Aliases
ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, MXR-1,…
Band
4q22.1 · 6 B3|6 27.82 cM
Bgee
jejunal mucosa · mucosa of ileum · endothelial cell · mucosa of transverse colon · seminal vesicula
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 6 (mouse)

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Function

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ABCG2

Nodes31
Edges30
Triples138
Avg. degree1.94
Density0.064516
Components1

How this topic connects Entity context

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ABCG2

Top relations

Gene ontology · 28
ABCG2 → ABC-type xenobiotic transporter activity, apical plasma membrane, ATP binding, ATPase activity, ATPase-coupled transmembrane transporter activity, cellular detoxification, cellular iron ion homeostasis, cholesterol efflux, cholesterol transfer activity, heme transmembrane transporter activity, heme transport, identical protein binding, integral component of membrane, membrane, mitochondrial membranes, mitochondrion, nucleotide binding, nucleus, plasma membrane, protein binding
related to Function · 23
ABCG2 → ABC, ABC1, ABCG2-mediated, Additionally, ALD, Alternatively, ATP, ATP-binding, BCRP, Early, GCN20, MDR/TAP, MRP, N-terminus, NBD, NBDs, OABP, Significant, The, The NBD
Bgee · 20
ABCG2 → C1 segment, duodenum, endothelial cell, fetal liver hematopoietic progenitor cell, human fetus, human kidney, ileum, internal globus pallidus, jejunal mucosa, jejunum, mucosa of ileum, mucosa of transverse colon, placenta, proximal tubule, right kidney, sciatic nerve, seminal vesicula, substantia nigra, tail of embryo, yolk sac
RNA expression pattern · 20
ABCG2 → C1 segment, duodenum, endothelial cell, fetal liver hematopoietic progenitor cell, human fetus, human kidney, ileum, internal globus pallidus, jejunal mucosa, jejunum, mucosa of ileum, mucosa of transverse colon, placenta, proximal tubule, right kidney, sciatic nerve, seminal vesicula, substantia nigra, tail of embryo, yolk sac
related to External links · 15
ABCG2 → ATP-binding, Broad, Human ABCG2, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Overview, PDB, PDBe-KB, Q9UNQ0, This, UCSC Genome Browser, UniProt, United States National Library
related to Inhibition · 4
ABCG2 → FTC, It, Ko-143, The
Band · 2
ABCG2 → 4q22.1, 6 B3|6 27.82 cM
Chr. · 2
ABCG2 → Chromosome 4 (human), Chromosome 6 (mouse)
End · 2
ABCG2 → 58,672,661 bp, 88,231,628 bp
7.6.2.2 · 1
ABCG2 → ↗

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Important terminology

protein human bp gene transport chr atp band binding transporter atp-binding cassette chromosome compounds also location membranes subfamily member expression

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ABCG27.6.2.2↗1.00infobox
ABCG2AliasesABCG2, ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group), ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, MXR-1,…1.00infobox
ABCG2Band4q22.11.00infobox
ABCG2Band6 B3|6 27.82 cM1.00infobox
ABCG2Bgeejejunal mucosa1.00infobox
ABCG2Bgeemucosa of ileum1.00infobox
ABCG2Bgeeendothelial cell1.00infobox
ABCG2Bgeemucosa of transverse colon1.00infobox
ABCG2Bgeeseminal vesicula1.00infobox
ABCG2Bgeeduodenum1.00infobox
ABCG2Bgeesubstantia nigra1.00infobox
ABCG2Bgeeinternal globus pallidus1.00infobox
ABCG2Bgeeplacenta1.00infobox
ABCG2BgeeC1 segment1.00infobox
ABCG2Bgeeright kidney1.00infobox
ABCG2Bgeeproximal tubule1.00infobox
ABCG2Bgeehuman kidney1.00infobox
ABCG2Bgeeileum1.00infobox
ABCG2Bgeefetal liver hematopoietic progenitor cell1.00infobox
ABCG2Bgeeyolk sac1.00infobox
ABCG2Bgeejejunum1.00infobox
ABCG2Bgeetail of embryo1.00infobox
ABCG2Bgeesciatic nerve1.00infobox
ABCG2Bgeehuman fetus1.00infobox
ABCG2BioGPSMore reference expression data1.00infobox
ABCG2Chr.Chromosome 4 (human)1.00infobox
ABCG2Chr.Chromosome 6 (mouse)1.00infobox
ABCG2DatabasesNCBI: entry; OMA: entry1.00infobox
ABCG2End88,231,628 bp1.00infobox
ABCG2End58,672,661 bp1.00infobox

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