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Lck

Lck (neboli lymphocyte-specific tyrosine kinase, dříve známá jako p56lck) je protein-tyrosin kináza ze skupiny SRC kináz, která hraje významnou roli v aktivaci T lymfocytů. LCK se nachází v cytoplazmě lymfocytů, kde asociuje s cytoplazmatickými konci ko-receptorů CD4 a CD8. Po navázání antigenu na T buněčný receptor (TCR), LCK fosforyluje cytoplasmatické…

Struktura, Signalizace & Regulace

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Struktura

6 related topics

Signalizace

4 related topics

Regulace

3 related topics

Overview

8 related topics

Topics to explore

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Overview

Struktura

Signalizace

  • MHC Hlavní histokompatibilní komplex
  • ITAM
  • CD3 CD3?action=edit&redlink=1
  • ZAP-70 ZAP-70?action=edit&redlink=1

Regulace

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Map overview Semantic statistics

Lck

Nodes26
Edges25
Triples32
Avg. degree1.92
Density0.076923
Components1

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Lck

Top relations

related to Signalizace · 11
Lck → Aktivovaná ZAP-70, CD3, CD4, CD8, Immunoreceptor Tyrosine-based Activation Motif, ITAM, MHC, Na, Po, TCR, ZAP-70
related to Struktura · 11
Lck → Blíže, CD4, CD8, Další, N-terminálním, Na C-konci LCK, Na N-terminální, Na SH1, SH1, SH2, SH3
related to Regulace · 8
Lck → CD45, CSK, Jelikož LCK, Opačnou, Při, SH2, TCR, Ztráta CD45
related to Externí odkazy · 2
Lck → Obrázky, Wikimedia Commons

Important terminology Word statistics

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Important terminology

kinázy tcr aktivaci antigenu fosforyluje cd4 cd8 zap-70 kináza dochází nachází lymfocytů tyrosinový csk cd45 domény sh2 aktivní zbytek vede

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Lckrelated to Externí odkazyObrázky0.60section
Lckrelated to Externí odkazyWikimedia Commons0.60section
Lckrelated to RegulaceJelikož LCK0.60section
Lckrelated to RegulaceTCR0.60section
Lckrelated to RegulaceCSK0.60section
Lckrelated to RegulaceSH20.60section
Lckrelated to RegulacePři0.60section
Lckrelated to RegulaceOpačnou0.60section
Lckrelated to RegulaceCD450.60section
Lckrelated to RegulaceZtráta CD450.60section
Lckrelated to SignalizaceCD40.60section
Lckrelated to SignalizaceCD80.60section

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    Min side: 3
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