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Lck (neboli lymphocyte-specific tyrosine kinase, dříve známá jako p56lck) je protein-tyrosin kináza ze skupiny SRC kináz, která hraje významnou roli v aktivaci T lymfocytů. LCK se nachází v cytoplazmě lymfocytů, kde asociuje s cytoplazmatickými konci ko-receptorů CD4 a CD8. Po navázání antigenu na T buněčný receptor (TCR), LCK fosforyluje cytoplasmatické…
Struktura, Signalizace & Regulace
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kinázy tcr aktivaci antigenu fosforyluje cd4 cd8 zap-70 kináza dochází nachází lymfocytů tyrosinový csk cd45 domény sh2 aktivní zbytek vede
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Lck | related to Externí odkazy | Obrázky | 0.60 | section |
| Lck | related to Externí odkazy | Wikimedia Commons | 0.60 | section |
| Lck | related to Regulace | Jelikož LCK | 0.60 | section |
| Lck | related to Regulace | TCR | 0.60 | section |
| Lck | related to Regulace | CSK | 0.60 | section |
| Lck | related to Regulace | SH2 | 0.60 | section |
| Lck | related to Regulace | Při | 0.60 | section |
| Lck | related to Regulace | Opačnou | 0.60 | section |
| Lck | related to Regulace | CD45 | 0.60 | section |
| Lck | related to Regulace | Ztráta CD45 | 0.60 | section |
| Lck | related to Signalizace | CD4 | 0.60 | section |
| Lck | related to Signalizace | CD8 | 0.60 | section |
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